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TRHDE thyrotropin releasing hormone degrading enzyme [ Homo sapiens (human) ]

Gene ID: 29953, updated on 22-May-2020

Summary

Official Symbol
TRHDEprovided by HGNC
Official Full Name
thyrotropin releasing hormone degrading enzymeprovided by HGNC
Primary source
HGNC:HGNC:30748
See related
Ensembl:ENSG00000072657 MIM:606950
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAP-II; PGPEP2; TRH-DE
Summary
This gene encodes a member of the peptidase M1 family. The encoded protein is an extracellular peptidase that specifically cleaves and inactivates the neuropeptide thyrotropin-releasing hormone.[provided by RefSeq, Dec 2008]
Expression
Broad expression in brain (RPKM 3.0), fat (RPKM 2.9) and 17 other tissues See more
Orthologs

Genomic context

See TRHDE in Genome Data Viewer
Location:
12q21.1
Exon count:
24
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (72087288..72666662)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (72666314..73059422)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene TBC1 domain family member 15 Neighboring gene MRS2 pseudogene 2 Neighboring gene Sharpr-MPRA regulatory region 15256 Neighboring gene tryptophan hydroxylase 2 Neighboring gene TRHDE antisense RNA 1 Neighboring gene H3 histone pseudogene 35 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 3 pseudogene 2 Neighboring gene uncharacterized LOC105369838 Neighboring gene long intergenic non-protein coding RNA 2444

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Chemerin, a novel adipokine in the regulation of angiogenesis.
NHGRI GWA Catalog
Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study.
NHGRI GWA Catalog
Genome-wide association study of rheumatoid arthritis in Koreans: population-specific loci as well as overlap with European susceptibility loci.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ22381

Gene Ontology Provided by GOA

Function Evidence Code Pubs
aminopeptidase activity TAS
Traceable Author Statement
more info
PubMed 
metalloaminopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
peptide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular exosome HDA PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
thyrotropin-releasing hormone-degrading ectoenzyme
Names
TRH-degrading ectoenzyme
TRH-specific aminopeptidase
pyroglutamyl aminopeptidase II
pyroglutamyl-peptidase II
thyroliberinase
XP_005268876.2
XP_011536550.1
XP_016874732.2
XP_016874733.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046971.1 RefSeqGene

    Range
    5170..398063
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_013381.3NP_037513.2  thyrotropin-releasing hormone-degrading ectoenzyme

    Status: REVIEWED

    Source sequence(s)
    AC016256, AC078921, AC087886, AC133480
    Consensus CDS
    CCDS9004.1
    Related
    ENSP00000261180.4, ENST00000261180.9

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    72087288..72666662
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017019244.1XP_016874733.1  thyrotropin-releasing hormone-degrading ectoenzyme isoform X3

  2. XM_017019243.2XP_016874732.2  thyrotropin-releasing hormone-degrading ectoenzyme isoform X1

    Conserved Domains (2) summary
    cd09601
    Location:148598
    M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
    pfam11838
    Location:678947
    ERAP1_C; ERAP1-like C-terminal domain
  3. XM_005268819.5XP_005268876.2  thyrotropin-releasing hormone-degrading ectoenzyme isoform X2

    Conserved Domains (2) summary
    cd09601
    Location:148598
    M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
    pfam11838
    Location:678729
    ERAP1_C; ERAP1-like C-terminal domain
  4. XM_011538248.2XP_011536550.1  thyrotropin-releasing hormone-degrading ectoenzyme isoform X4

    Conserved Domains (2) summary
    pfam11838
    Location:274593
    ERAP1_C; ERAP1-like C-terminal domain
    cl14813
    Location:1193
    GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)
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