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RPA4 replication protein A4 [ Homo sapiens (human) ]

Gene ID: 29935, updated on 5-Jan-2022

Summary

Official Symbol
RPA4provided by HGNC
Official Full Name
replication protein A4provided by HGNC
Primary source
HGNC:HGNC:30305
See related
Ensembl:ENSG00000204086 MIM:300767
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSU24186
Summary
This gene encodes a single-stranded DNA-binding protein that is the 30-kDa subunit of the replication protein A complex. Replication protein A is an essential factor for DNA double-strand break repair and cell cycle checkpoint activation. The encoded protein localizes to DNA repair foci and may be involved in the cellular DNA damage response. This protein may also play a role in inhibiting viral replication.[provided by RefSeq, Apr 2010]
Orthologs
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Genomic context

See RPA4 in Genome Data Viewer
Location:
Xq21.33
Exon count:
1
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (96883908..96885467)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (96138907..96140466)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985714 Neighboring gene uncharacterized LOC105373296 Neighboring gene SKP2 pseudogene 1 Neighboring gene diaphanous related formin 2 Neighboring gene NADH:ubiquinone oxidoreductase subunit B5 pseudogene 2 Neighboring gene RNA, 7SL, cytoplasmic 74, pseudogene

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
reverse transcriptase gag-pol Replication protein A and HIV-1 nucleocapsid protein interfere with the strand displacement DNA synthesis of HIV-1 reverse transcriptase by binding to the displaced strand and keeping it away from the newly synthesized strand PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: DIAPH2

Homology

Clone Names

  • MGC120333, MGC120334

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA damage checkpoint signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in DNA repair IDA
Inferred from Direct Assay
more info
PubMed 
involved_in DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in DNA replication initiation TAS
Traceable Author Statement
more info
PubMed 
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NOT involved_in nuclear DNA replication IDA
Inferred from Direct Assay
more info
PubMed 
involved_in nucleotide-excision repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in nucleotide-excision repair IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of DNA replication factor A complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of DNA replication factor A complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of DNA replication factor A complex IPI
Inferred from Physical Interaction
more info
PubMed 
is_active_in chromosome, telomeric region IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in site of double-strand break IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
replication protein A 30 kDa subunit
Names
RF-A protein 4
RP-A p30
replication factor A protein 4
replication protein A complex 34 kd subunit homolog Rpa4
replication protein A4, 30kDa
replication protein A4, 34kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013259.2 RefSeqGene

    Range
    4896..6455
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_013347.4NP_037479.1  replication protein A 30 kDa subunit

    See identical proteins and their annotated locations for NP_037479.1

    Status: REVIEWED

    Source sequence(s)
    BC069791, U24186, Z86061
    Consensus CDS
    CCDS35345.1
    UniProtKB/Swiss-Prot
    Q13156
    Related
    ENSP00000362131.3, ENST00000373040.4
    Conserved Domains (2) summary
    cd04478
    Location:73166
    RPA2_DBD_D; RPA2_DBD_D: A subfamily of OB folds corresponding to the OB fold of the central ssDNA-binding domain (DBD)-D of human RPA2 (also called RPA32). RPA2 is a subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which appears ...
    cl27871
    Location:32259
    RPA_C; Replication protein A C terminal

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    96883908..96885467
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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