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Asb2 ankyrin repeat and SOCS box-containing 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 299266, updated on 2-Oct-2018

Summary

Official Symbol
Asb2provided by RGD
Official Full Name
ankyrin repeat and SOCS box-containing 2provided by RGD
Primary source
RGD:1306414
See related
Ensembl:ENSRNOG00000051619
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Expression
Biased expression in Muscle (RPKM 766.4), Heart (RPKM 560.6) and 3 other tissues See more
Orthologs

Genomic context

See Asb2 in Genome Data Viewer
Location:
6q32
Exon count:
12
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (127212325..127248451, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 6 NC_005105.3 (136425783..136469502, complement)

Chromosome 6 - NC_005105.4Genomic Context describing neighboring genes Neighboring gene proline rich membrane anchor 1 Neighboring gene similar to RIKEN cDNA A830059I20 Neighboring gene uncharacterized LOC102549032 Neighboring gene OTU deubiquitinase, ubiquitin aldehyde binding 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
contributes_to ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
myoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
skeletal muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
Cul5-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
intracellular IEA
Inferred from Electronic Annotation
more info
 
ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ankyrin repeat and SOCS box protein 2
Names
ASB-2
ankyrin repeat and SOCS box-containing protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001011984.1NP_001011984.1  ankyrin repeat and SOCS box protein 2

    See identical proteins and their annotated locations for NP_001011984.1

    Status: PROVISIONAL

    Source sequence(s)
    BC085882
    UniProtKB/Swiss-Prot
    Q5U2S6
    Related
    ENSRNOP00000071182.1, ENSRNOT00000085517.1
    Conserved Domains (4) summary
    cd00204
    Location:232357
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd03721
    Location:590634
    SOCS_ASB2; SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB2 targets specific proteins to destruction by the proteasome in leukemia cells that have been ...
    pfam12796
    Location:308396
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:237268
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005105.4 Reference Rnor_6.0 Primary Assembly

    Range
    127212325..127248451 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006240464.3XP_006240526.1  ankyrin repeat and SOCS box protein 2 isoform X1

    Conserved Domains (4) summary
    cd00204
    Location:127252
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:203291
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:132163
    ANK; ANK repeat [structural motif]
    cl02533
    Location:485529
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

RNA

  1. XR_593075.1 RNA Sequence

Alternate Rn_Celera

Genomic

  1. AC_000074.1 Alternate Rn_Celera

    Range
    119956026..119991593 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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