OSGIN1 oxidative stress induced growth inhibitor 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: OSGIN1provided by HGNC
Official Full Name: oxidative stress induced growth inhibitor 1provided by HGNC
Primary source: HGNC:HGNC:30093
See related: Ensembl:ENSG00000140961 MIM:607975; AllianceGenome:HGNC:30093
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: BDGI; OKL38
Summary: This gene encodes an oxidative stress response protein that regulates cell death. Expression of the gene is regulated by p53 and is induced by DNA damage. The protein regulates apoptosis by inducing cytochrome c release from mitochondria. It also appears to be a key regulator of both inflammatory and anti-inflammatory molecules. The loss of this protein correlates with uncontrolled cell growth and tumor formation. Naturally occurring read-through transcription exists between this gene and the neighboring upstream malonyl-CoA decarboxylase (MLYCD) gene, but the read-through transcripts are unlikely to produce a protein product. [provided by RefSeq, Aug 2011]
Expression: Broad expression in liver (RPKM 32.8), duodenum (RPKM 12.4) and 14 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 16q23.3

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2023_03	current	GRCh38.p14 (GCF_000001405.40)	16	NC_000016.10 (83953240..83966332)
RS_2023_03	current	T2T-CHM13v2.0 (GCF_009914755.1)	16	NC_060940.1 (90019300..90032388)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	16	NC_000016.9 (83986845..83999937)

Chromosome 16 - NC_000016.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A novel biochemical marker -OKL38- with its apoptotic and antioxidant properties for the development of PCOS and its related clinical implications.
Title: A novel biochemical marker -OKL38- with its apoptotic and antioxidant properties for the development of PCOS and its related clinical implications.
Bone marrow stromal cell-derived growth inhibitor serves as a stress sensor to induce autophagy.
Title: Bone marrow stromal cell-derived growth inhibitor serves as a stress sensor to induce autophagy.
using purified OSGEPL1, we identified multiple acetylation sites, and OSGEPL1 activity was readily affected by acetylation via multiple mechanisms in vitro and in vivo.
Title: Molecular basis for t6A modification in human mitochondria.
The results support the concept that smoking-induced upregulation of OSGIN1 is one link between smoking-induced stress and enhanced-autophagy in the human airway epithelium.
Title: Role of OSGIN1 in mediating smoking-induced autophagy in the human airway epithelium.
miR-320a has a role in modulating the induction of HO-1, GCLM and OKL38 by oxidized phospholipids in endothelial cells
Title: MicroRNA miR-320a modulates induction of HO-1, GCLM and OKL38 by oxidized phospholipids in endothelial cells.
Identify OSGIN1 as a tumor suppressor that is down-regulated or altered in human hepatocellular carcinoma.
Title: Allele-specific imbalance of oxidative stress-induced growth inhibitor 1 associates with progression of hepatocellular carcinoma.
Data suggest that OKL38 regulates mitochondria morphology and functions during apoptosis together with p53.
Title: Interaction of OKL38 and p53 in regulating mitochondrial structure and function.
Observational study of gene-disease association. (HuGE Navigator)
Title: Association of genetic variants with hemorrhagic stroke in Japanese individuals.
identify OKL38 as a novel p53 target gene that is regulated by Peptidylarginine deiminase 4 and plays a role in apoptosis
Title: Histone Arg modifications and p53 regulate the expression of OKL38, a mediator of apoptosis.
The 5'UTRs of OKL38 might play an important role in downregulation of its protein and the absence of OKL38 could lead to the development or progression of hepatocellular carcinoma.
Title: The role of 5' untranslated region in translational suppression of OKL38 mRNA in hepatocellular carcinoma.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

WI-15020 (e-PCR)
- UniSTS:74303

NoName (e-PCR)
- UniSTS:483211

SHGC-147839 (e-PCR)
- UniSTS:182967

Homology

Homologs of the OSGIN1 gene: The OSGIN1 gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, mosquito, and frog.
Orthologs from Annotation Pipeline: 330 organisms have orthologs with human gene OSGIN1
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables growth factor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables growth factor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell growth	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in negative regulation of cell growth	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info
involved_in regulation of cell migration	IMP Inferred from Mutant Phenotype more info
involved_in regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: oxidative stress-induced growth inhibitor 1

Names: BMSC-derived growth inhibitor; bone marrow stromal cell-derived growth inhibitor; ovary, kidney and liver protein 38; pregnancy-induced growth inhibitor OKL38

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029757.1 RefSeqGene

Range

5019..18111

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mRNA and Protein(s)

NM_182981.3 → NP_892026.1 oxidative stress-induced growth inhibitor 1

See identical proteins and their annotated locations for NP_892026.1

Status: REVIEWED

Source sequence(s)

AC040169, AY258068, BM976366

Consensus CDS

CCDS10939.1

UniProtKB/Swiss-Prot

Q9BZ70, Q9UJX0

Related

ENSP00000376983.1, ENST00000393306.6

Conserved Domains (1) summary

TIGR04018
Location:177 → 471

Bthiol_YpdA; putative bacillithiol system oxidoreductase, YpdA family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000016.10 Reference GRCh38.p14 Primary Assembly

Range

83953240..83966332

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Alternate T2T-CHM13v2.0

Genomic

NC_060940.1 Alternate T2T-CHM13v2.0

Range

90019300..90032388

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GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_013370.3: Suppressed sequence

Description

NM_013370.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein, and the transcript appears to retain an intron at its 5' end.
NM_182980.2: Suppressed sequence

Description

NM_182980.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript, which appears to retain an intron at its 5' end.