Dync2li1 dynein cytoplasmic 2 light intermediate chain 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dync2li1provided by RGD
Official Full Name: dynein cytoplasmic 2 light intermediate chain 1provided by RGD
Primary source: RGD:1310286
See related: Ensembl:ENSRNOG00000005151 AllianceGenome:RGD:1310286
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1310286
Summary: Enables dynein heavy chain binding activity. Predicted to be involved in intraciliary retrograde transport; intraciliary transport involved in cilium assembly; and regulation of cilium assembly. Predicted to act upstream of or within cilium assembly and determination of left/right symmetry. Predicted to be located in several cellular components, including centrosome; ciliary transition zone; and motile cilium. Predicted to be part of cytoplasmic dynein complex. Predicted to be active in axoneme and ciliary basal body. Predicted to colocalize with cytoplasmic microtubule. Human ortholog(s) of this gene implicated in asphyxiating thoracic dystrophy. Orthologous to human DYNC2LI1 (dynein cytoplasmic 2 light intermediate chain 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Testes (RPKM 141.5), Kidney (RPKM 88.8) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q12

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (15745350..15778166, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (9992537..10025355, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (7900962..7933795)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables dynein heavy chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables dynein heavy chain binding	IEA Inferred from Electronic Annotation more info
enables dynein heavy chain binding	IPI Inferred from Physical Interaction more info	PubMed
enables dynein heavy chain binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in determination of left/right symmetry	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within determination of left/right symmetry	ISO Inferred from Sequence Orthology more info
involved_in intraciliary retrograde transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intraciliary retrograde transport	IEA Inferred from Electronic Annotation more info
involved_in intraciliary transport involved in cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in intraciliary transport involved in cilium assembly	IEA Inferred from Electronic Annotation more info
involved_in intraciliary transport involved in cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in intraciliary transport involved in cilium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cilium assembly	IEA Inferred from Electronic Annotation more info
involved_in regulation of cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of cilium assembly	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in apical part of cell	IEA Inferred from Electronic Annotation more info
located_in apical part of cell	ISO Inferred from Sequence Orthology more info
is_active_in axoneme	IBA Inferred from Biological aspect of Ancestor more info
located_in axoneme	IEA Inferred from Electronic Annotation more info
located_in axoneme	ISO Inferred from Sequence Orthology more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISS Inferred from Sequence or Structural Similarity more info
is_active_in ciliary basal body	IBA Inferred from Biological aspect of Ancestor more info
located_in ciliary basal body	IEA Inferred from Electronic Annotation more info
located_in ciliary basal body	ISO Inferred from Sequence Orthology more info
located_in ciliary basal body	ISS Inferred from Sequence or Structural Similarity more info
located_in ciliary transition zone	IEA Inferred from Electronic Annotation more info
located_in ciliary transition zone	ISO Inferred from Sequence Orthology more info
located_in ciliary transition zone	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
part_of cytoplasmic dynein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cytoplasmic dynein complex	IEA Inferred from Electronic Annotation more info
part_of cytoplasmic dynein complex	ISO Inferred from Sequence Orthology more info
part_of cytoplasmic dynein complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in motile cilium	IEA Inferred from Electronic Annotation more info
located_in motile cilium	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cytoplasmic dynein 2 light intermediate chain 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001395083.1 → NP_001382012.1 cytoplasmic dynein 2 light intermediate chain 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/Swiss-Prot

Q6AY43

UniProtKB/TrEMBL

A0A8I5ZPI1

Related

ENSRNOP00000006953.4, ENSRNOT00000006953.7

Conserved Domains (1) summary

pfam05783
Location:2 → 268

DLIC; Dynein light intermediate chain (DLIC)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

15745350..15778166 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001013940.1: Suppressed sequence

Description

NM_001013940.1: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.