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Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma [ Rattus norvegicus (Norway rat) ]

Gene ID: 298947, updated on 18-Apr-2019

Summary

Official Symbol
Pik3cgprovided by RGD
Official Full Name
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gammaprovided by RGD
Primary source
RGD:1306468
See related
Ensembl:ENSRNOG00000009385
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pi3k
Expression
Biased expression in Thymus (RPKM 145.7), Spleen (RPKM 108.5) and 8 other tissues See more
Orthologs

Genomic context

See Pik3cg in Genome Data Viewer
Location:
6q16
Exon count:
11
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (51465696..51501234, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 6 NC_005105.3 (61106730..61142184, complement)

Chromosome 6 - NC_005105.4Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L18a-like Neighboring gene HMG-box transcription factor 1 Neighboring gene protein kinase cAMP-dependent type II regulatory subunit beta Neighboring gene hypothetical LOC100361355 Neighboring gene coiled-coil domain containing 71-like

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
1-phosphatidylinositol-3-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
1-phosphatidylinositol-3-kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
1-phosphatidylinositol-4-phosphate 3-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ephrin receptor binding IEA
Inferred from Electronic Annotation
more info
 
ephrin receptor binding ISO
Inferred from Sequence Orthology
more info
PubMed 
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
PubMed 
kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
phosphatidylinositol-4,5-bisphosphate 3-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to cAMP IEA
Inferred from Electronic Annotation
more info
 
cellular response to cAMP ISO
Inferred from Sequence Orthology
more info
PubMed 
hepatocyte apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of fibroblast apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of fibroblast apoptotic process ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of triglyceride catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphatidylinositol 3-kinase signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol 3-kinase signaling ISO
Inferred from Sequence Orthology
more info
PubMed 
phosphatidylinositol phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylinositol-3-phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of MAP kinase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of acute inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of catalytic activity ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of cytosolic calcium ion concentration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein kinase B signaling IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
PubMed 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
regulation of calcium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
secretory granule localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
phosphatidylinositol 3-kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol 3-kinase complex IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylinositol 3-kinase complex, class IB IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol 3-kinase complex, class IB ISO
Inferred from Sequence Orthology
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Names
phosphoinositide-3-kinase, catalytic, gamma polypeptide
XP_003750188.1
XP_006240065.1
XP_006240066.1
XP_006240067.1
XP_017458652.1

NCBI Reference Sequences (RefSeq)

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005105.4 Reference Rnor_6.0 Primary Assembly

    Range
    51465696..51501234 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006240005.3XP_006240067.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1

    See identical proteins and their annotated locations for XP_006240067.1

    UniProtKB/TrEMBL
    D3ZFJ0
    Conserved Domains (4) summary
    cd08399
    Location:350527
    C2_PI3K_class_I_gamma; C2 domain present in class I gamma phosphatidylinositol 3-kinases (PI3Ks)
    smart00144
    Location:203312
    PI3K_rbd; PI3-kinase family, Ras-binding domain
    cd00872
    Location:549725
    PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
    cd00894
    Location:7291095
    PI3Kc_IB_gamma; Catalytic domain of Class IB Phosphoinositide 3-kinase gamma
  2. XM_006240003.3XP_006240065.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1

    See identical proteins and their annotated locations for XP_006240065.1

    UniProtKB/TrEMBL
    D3ZFJ0
    Related
    ENSRNOP00000012487.3, ENSRNOT00000012487.5
    Conserved Domains (4) summary
    cd08399
    Location:350527
    C2_PI3K_class_I_gamma; C2 domain present in class I gamma phosphatidylinositol 3-kinases (PI3Ks)
    smart00144
    Location:203312
    PI3K_rbd; PI3-kinase family, Ras-binding domain
    cd00872
    Location:549725
    PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
    cd00894
    Location:7291095
    PI3Kc_IB_gamma; Catalytic domain of Class IB Phosphoinositide 3-kinase gamma
  3. XM_006240004.3XP_006240066.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1

    See identical proteins and their annotated locations for XP_006240066.1

    UniProtKB/TrEMBL
    D3ZFJ0
    Conserved Domains (4) summary
    cd08399
    Location:350527
    C2_PI3K_class_I_gamma; C2 domain present in class I gamma phosphatidylinositol 3-kinases (PI3Ks)
    smart00144
    Location:203312
    PI3K_rbd; PI3-kinase family, Ras-binding domain
    cd00872
    Location:549725
    PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
    cd00894
    Location:7291095
    PI3Kc_IB_gamma; Catalytic domain of Class IB Phosphoinositide 3-kinase gamma
  4. XM_003750140.4XP_003750188.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1

    See identical proteins and their annotated locations for XP_003750188.1

    UniProtKB/TrEMBL
    D3ZFJ0
    Conserved Domains (4) summary
    cd08399
    Location:350527
    C2_PI3K_class_I_gamma; C2 domain present in class I gamma phosphatidylinositol 3-kinases (PI3Ks)
    smart00144
    Location:203312
    PI3K_rbd; PI3-kinase family, Ras-binding domain
    cd00872
    Location:549725
    PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
    cd00894
    Location:7291095
    PI3Kc_IB_gamma; Catalytic domain of Class IB Phosphoinositide 3-kinase gamma

Alternate Rn_Celera

Genomic

  1. AC_000074.1 Alternate Rn_Celera

    Range
    47971127..48004061 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017603163.1XP_017458652.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001106723.1: Suppressed sequence

    Description
    NM_001106723.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: PIK3CG (GeneID:5294).
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