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Nasp nuclear autoantigenic sperm protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 298441, updated on 4-Nov-2022

Summary

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Official Symbol
Naspprovided by RGD
Official Full Name
nuclear autoantigenic sperm proteinprovided by RGD
Primary source
RGD:1359609
See related
Ensembl:ENSRNOG00000016454 AllianceGenome:RGD:1359609
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable histone binding activity. Involved in male gonad development and response to testosterone. Predicted to be located in chromatin; cytoplasm; and nucleus. Predicted to be part of protein-containing complex. Predicted to be active in nucleoplasm. Orthologous to human NASP (nuclear autoantigenic sperm protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 602.7), Thymus (RPKM 232.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nasp in Genome Data Viewer
Location:
5q35
Exon count:
18
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (130057363..130083003, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (135446485..135472113, complement)

Chromosome 5 - NC_051340.1Genomic Context describing neighboring genes Neighboring gene GC-rich promoter binding protein 1-like 1 Neighboring gene coiled-coil domain containing 17 Neighboring gene aldo-keto reductase family 1 member A1 Neighboring gene U6 spliceosomal RNA Neighboring gene peroxiredoxin 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Proteomic changes in rat spermatogenesis in response to in vivo androgen manipulation; impact on meiotic cells. Stanton PG, et al. PLoS One, 2012. PMID 22860010, Free PMC Article
  2. The antibody against a nuclear autoantigenic sperm protein can result in reproductive failure. Wang M, et al. Asian J Androl, 2009 Mar. PMID 19219058, Free PMC Article
  3. Nuclear autoantigenic sperm protein (NASP), a linker histone chaperone that is required for cell proliferation. Richardson RT, et al. J Biol Chem, 2006 Jul 28. PMID 16728391
  4. Overexpression of the Linker histone-binding protein tNASP affects progression through the cell cycle. Alekseev OM, et al. J Biol Chem, 2003 Mar 7. PMID 12509435
  5. Analysis of the expression of human tumor antigens in ovarian cancer tissues. Ali-Fehmi R, et al. Cancer Biomark, 2010. PMID 20164540, Free PMC Article

See all (14) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. an increase of miR-29a, and hence decrease of Nasp, may contribute to inhibit cell proliferation during postnatal organ development.
    Title: MicroRNA-29a inhibited epididymal epithelial cell proliferation by targeting nuclear autoantigenic sperm protein (NASP).
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC93869

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables histone binding ISO
Inferred from Sequence Orthology
more info
  
enables histone binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables histone chaperone activity ISO
Inferred from Sequence Orthology
more info
  
enables histone chaperone activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in CENP-A containing chromatin assembly IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication-dependent chromatin assembly IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
acts_upstream_of_or_within DNA replication-dependent chromatin assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA replication-dependent chromatin assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within DNA replication-dependent chromatin assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in DNA replication-dependent chromatin assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in blastocyst development ISO
Inferred from Sequence Orthology
more info
  
involved_in blastocyst development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in chromatin organization ISO
Inferred from Sequence Orthology
more info
  
involved_in male gonad development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in nucleosome assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in response to testosterone IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
nuclear autoantigenic sperm protein
Names
nuclear autoantigenic sperm protein (histone-binding)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005543.1 → NP_001005543.1  nuclear autoantigenic sperm protein

    See identical proteins and their annotated locations for NP_001005543.1

    Status: PROVISIONAL

    Source sequence(s)
    BC081913
    UniProtKB/Swiss-Prot
    Q66HD3
    Related
    ENSRNOP00000022170.4, ENSRNOT00000022170.6
    Conserved Domains (4) summary
    COG5271
    Location:130 → 493
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    sd00006
    Location:530 → 558
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:528 → 604
    TPR_12; Tetratricopeptide repeat
    pfam10516
    Location:530 → 567
    SHNi-TPR

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051340.1 Reference mRatBN7.2 Primary Assembly

    Range
    130057363..130083003 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006238646.4 → XP_006238708.1  nuclear autoantigenic sperm protein isoform X1

    See identical proteins and their annotated locations for XP_006238708.1

    UniProtKB/Swiss-Prot
    Q66HD3
    Conserved Domains (4) summary
    COG5271
    Location:130 → 493
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    sd00006
    Location:530 → 558
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:528 → 604
    TPR_12; Tetratricopeptide repeat
    pfam10516
    Location:530 → 567
    SHNi-TPR

  2. XM_008763993.3 → XP_008762215.1  nuclear autoantigenic sperm protein isoform X1

    See identical proteins and their annotated locations for XP_008762215.1

    UniProtKB/Swiss-Prot
    Q66HD3
    Conserved Domains (4) summary
    COG5271
    Location:130 → 493
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    sd00006
    Location:530 → 558
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:528 → 604
    TPR_12; Tetratricopeptide repeat
    pfam10516
    Location:530 → 567
    SHNi-TPR

  3. XM_039109600.1 → XP_038965528.1  nuclear autoantigenic sperm protein isoform X1

    UniProtKB/Swiss-Prot
    Q66HD3
    Conserved Domains (4) summary
    COG5271
    Location:130 → 493
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    sd00006
    Location:530 → 558
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:528 → 604
    TPR_12; Tetratricopeptide repeat
    pfam10516
    Location:530 → 567
    SHNi-TPR

  4. XM_017593276.2 → XP_017448765.1  nuclear autoantigenic sperm protein isoform X2

    Related
    ENSRNOP00000078719.1, ENSRNOT00000099538.1

  5. XM_006238647.4 → XP_006238709.1  nuclear autoantigenic sperm protein isoform X3

    UniProtKB/TrEMBL
    A0A8I6AFA6
    Related
    ENSRNOP00000091359.1, ENSRNOT00000119622.1
    Conserved Domains (3) summary
    sd00006
    Location:203 → 231
    TPR; TPR repeat [structural motif]
    pfam10516
    Location:203 → 240
    SHNi-TPR; SHNi-TPR
    pfam13424
    Location:200 → 277
    TPR_12; Tetratricopeptide repeat
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q66HD3.1 GenPept UniProtKB/Swiss-Prot:Q66HD3

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