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RBM15B RNA binding motif protein 15B [ Homo sapiens (human) ]

Gene ID: 29890, updated on 4-Oct-2020

Summary

Official Symbol
RBM15Bprovided by HGNC
Official Full Name
RNA binding motif protein 15Bprovided by HGNC
Primary source
HGNC:HGNC:24303
See related
Ensembl:ENSG00000259956 MIM:612602
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OTT3; HsOTT3; HUMAGCGB
Summary
Members of the SPEN (Split-end) family of proteins, including RBM15B, have repressor function in several signaling pathways and may bind to RNA through interaction with spliceosome components (Hiriart et al., 2005 [PubMed 16129689]).[supplied by OMIM, Feb 2009]
Orthologs

Genomic context

See RBM15B in Genome Data Viewer
Location:
3p21.2
Exon count:
1
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (51391285..51397908)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (51428699..51435339)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene dedicator of cytokinesis 3 Neighboring gene ST13, Hsp70 interacting protein pseudogene 14 Neighboring gene DDB1 and CUL4 associated factor 1 Neighboring gene mesencephalic astrocyte derived neurotrophic factor Neighboring gene uncharacterized LOC105377085 Neighboring gene Sharpr-MPRA regulatory region 62 Neighboring gene RAD54 like 2

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag NXF1 upregulates the OTT3-mediated Gag expression from pNLgag-RTE, suggesting cooperation between OTT3 and NXF1 PubMed
integrase gag-pol Analysis of HIV-1 proviral integration sites in antiretroviral treatment patients indicates that RBM15B gene favors HIV-1 integration for expansion and persistence of infected cells, suggesting HIV-1 IN interacts with RBM15B PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA binding NAS
Non-traceable Author Statement
more info
PubMed 
nucleic acid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
RNA methylation IDA
Inferred from Direct Assay
more info
PubMed 
dosage compensation by inactivation of X chromosome IDA
Inferred from Direct Assay
more info
PubMed 
mRNA export from nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NOT negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
NOT nucleocytoplasmic transport IDA
Inferred from Direct Assay
more info
PubMed 
regulation of alternative mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of alternative mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
RNA N6-methyladenosine methyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
nuclear speck IDA
Inferred from Direct Assay
more info
PubMed 
NOT nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
putative RNA-binding protein 15B
Names
chromosome 3p21.1 gene sequence
huOTT3
one twenty two protein 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013286.5NP_037418.3  putative RNA-binding protein 15B

    See identical proteins and their annotated locations for NP_037418.3

    Status: VALIDATED

    Source sequence(s)
    AC092037, BM980577
    Consensus CDS
    CCDS33764.1
    UniProtKB/Swiss-Prot
    Q8NDT2
    Related
    ENSP00000454545.1, ENST00000563281.2
    Conserved Domains (5) summary
    cd12554
    Location:137218
    RRM1_RBM15B; RNA recognition motif 1 in putative RNA binding motif protein 15B (RBM15B) from vertebrate
    cd12556
    Location:329413
    RRM2_RBM15B; RNA recognition motif 2 in putative RNA binding motif protein 15B (RBM15B) from vertebrate
    cd12558
    Location:416491
    RRM3_RBM15B; RNA recognition motif 3 in putative RNA-binding protein 15B (RBM15B) from vertebrate
    pfam07744
    Location:712887
    SPOC; SPOC domain
    cl25887
    Location:529639
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    51391285..51397908
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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