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ST8SIA5 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5 [ Homo sapiens (human) ]

Gene ID: 29906, updated on 22-Sep-2022

Summary

Official Symbol
ST8SIA5provided by HGNC
Official Full Name
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5provided by HGNC
Primary source
HGNC:HGNC:17827
See related
Ensembl:ENSG00000101638 MIM:607162; AllianceGenome:HGNC:17827
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SIAT8E; SIAT8-E; ST8SiaV
Summary
The protein encoded by this gene is a type II membrane protein that may be present in the Golgi apparatus. The encoded protein, which is a member of glycosyltransferase family 29, may be involved in the synthesis of gangliosides GD1c, GT1a, GQ1b, and GT3 from GD1a, GT1b, GM1b, and GD3, respectively. [provided by RefSeq, Jul 2008]
Expression
Biased expression in adrenal (RPKM 3.3), brain (RPKM 3.3) and 3 other tissues See more
Orthologs
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Genomic context

See ST8SIA5 in Genome Data Viewer
Location:
18q21.1
Exon count:
8
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (46667821..46757053, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (46858373..46947691, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (44247784..44337016, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene lipoxygenase homology PLAT domains 1 Neighboring gene uncharacterized LOC105372096 Neighboring gene ribosomal protein S21 pseudogene 6 Neighboring gene ST8SIA5 divergent transcript Neighboring gene protein inhibitor of activated STAT 2 Neighboring gene ubiquitin specific peptidase 4 (proto-oncogene) pseudogene Neighboring gene uncharacterized LOC124904294

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC119670, MGC119671

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity TAS
Traceable Author Statement
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sialyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in N-glycan processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in carbohydrate metabolic process TAS
Traceable Author Statement
more info
PubMed 
involved_in glycosphingolipid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in oligosaccharide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
 
involved_in sialylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in Golgi membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
alpha-2,8-sialyltransferase 8E
Names
ST8 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase 5
sialyltransferase 8E (alpha-2, 8-polysialytransferase)
sialyltransferase St8Sia V
NP_001294915.1
NP_001294916.1
NP_037437.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001307986.2NP_001294915.1  alpha-2,8-sialyltransferase 8E isoform 1

    See identical proteins and their annotated locations for NP_001294915.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC064800, AC090311, AK056270, AK293608, U55966
    Consensus CDS
    CCDS77184.1
    UniProtKB/Swiss-Prot
    O15466
    Related
    ENSP00000445492.1, ENST00000538168.5
    Conserved Domains (1) summary
    pfam00777
    Location:153406
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  2. NM_001307987.2NP_001294916.1  alpha-2,8-sialyltransferase 8E isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons in the 5' coding region compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AC064800, AC090311, AK056270, AK298881, U55966
    Consensus CDS
    CCDS77183.1
    UniProtKB/Swiss-Prot
    O15466
    UniProtKB/TrEMBL
    B7Z5F7, F5H8D1
    Related
    ENSP00000443683.1, ENST00000536490.1
    Conserved Domains (1) summary
    pfam00777
    Location:86339
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  3. NM_013305.6NP_037437.2  alpha-2,8-sialyltransferase 8E isoform 2

    See identical proteins and their annotated locations for NP_037437.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC064800, AC090311, AK056270, U55966
    Consensus CDS
    CCDS11930.1
    UniProtKB/Swiss-Prot
    O15466, Q6IAW7
    Related
    ENSP00000321343.6, ENST00000315087.12
    Conserved Domains (1) summary
    pfam00777
    Location:117370
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    46667821..46757053 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    46858373..46947691 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)