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Mapre3 microtubule-associated protein, RP/EB family, member 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 298848, updated on 5-Sep-2025
Official Symbol
Mapre3provided by RGD
Official Full Name
microtubule-associated protein, RP/EB family, member 3provided by RGD
Primary source
RGD:1359297
See related
Ensembl:ENSRNOG00000008961 AllianceGenome:RGD:1359297
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable identical protein binding activity; microtubule plus-end binding activity; and protein kinase binding activity. Involved in behavioral response to cocaine and positive regulation of dendritic spine morphogenesis. Located in neuron to neuron synapse. Orthologous to human MAPRE3 (microtubule associated protein RP/EB family member 3). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Biased expression in Testes (RPKM 149.1), Brain (RPKM 111.2) and 9 other tissues See more
Orthologs
human mouse all
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See Mapre3 in Genome Data Viewer
Location:
6q14
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (31233736..31278626, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (25513800..25558876, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (26878738..26923459, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479111 Neighboring gene transmembrane protein 214 Neighboring gene uncharacterized LOC108351190 Neighboring gene uncharacterized LOC108351187 Neighboring gene 60S ribosomal protein L37 pseudogene Neighboring gene dihydropyrimidinase-like 5 Neighboring gene uncharacterized LOC120103488

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. PSD-95 alters microtubule dynamics via an association with EB3. Sweet ES, et al. J Neurosci, 2011 Jan 19. PMID 21248129, Free PMC Article
  2. The drebrin/EB3 pathway regulates cytoskeletal dynamics to drive neuritogenesis in embryonic cortical neurons. Poobalasingam T, et al. J Neurochem, 2022 Jan. PMID 34478582
  3. Synaptic Microtubule-Associated Protein EB3 and SRC Phosphorylation Mediate Structural and Behavioral Adaptations During Withdrawal From Cocaine Self-Administration. Calipari ES, et al. J Neurosci, 2019 Jul 17. PMID 31092585, Free PMC Article
  4. End-binding proteins EB3 and EB1 link microtubules to ankyrin G in the axon initial segment. Leterrier C, et al. Proc Natl Acad Sci U S A, 2011 May 24. PMID 21551097, Free PMC Article
  5. Microtubules that form the stationary lattice of muscle fibers are dynamic and nucleated at Golgi elements. Oddoux S, et al. J Cell Biol, 2013 Oct 28. PMID 24145165, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The drebrin/EB3 pathway regulates cytoskeletal dynamics to drive neuritogenesis in embryonic cortical neurons.
    Title: The drebrin/EB3 pathway regulates cytoskeletal dynamics to drive neuritogenesis in embryonic cortical neurons.
  2. EB3 and EB1 coordinate a molecular and functional interplay between ankyrin G (ankG)and the axon initial segment microtubules that supports the central role of ankG in the maintenance of neuronal polarity
    Title: End-binding proteins EB3 and EB1 link microtubules to ankyrin G in the axon initial segment.
  3. The interaction between PSD-95 and EB3 in determining dendritic morphology by regulation of microtubules elucidates a function for a novel region of EB3.
    Title: PSD-95 alters microtubule dynamics via an association with EB3.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Clone Names

  • MGC94312

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule plus-end binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule plus-end binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule plus-end binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine/threonine kinase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase binding IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in behavioral response to cocaine IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of dendritic spine morphogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein localization to microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of microtubule polymerization IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of microtubule polymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of microtubule polymerization or depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasmic microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
colocalizes_with microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule end IEA
Inferred from Electronic Annotation
more info
  
is_active_in microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microtubule plus-end IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule plus-end IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule plus-end ISO
Inferred from Sequence Orthology
more info
  
located_in midbody IEA
Inferred from Electronic Annotation
more info
  
located_in midbody ISO
Inferred from Sequence Orthology
more info
  
located_in mitotic spindle astral microtubule end IEA
Inferred from Electronic Annotation
more info
  
located_in mitotic spindle astral microtubule end ISO
Inferred from Sequence Orthology
more info
  
located_in neuron to neuron synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in spindle midzone IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
microtubule-associated protein RP/EB family member 3
Names
EB1 protein family member 3
EB3
EBF3
RP3
end-binding protein 3

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007656.1 → NP_001007657.1  microtubule-associated protein RP/EB family member 3

    See identical proteins and their annotated locations for NP_001007657.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083589
    UniProtKB/Swiss-Prot
    Q5XIT1
    Related
    ENSRNOP00000011877.2, ENSRNOT00000011874.6
    Conserved Domains (1) summary
    COG5217
    Location:16 → 279
    BIM1; Microtubule-binding protein involved in cell cycle control [Cell division and chromosome partitioning / Cytoskeleton]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    31233736..31278626 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008764513.4 → XP_008762735.1  microtubule-associated protein RP/EB family member 3 isoform X2

    See identical proteins and their annotated locations for XP_008762735.1

    UniProtKB/TrEMBL
    A0A8I6A6V2
    Related
    ENSRNOP00000088597.1, ENSRNOT00000113201.2
    Conserved Domains (1) summary
    COG5217
    Location:16 → 264
    BIM1; Microtubule-binding protein involved in cell cycle control [Cell division and chromosome partitioning / Cytoskeleton]

  2. XM_008764512.4 → XP_008762734.1  microtubule-associated protein RP/EB family member 3 isoform X1

    See identical proteins and their annotated locations for XP_008762734.1

    UniProtKB/Swiss-Prot
    Q5XIT1
    Conserved Domains (1) summary
    COG5217
    Location:16 → 279
    BIM1; Microtubule-binding protein involved in cell cycle control [Cell division and chromosome partitioning / Cytoskeleton]

  3. XM_039111914.2 → XP_038967842.1  microtubule-associated protein RP/EB family member 3 isoform X1

    UniProtKB/Swiss-Prot
    Q5XIT1
    Conserved Domains (1) summary
    COG5217
    Location:16 → 279
    BIM1; Microtubule-binding protein involved in cell cycle control [Cell division and chromosome partitioning / Cytoskeleton]

RNA

  1. XR_010052059.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XIT1.1 GenPept UniProtKB/Swiss-Prot:Q5XIT1

Gene LinkOut

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