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OSGIN1 oxidative stress induced growth inhibitor 1 [ Homo sapiens (human) ]

Gene ID: 29948, updated on 7-Jun-2020

Summary

Official Symbol
OSGIN1provided by HGNC
Official Full Name
oxidative stress induced growth inhibitor 1provided by HGNC
Primary source
HGNC:HGNC:30093
See related
Ensembl:ENSG00000140961 MIM:607975
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BDGI; OKL38
Summary
This gene encodes an oxidative stress response protein that regulates cell death. Expression of the gene is regulated by p53 and is induced by DNA damage. The protein regulates apoptosis by inducing cytochrome c release from mitochondria. It also appears to be a key regulator of both inflammatory and anti-inflammatory molecules. The loss of this protein correlates with uncontrolled cell growth and tumor formation. Naturally occurring read-through transcription exists between this gene and the neighboring upstream malonyl-CoA decarboxylase (MLYCD) gene, but the read-through transcripts are unlikely to produce a protein product. [provided by RefSeq, Aug 2011]
Expression
Broad expression in liver (RPKM 32.8), duodenum (RPKM 12.4) and 14 other tissues See more
Orthologs

Genomic context

See OSGIN1 in Genome Data Viewer
Location:
16q23.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (83953240..83966332)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (83982594..83999937)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371372 Neighboring gene uncharacterized LOC105371371 Neighboring gene N-terminal EF-hand calcium binding protein 2 Neighboring gene solute carrier family 38 member 8 Neighboring gene RNA, 5S ribosomal pseudogene 432

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: MLYCD

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
growth factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
growth factor activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell growth IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of cell growth IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 

General protein information

Preferred Names
oxidative stress-induced growth inhibitor 1
Names
BMSC-derived growth inhibitor
bone marrow stromal cell-derived growth inhibitor
ovary, kidney and liver protein 38
pregnancy-induced growth inhibitor OKL38

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029757.1 RefSeqGene

    Range
    5019..18111
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_182981.3NP_892026.1  oxidative stress-induced growth inhibitor 1

    See identical proteins and their annotated locations for NP_892026.1

    Status: REVIEWED

    Source sequence(s)
    AC040169, AY258068, BM976366
    Consensus CDS
    CCDS10939.1
    UniProtKB/Swiss-Prot
    Q9UJX0
    Related
    ENSP00000376983.1, ENST00000393306.6
    Conserved Domains (1) summary
    cl26177
    Location:177471
    Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    83953240..83966332
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_013370.3: Suppressed sequence

    Description
    NM_013370.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein, and the transcript appears to retain an intron at its 5' end.
  2. NM_182980.2: Suppressed sequence

    Description
    NM_182980.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript, which appears to retain an intron at its 5' end.
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