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Tnfrsf19 tumor necrosis factor receptor superfamily, member 19 [ Mus musculus (house mouse) ]

Gene ID: 29820, updated on 5-Mar-2024

Summary

Official Symbol
Tnfrsf19provided by MGI
Official Full Name
tumor necrosis factor receptor superfamily, member 19provided by MGI
Primary source
MGI:MGI:1352474
See related
Ensembl:ENSMUSG00000060548 AllianceGenome:MGI:1352474
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TAJ; Troy; TRADE; TAJ-ALPHA
Summary
Predicted to enable signaling receptor activity. Acts upstream of or within hair follicle development and positive regulation of I-kappaB kinase/NF-kappaB signaling. Predicted to be located in extracellular region and membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; brain; embryo mesenchyme; integumental system; and respiratory system. Orthologous to human TNFRSF19 (TNF receptor superfamily member 19). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in adrenal adult (RPKM 14.8), CNS E11.5 (RPKM 12.6) and 21 other tissues See more
Orthologs
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Genomic context

See Tnfrsf19 in Genome Data Viewer
Location:
14 D1; 14 32.06 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (61201283..61284304, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (60963834..61046855, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr14:61418588-61418889 Neighboring gene C1q and tumor necrosis factor related protein 9 Neighboring gene mitochondrial intermediate peptidase, opposite strand Neighboring gene mitochondrial intermediate peptidase Neighboring gene STARR-seq mESC enhancer starr_36865 Neighboring gene STARR-seq mESC enhancer starr_36867 Neighboring gene STARR-seq mESC enhancer starr_36869 Neighboring gene STARR-seq mESC enhancer starr_36870 Neighboring gene VISTA enhancer mm7 Neighboring gene STARR-seq mESC enhancer starr_36873 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:61665054-61665237 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:61675420-61675649 Neighboring gene predicted gene, 41167 Neighboring gene predicted gene, 41168 Neighboring gene STARR-positive B cell enhancer ABC_E8562 Neighboring gene sacsin Neighboring gene sarcoglycan, gamma (dystrophin-associated glycoprotein)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tumor necrosis factor receptor superfamily member 19
Names
Toxicity and JNK inducer

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164155.1NP_001157627.1  tumor necrosis factor receptor superfamily member 19 precursor

    See identical proteins and their annotated locations for NP_001157627.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and represents use of an alternate promoter, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK083283, BB526959, BB858206, BY637570, CB244999
    Consensus CDS
    CCDS36941.1
    UniProtKB/Swiss-Prot
    Q80T13, Q812G3, Q9JHF1, Q9JJH6, Q9JLL2, Q9JLL3, Q9QXW7
    UniProtKB/TrEMBL
    Q8BUM7
    Related
    ENSMUSP00000106867.3, ENSMUST00000111236.4
    Conserved Domains (1) summary
    cd13418
    Location:33149
    TNFRSF19; Tumor necrosis factor receptor superfamily member 19 (TNFRSF19), also known as TROY
  2. NM_013869.5NP_038897.4  tumor necrosis factor receptor superfamily member 19 precursor

    See identical proteins and their annotated locations for NP_038897.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK028146, AK083283, BY637570, CF727607
    Consensus CDS
    CCDS36941.1
    UniProtKB/Swiss-Prot
    Q80T13, Q812G3, Q9JHF1, Q9JJH6, Q9JLL2, Q9JLL3, Q9QXW7
    UniProtKB/TrEMBL
    Q8BUM7
    Related
    ENSMUSP00000106865.3, ENSMUST00000111234.10
    Conserved Domains (1) summary
    cd13418
    Location:33149
    TNFRSF19; Tumor necrosis factor receptor superfamily member 19 (TNFRSF19), also known as TROY

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    61201283..61284304 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158664.1XP_036014557.1  tumor necrosis factor receptor superfamily member 19 isoform X1

    UniProtKB/TrEMBL
    Q8BWR1
    Conserved Domains (1) summary
    cl22855
    Location:117
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)