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SERTAD3 SERTA domain containing 3 [ Homo sapiens (human) ]

Gene ID: 29946, updated on 7-Jun-2020

Summary

Official Symbol
SERTAD3provided by HGNC
Official Full Name
SERTA domain containing 3provided by HGNC
Primary source
HGNC:HGNC:17931
See related
Ensembl:ENSG00000167565 MIM:612125
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RBT1
Summary
The protein encoded by this gene was identified in a yeast two-hybrid assay employing the second subunit of human replication protein A as bait. It is localized to the nucleus and its expression is significantly higher in cancer cell lines compared to normal cell lines. This protein has also been shown to be a strong transcriptional co-activator. Alternative splicing has been observed at this locus and two variants, both encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in placenta (RPKM 11.9), prostate (RPKM 10.6) and 25 other tissues See more
Orthologs

Genomic context

See SERTAD3 in Genome Data Viewer
Location:
19q13.2
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (40440841..40444335, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (40946748..40950282, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene SERTA domain containing 1 Neighboring gene CRISPRi-validated cis-regulatory element chr19.4185 Neighboring gene uncharacterized LOC105372489 Neighboring gene biliverdin reductase B Neighboring gene spectrin beta, non-erythrocytic 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
negative regulation of cell growth IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
SERTA domain-containing protein 3
Names
RPA-binding trans-activator
replication protein-binding trans-activator

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013368.3NP_037500.2  SERTA domain-containing protein 3

    See identical proteins and their annotated locations for NP_037500.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AC010271, AF192529, AW242302, BC014061
    Consensus CDS
    CCDS12558.1
    UniProtKB/Swiss-Prot
    Q9UJW9
    UniProtKB/TrEMBL
    A0A024R0N2
    Related
    ENSP00000375882.3, ENST00000392028.8
    Conserved Domains (1) summary
    pfam06031
    Location:3366
    SERTA; SERTA motif
  2. NM_203344.3NP_976219.1  SERTA domain-containing protein 3

    See identical proteins and their annotated locations for NP_976219.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AW242302, BC050643
    Consensus CDS
    CCDS12558.1
    UniProtKB/Swiss-Prot
    Q9UJW9
    UniProtKB/TrEMBL
    A0A024R0N2
    Related
    ENSP00000325414.2, ENST00000322354.4
    Conserved Domains (1) summary
    pfam06031
    Location:3366
    SERTA; SERTA motif

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    40440841..40444335 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005258832.4XP_005258889.1  SERTA domain-containing protein 3 isoform X1

    See identical proteins and their annotated locations for XP_005258889.1

    UniProtKB/Swiss-Prot
    Q9UJW9
    UniProtKB/TrEMBL
    A0A024R0N2
    Conserved Domains (1) summary
    pfam06031
    Location:3366
    SERTA; SERTA motif
  2. XM_006723179.3XP_006723242.1  SERTA domain-containing protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006723242.1

    UniProtKB/Swiss-Prot
    Q9UJW9
    UniProtKB/TrEMBL
    A0A024R0N2
    Related
    ENSP00000469245.1, ENST00000599706.1
    Conserved Domains (1) summary
    pfam06031
    Location:3366
    SERTA; SERTA motif
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