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Ulk2 unc-51 like kinase 2 [ Mus musculus (house mouse) ]

Gene ID: 29869, updated on 24-Jan-2023

Summary

Official Symbol
Ulk2provided by MGI
Official Full Name
unc-51 like kinase 2provided by MGI
Primary source
MGI:MGI:1352758
See related
Ensembl:ENSMUSG00000004798 AllianceGenome:MGI:1352758
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Unc51.2; mKIAA0623; A830085I22Rik
Summary
Enables protein serine/threonine kinase activity. Involved in autophagy and response to starvation. Acts upstream of or within axon extension and negative regulation of collateral sprouting. Located in phagophore assembly site membrane. Is expressed in facial bone primordium; nervous system; and sensory organ. Orthologous to human ULK2 (unc-51 like autophagy activating kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 33.4), CNS E18 (RPKM 21.5) and 26 other tissues See more
Orthologs
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Genomic context

See Ulk2 in Genome Data Viewer
Location:
11; 11 B2
Exon count:
28
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (61666424..61750754, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (61775598..61855334, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 5 (sodium/glucose cotransporter), member 10 Neighboring gene family with sequence similarity 83, member G Neighboring gene phosphoribosyl pyrophosphate synthetase-associated protein 2 Neighboring gene A kinase (PRKA) anchor protein 10 Neighboring gene predicted gene, 23721

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in autophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in axon extension IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within axon extension IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in axonogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of collateral sprouting IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in late nucleophagy IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of collateral sprouting IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within negative regulation of collateral sprouting IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in piecemeal microautophagy of the nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in response to starvation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in reticulophagy IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in autophagosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in phagophore assembly site IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in phagophore assembly site membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in phagophore assembly site membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase ULK2
Names
serine/threonine-protein kinase Unc51.2
NP_038909.3
XP_006533571.1
XP_006533572.1
XP_030101926.1
XP_036012644.1
XP_036012645.1
XP_036012646.1
XP_036012647.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013881.4NP_038909.3  serine/threonine-protein kinase ULK2

    See identical proteins and their annotated locations for NP_038909.3

    Status: VALIDATED

    Source sequence(s)
    AK146620, AK148142, AV256860, BM124275
    Consensus CDS
    CCDS24820.1
    UniProtKB/Swiss-Prot
    Q9QY01, Q9WTP4
    UniProtKB/TrEMBL
    Q3UG39
    Related
    ENSMUSP00000004920.4, ENSMUST00000004920.4
    Conserved Domains (3) summary
    smart00220
    Location:9271
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14201
    Location:2272
    STKc_ULK2; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 2
    pfam12063
    Location:8651030
    DUF3543; Domain of unknown function (DUF3543)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    61666424..61750754 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156753.1XP_036012646.1  serine/threonine-protein kinase ULK2 isoform X6

    Conserved Domains (2) summary
    pfam12063
    Location:725912
    DUF3543; Domain of unknown function (DUF3543)
    cl21453
    Location:1154
    PKc_like; Protein Kinases, catalytic domain
  2. XM_036156752.1XP_036012645.1  serine/threonine-protein kinase ULK2 isoform X5

    Conserved Domains (2) summary
    pfam12063
    Location:725904
    DUF3543; Domain of unknown function (DUF3543)
    cl21453
    Location:1154
    PKc_like; Protein Kinases, catalytic domain
  3. XM_036156751.1XP_036012644.1  serine/threonine-protein kinase ULK2 isoform X2

    Conserved Domains (2) summary
    pfam12063
    Location:809988
    DUF3543; Domain of unknown function (DUF3543)
    cl21453
    Location:2238
    PKc_like; Protein Kinases, catalytic domain
  4. XM_030246066.2XP_030101926.1  serine/threonine-protein kinase ULK2 isoform X4

    Conserved Domains (2) summary
    cd14201
    Location:2272
    STKc_ULK2; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 2
    pfam12063
    Location:802984
    DUF3543; Domain of unknown function (DUF3543)
  5. XM_006533509.5XP_006533572.1  serine/threonine-protein kinase ULK2 isoform X3

    Conserved Domains (2) summary
    cd14201
    Location:2272
    STKc_ULK2; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 2
    pfam12063
    Location:802973
    DUF3543; Domain of unknown function (DUF3543)
  6. XM_036156754.1XP_036012647.1  serine/threonine-protein kinase ULK2 isoform X7

    Conserved Domains (1) summary
    pfam12063
    Location:367546
    DUF3543; Domain of unknown function (DUF3543)
  7. XM_006533508.5XP_006533571.1  serine/threonine-protein kinase ULK2 isoform X1

    Conserved Domains (2) summary
    cd14201
    Location:2272
    STKc_ULK2; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 2
    pfam12063
    Location:8481019
    DUF3543; Domain of unknown function (DUF3543)