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HILPDA hypoxia inducible lipid droplet associated [ Homo sapiens (human) ]

Gene ID: 29923, updated on 1-Jun-2020

Summary

Official Symbol
HILPDAprovided by HGNC
Official Full Name
hypoxia inducible lipid droplet associatedprovided by HGNC
Primary source
HGNC:HGNC:28859
See related
Ensembl:ENSG00000135245 MIM:617905
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HIG2; HIG-2; C7orf68
Expression
Broad expression in esophagus (RPKM 37.4), fat (RPKM 20.9) and 20 other tissues See more
Orthologs

Genomic context

See HILPDA in Genome Data Viewer
Location:
7q32.1
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (128455830..128458418)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (128095884..128098472)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ribosomal protein L37 pseudogene 16 Neighboring gene uncharacterized LOC102724660 Neighboring gene RNA, U7 small nuclear 54 pseudogene Neighboring gene methyltransferase like 2B Neighboring gene uncharacterized LOC101928451 Neighboring gene ribosomal protein S10 pseudogene 15

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the expression of hypoxia inducible lipid droplet-associated protein (HILPDA) in human primary T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21076, MGC138388

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
autocrine signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
autocrine signaling IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
lipid droplet organization TAS
Traceable Author Statement
more info
 
positive regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cytokine production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of lipid storage IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
lipid droplet IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lipid droplet IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
secretory granule IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
hypoxia-inducible lipid droplet-associated protein
Names
hypoxia inducible gene 2
hypoxia-inducible gene 2 protein
hypoxia-inducible protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098786.1NP_001092256.1  hypoxia-inducible lipid droplet-associated protein

    See identical proteins and their annotated locations for NP_001092256.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AF144755, AL691669, BC008573, CD686848, CX784347
    Consensus CDS
    CCDS5802.1
    UniProtKB/Swiss-Prot
    Q9Y5L2
    Related
    ENSP00000388871.2, ENST00000435296.2
    Conserved Domains (1) summary
    pfam15220
    Location:163
    HILPDA; Hypoxia-inducible lipid droplet-associated
  2. NM_013332.4NP_037464.1  hypoxia-inducible lipid droplet-associated protein

    See identical proteins and their annotated locations for NP_037464.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AF144755, BC001863, BC008573, CD686848
    Consensus CDS
    CCDS5802.1
    UniProtKB/Swiss-Prot
    Q9Y5L2
    Related
    ENSP00000257696.4, ENST00000257696.5
    Conserved Domains (1) summary
    pfam15220
    Location:163
    HILPDA; Hypoxia-inducible lipid droplet-associated

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    128455830..128458418
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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