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Echdc2 enoyl CoA hydratase domain containing 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 298381, updated on 27-Nov-2024

Summary

Official Symbol
Echdc2provided by RGD
Official Full Name
enoyl CoA hydratase domain containing 2provided by RGD
Primary source
RGD:1308525
See related
EnsemblRapid:ENSRNOG00000029333 AllianceGenome:RGD:1308525
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1308525
Summary
Predicted to enable catalytic activity. Predicted to be involved in fatty acid beta-oxidation. Predicted to be active in mitochondrion. Orthologous to human ECHDC2 (enoyl-CoA hydratase domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 186.3), Kidney (RPKM 133.1) and 8 other tissues See more
Orthologs
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Genomic context

See Echdc2 in Genome Data Viewer
Location:
5q34
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (128144241..128163611)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (122915874..122934860)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (127770570..127789568)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene sterol carrier protein 2 Neighboring gene zyg-11 family member A, cell cycle regulator Neighboring gene basic transcription factor 3, pseudogene 13 Neighboring gene zyg-11 family member B, cell cycle regulator

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in fatty acid beta-oxidation IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
enoyl-CoA hydratase domain-containing protein 2, mitochondrial
Names
enoyl Coenzyme A hydratase domain containing 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106675.1NP_001100145.1  enoyl-CoA hydratase domain-containing protein 2, mitochondrial

    See identical proteins and their annotated locations for NP_001100145.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474008
    UniProtKB/TrEMBL
    A0A8I5ZUZ9, A6JYU2, D3ZIL6
    Related
    ENSRNOP00000049726.3, ENSRNOT00000047653.5
    Conserved Domains (1) summary
    cl23717
    Location:42296
    crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    128144241..128163611
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063287394.1XP_063143464.1  enoyl-CoA hydratase domain-containing protein 2, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZV01
    Related
    ENSRNOP00000082488.1, ENSRNOT00000096852.2
  2. XM_063287395.1XP_063143465.1  enoyl-CoA hydratase domain-containing protein 2, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZV01
  3. XM_039109577.2XP_038965505.1  enoyl-CoA hydratase domain-containing protein 2, mitochondrial isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZUZ9
    Conserved Domains (1) summary
    cl23717
    Location:45244
    crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
  4. XM_006238507.3XP_006238569.1  enoyl-CoA hydratase domain-containing protein 2, mitochondrial isoform X3

    See identical proteins and their annotated locations for XP_006238569.1

    UniProtKB/TrEMBL
    A6JYU3
    Conserved Domains (1) summary
    cl23717
    Location:1191
    crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

RNA

  1. XR_005504398.2 RNA Sequence

  2. XR_005504399.2 RNA Sequence

  3. XR_005504400.2 RNA Sequence