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CPSF1 cleavage and polyadenylation specific factor 1 [ Homo sapiens (human) ]

Gene ID: 29894, updated on 7-Jul-2024

Summary

Official Symbol
CPSF1provided by HGNC
Official Full Name
cleavage and polyadenylation specific factor 1provided by HGNC
Primary source
HGNC:HGNC:2324
See related
Ensembl:ENSG00000071894 MIM:606027; AllianceGenome:HGNC:2324
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MYP27; CPSF160; P/cl.18; HSU37012
Summary
Cleavage and polyadenylation specificity factor (CPSF) is a multisubunit complex that plays a central role in 3-prime processing of pre-mRNAs. CPSF recognizes the AAUAAA signal in the pre-mRNA and interacts with other proteins to facilitate both RNA cleavage and poly(A) synthesis. CPSF1 is the largest subunit of the CPSF complex (Murthy and Manley, 1995 [PubMed 7590244]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in testis (RPKM 31.8), duodenum (RPKM 25.9) and 25 other tissues See more
Orthologs
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Genomic context

See CPSF1 in Genome Data Viewer
Location:
8q24.3
Exon count:
43
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (144393231..144409335, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (145562868..145579148, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (145618446..145634719, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19677 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:145583746-145584281 Neighboring gene solute carrier family 52 member 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:145589246-145589414 Neighboring gene uncharacterized LOC101928902 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr8:145593027-145593528 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:145595436-145595936 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19678 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28096 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19679 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19680 Neighboring gene aarF domain containing kinase 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:145613649-145614150 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:145619396-145619557 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:145620910-145621123 Neighboring gene microRNA 939 Neighboring gene microRNA 1234 Neighboring gene microRNA 6849 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28097 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19681 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19682 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28098 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:145638844-145639041 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:145639267-145640084 Neighboring gene uncharacterized LOC124902041 Neighboring gene solute carrier family 39 member 4 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:145647393-145648164 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:145648165-145648934 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:145651263-145652026 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19684 Neighboring gene VPS28 subunit of ESCRT-I

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Myopia 27
MedGen: C5394215 OMIM: 618827 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify cleavage and polyadenylation specific factor 1 (CPSF1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify cleavage and polyadenylation specific factor 1 (CPSF1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify cleavage and polyadenylation specific factor 1 (CPSF1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify cleavage and polyadenylation specific factor 1 (CPSF1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
cleavage and polyadenylation specificity factor subunit 1
Names
CPSF 160 kDa subunit
cleavage and polyadenylation specific factor 1, 160kDa
cleavage and polyadenylation specificity factor 160 kDa subunit
polyadenylation specificity factor
NP_037423.2
XP_006716611.1
XP_047277688.1
XP_047277689.1
XP_047277690.1
XP_047277691.1
XP_047277692.1
XP_054188162.1
XP_054188163.1
XP_054188164.1
XP_054188165.1
XP_054188166.1
XP_054188167.1
XP_054216355.1
XP_054216356.1
XP_054216357.1
XP_054216358.1
XP_054216359.1
XP_054216360.1
XP_054216361.1
XP_054216362.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013291.3NP_037423.2  cleavage and polyadenylation specificity factor subunit 1

    See identical proteins and their annotated locations for NP_037423.2

    Status: VALIDATED

    Source sequence(s)
    BC017232, CD299980
    Consensus CDS
    CCDS34966.1
    UniProtKB/Swiss-Prot
    Q10570, Q96AF0
    Related
    ENSP00000484669.1, ENST00000616140.2
    Conserved Domains (1) summary
    COG5161
    Location:11437
    SFT1; Pre-mRNA cleavage and polyadenylation specificity factor [RNA processing and modification]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    144393231..144409335 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006716548.3XP_006716611.1  cleavage and polyadenylation specificity factor subunit 1 isoform X1

    Conserved Domains (1) summary
    COG5161
    Location:11434
    SFT1; Pre-mRNA cleavage and polyadenylation specificity factor [RNA processing and modification]
  2. XM_047421733.1XP_047277689.1  cleavage and polyadenylation specificity factor subunit 1 isoform X2

  3. XM_047421735.1XP_047277691.1  cleavage and polyadenylation specificity factor subunit 1 isoform X2

  4. XM_047421734.1XP_047277690.1  cleavage and polyadenylation specificity factor subunit 1 isoform X2

  5. XM_047421732.1XP_047277688.1  cleavage and polyadenylation specificity factor subunit 1 isoform X2

  6. XM_047421736.1XP_047277692.1  cleavage and polyadenylation specificity factor subunit 1 isoform X3

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_018654716.1 Reference GRCh38.p14 PATCHES

    Range
    123834..139938 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054332187.1XP_054188162.1  cleavage and polyadenylation specificity factor subunit 1 isoform X1

  2. XM_054332191.1XP_054188166.1  cleavage and polyadenylation specificity factor subunit 1 isoform X2

  3. XM_054332190.1XP_054188165.1  cleavage and polyadenylation specificity factor subunit 1 isoform X2

  4. XM_054332189.1XP_054188164.1  cleavage and polyadenylation specificity factor subunit 1 isoform X2

  5. XM_054332188.1XP_054188163.1  cleavage and polyadenylation specificity factor subunit 1 isoform X2

  6. XM_054332192.1XP_054188167.1  cleavage and polyadenylation specificity factor subunit 1 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    145562868..145579148 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054360382.1XP_054216357.1  cleavage and polyadenylation specificity factor subunit 1 isoform X5

  2. XM_054360380.1XP_054216355.1  cleavage and polyadenylation specificity factor subunit 1 isoform X4

  3. XM_054360381.1XP_054216356.1  cleavage and polyadenylation specificity factor subunit 1 isoform X1

  4. XM_054360386.1XP_054216361.1  cleavage and polyadenylation specificity factor subunit 1 isoform X2

  5. XM_054360385.1XP_054216360.1  cleavage and polyadenylation specificity factor subunit 1 isoform X2

  6. XM_054360384.1XP_054216359.1  cleavage and polyadenylation specificity factor subunit 1 isoform X2

  7. XM_054360383.1XP_054216358.1  cleavage and polyadenylation specificity factor subunit 1 isoform X2

  8. XM_054360387.1XP_054216362.1  cleavage and polyadenylation specificity factor subunit 1 isoform X3