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TIMM22 translocase of inner mitochondrial membrane 22 [ Homo sapiens (human) ]

Gene ID: 29928, updated on 10-Dec-2019

Summary

Official Symbol
TIMM22provided by HGNC
Official Full Name
translocase of inner mitochondrial membrane 22provided by HGNC
Primary source
HGNC:HGNC:17317
See related
Ensembl:ENSG00000177370 MIM:607251
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TEX4; TIM22
Summary
Multipass transmembrane proteins are brought into mitochondria and inserted into the mitochondrial inner membrane by way of the TIM22 complex. This complex has six subunits and is a twin-pore translocase. The protein encoded by this gene is a subunit of TIM22 and represents the voltage-activated and signal-gated channel. [provided by RefSeq, Jul 2016]
Expression
Ubiquitous expression in heart (RPKM 10.4), placenta (RPKM 10.3) and 25 other tissues See more
Orthologs

Genomic context

See TIMM22 in Genome Data Viewer
Location:
17p13.3
Exon count:
4
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (997129..1003671)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (900357..905407)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene glyoxalase domain containing 4 Neighboring gene mitochondrial rRNA methyltransferase 3 Neighboring gene nucleoredoxin Neighboring gene uncharacterized LOC101927727 Neighboring gene uncharacterized LOC112268190 Neighboring gene uncharacterized LOC105371481 Neighboring gene ABR activator of RhoGEF and GTPase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Mitochondrial protein import, organism-specific biosystem (from REACTOME)
    Mitochondrial protein import, organism-specific biosystemA human mitochondrion contains about 1500 proteins, more than 99% of which are encoded in the nucleus, synthesized in the cytosol and imported into the mitochondrion. Proteins are targeted to four lo...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
mitochondrion targeting sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein transmembrane transporter activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
protein import into mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein import into mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
protein import into mitochondrial inner membrane TAS
Traceable Author Statement
more info
PubMed 
protein targeting to mitochondrion TAS
Traceable Author Statement
more info
 
protein transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
TIM22 mitochondrial import inner membrane insertion complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
TIM22 mitochondrial import inner membrane insertion complex IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial inner membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
mitochondrial import inner membrane translocase subunit Tim22
Names
testis-expressed protein 4
testis-expressed sequence 4
translocase of inner mitochondrial membrane 22 homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013337.4NP_037469.2  mitochondrial import inner membrane translocase subunit Tim22

    See identical proteins and their annotated locations for NP_037469.2

    Status: REVIEWED

    Source sequence(s)
    AC015884, AI522232, BC002324
    Consensus CDS
    CCDS32521.1
    UniProtKB/Swiss-Prot
    Q9Y584
    Related
    ENSP00000320236.2, ENST00000327158.5
    Conserved Domains (1) summary
    pfam02466
    Location:68190
    Tim17; Tim17/Tim22/Tim23/Pmp24 family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    997129..1003671
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187613.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    36376..42918
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_2

Genomic

  1. NT_187664.1 Reference GRCh38.p13 ALT_REF_LOCI_2

    Range
    36376..42918
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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