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PURG purine rich element binding protein G [ Homo sapiens (human) ]

Gene ID: 29942, updated on 24-Nov-2020

Summary

Official Symbol
PURGprovided by HGNC
Official Full Name
purine rich element binding protein Gprovided by HGNC
Primary source
HGNC:HGNC:17930
See related
Ensembl:ENSG00000172733 MIM:618041
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PURGA; PURGB; PURG-A; PURG-B
Summary
The exact function of this gene is not known, however, its encoded product is highly similar to purine-rich element binding protein A. The latter is a DNA-binding protein which binds preferentially to the single strand of the purine-rich element termed PUR, and has been implicated in the control of both DNA replication and transcription. This gene lies in close proximity to the Werner syndrome gene, but on the opposite strand, on chromosome 8p11. [provided by RefSeq, Apr 2016]
Expression
Biased expression in brain (RPKM 1.4), testis (RPKM 1.1) and 12 other tissues See more
Orthologs

Genomic context

See PURG in Genome Data Viewer
Location:
8p12
Exon count:
3
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (30995802..31033356, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (30853320..30891231, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene testis expressed 15, meiosis and synapsis associated Neighboring gene CRISPRi-validated cis-regulatory element chr8.1136 Neighboring gene lysophosphatidylglycerol acyltransferase 1 pseudogene 1 Neighboring gene WRN RecQ like helicase Neighboring gene SUMO2 pseudogene 16 Neighboring gene uncharacterized LOC105379358

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif modulates the expression of purine-rich element binding protein G (PURG) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC119274

Gene Ontology Provided by GOA

Process Evidence Code Pubs
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
purine-rich element-binding protein gamma
Names
Pur-gamma

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001015508.3NP_001015508.1  purine-rich element-binding protein gamma isoform B

    See identical proteins and their annotated locations for NP_001015508.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (B) differs in the 3' UTR and coding region compared to variant A. The resulting isoform (B) is shorter and has a distinct C-terminus compared to isoform A. Variants B and D encode the same isoform (B).
    Source sequence(s)
    AC008066, AW170055, AY077841
    Consensus CDS
    CCDS34878.1
    UniProtKB/Swiss-Prot
    Q9UJV8
    Related
    ENSP00000345168.2, ENST00000339382.3
    Conserved Domains (1) summary
    pfam04845
    Location:57290
    PurA; PurA ssDNA and RNA-binding protein
  2. NM_001323311.2NP_001310240.1  purine-rich element-binding protein gamma isoform A

    Status: REVIEWED

    Description
    Transcript Variant: This variant (C) differs in the 5' UTR compared to variant A. Variants A and C encode the same isoform (A).
    Source sequence(s)
    AC084736, AF195513, DR003356
    Consensus CDS
    CCDS6081.1
    UniProtKB/Swiss-Prot
    Q9UJV8
    Conserved Domains (1) summary
    pfam04845
    Location:57321
    PurA; PurA ssDNA and RNA-binding protein
  3. NM_001323312.2NP_001310241.1  purine-rich element-binding protein gamma isoform B

    Status: REVIEWED

    Description
    Transcript Variant: This variant (D) differs in the 5' and 3' UTR and coding region compared to variant A. The resulting isoform (B) is shorter and has a distinct C-terminus compared to isoform A. Variants B and D encode the same isoform (B).
    Source sequence(s)
    AC008066, AC084736, AW170055, AY077841, DR003356
    Consensus CDS
    CCDS34878.1
    UniProtKB/Swiss-Prot
    Q9UJV8
    Conserved Domains (1) summary
    pfam04845
    Location:57290
    PurA; PurA ssDNA and RNA-binding protein
  4. NM_013357.2NP_037489.1  purine-rich element-binding protein gamma isoform A

    See identical proteins and their annotated locations for NP_037489.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (A) encodes the longer isoform (A). Variants A and C encode the same isoform (A).
    Source sequence(s)
    AF195513
    Consensus CDS
    CCDS6081.1
    UniProtKB/Swiss-Prot
    Q9UJV8
    Related
    ENSP00000418721.1, ENST00000475541.1
    Conserved Domains (1) summary
    pfam04845
    Location:57321
    PurA; PurA ssDNA and RNA-binding protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    30995802..31033356 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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