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Stau2 staufen double-stranded RNA binding protein 2 [ Mus musculus (house mouse) ]

Gene ID: 29819, updated on 12-May-2024

Summary

Official Symbol
Stau2provided by MGI
Official Full Name
staufen double-stranded RNA binding protein 2provided by MGI
Primary source
MGI:MGI:1352508
See related
Ensembl:ENSMUSG00000025920 AllianceGenome:MGI:1352508
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable several functions, including Hsp70 protein binding activity; kinesin binding activity; and mitogen-activated protein kinase binding activity. Predicted to be involved in several processes, including anterograde dendritic transport of messenger ribonucleoprotein complex; positive regulation of long-term synaptic depression; and positive regulation of nervous system development. Predicted to be located in several cellular components, including cytoplasmic stress granule; dendritic shaft; and nuclear membrane. Predicted to be part of messenger ribonucleoprotein complex. Is expressed in several structures, including central nervous system; olfactory epithelium; retina; submandibular gland primordium; and tooth. Orthologous to human STAU2 (staufen double-stranded RNA binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 14.6), cortex adult (RPKM 11.5) and 14 other tissues See more
Orthologs
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Genomic context

See Stau2 in Genome Data Viewer
Location:
1 A3; 1 5.05 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (16299027..16591228, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (16228803..16520332, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:16094431-16094614 Neighboring gene retinol dehydrogenase 10 (all-trans) Neighboring gene ribosomal protein L7 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:16167808-16168008 Neighboring gene RIKEN cDNA C130013N14 gene Neighboring gene predicted gene 7568 Neighboring gene ubiquitin-conjugating enzyme E2W (putative) Neighboring gene STARR-positive B cell enhancer ABC_E4305 Neighboring gene STARR-positive B cell enhancer ABC_E5743 Neighboring gene elongin C

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 
  • Targeted (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Hsp70 protein binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables double-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables double-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables kinesin binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables mitogen-activated protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables ribosome binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasmic stress granule IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasmic stress granule ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic shaft ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
part_of messenger ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
double-stranded RNA-binding protein Staufen homolog 2
Names
staufen (RNA binding protein) homolog 2
staufen 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001111272.1NP_001104742.1  double-stranded RNA-binding protein Staufen homolog 2 isoform 2

    See identical proteins and their annotated locations for NP_001104742.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate segment in the 5' end, compared to variant 1. This difference causes translation initiation at an upstream AUG and a protein (isoform 2) with a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK031102, BI987531, BY290411, CN665159
    Consensus CDS
    CCDS48223.1
    UniProtKB/TrEMBL
    E2QRQ3
    Related
    ENSMUSP00000027052.7, ENSMUST00000027052.13
    Conserved Domains (5) summary
    pfam16482
    Location:433491
    Staufen_C; Staufen C-terminal domain
    cd19882
    Location:66147
    DSRM_STAU2_rpt2; second double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
    cd19884
    Location:174240
    DSRM_STAU2_rpt3; third double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
    cd19886
    Location:272357
    DSRM_STAU2_rpt4; fourth double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
    cl00054
    Location:638
    DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily
  2. NM_001347044.1NP_001333973.1  double-stranded RNA-binding protein Staufen homolog 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC115952, AC116695, AC162448
    Consensus CDS
    CCDS83528.1
    UniProtKB/TrEMBL
    D3Z6D2, E2QRQ3
    Related
    ENSMUSP00000122410.3, ENSMUST00000128957.9
  3. NM_001347045.1NP_001333974.1  double-stranded RNA-binding protein Staufen homolog 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC115952, AC116695, AC162448
    Consensus CDS
    CCDS83529.1
    UniProtKB/TrEMBL
    E2QRQ3
    Related
    ENSMUSP00000124303.2, ENSMUST00000162007.8
    Conserved Domains (5) summary
    pfam16482
    Location:433479
    Staufen_C; Staufen C-terminal domain
    cd19882
    Location:66147
    DSRM_STAU2_rpt2; second double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
    cd19884
    Location:174240
    DSRM_STAU2_rpt3; third double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
    cd19886
    Location:272357
    DSRM_STAU2_rpt4; fourth double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
    cl00054
    Location:638
    DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily
  4. NM_025303.3NP_079579.2  double-stranded RNA-binding protein Staufen homolog 2 isoform 3

    See identical proteins and their annotated locations for NP_079579.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has multiple differences in the presence and absence of exons, compared to variant 1. These differences produce a unique 5' UTR and cause translation initiation at a downstream start codon, compared to variant 1. The encoded protein (isoform 3) is shorter than isoform 1.
    Source sequence(s)
    AC115952, AC116695, AC162448, AC167117
    Consensus CDS
    CCDS14831.2
    UniProtKB/Swiss-Prot
    Q8BSY8, Q8CJ66, Q8CJ67, Q8R175, Q91Z19, Q9D5N7
    UniProtKB/TrEMBL
    E2QRQ3
    Related
    ENSMUSP00000124505.2, ENSMUST00000162751.8
    Conserved Domains (5) summary
    pfam16482
    Location:465523
    Staufen_C; Staufen C-terminal domain
    cd19880
    Location:370
    DSRM_STAU2_rpt1; first double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
    cd19882
    Location:98179
    DSRM_STAU2_rpt2; second double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
    cd19884
    Location:206272
    DSRM_STAU2_rpt3; third double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
    cd19886
    Location:304389
    DSRM_STAU2_rpt4; fourth double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    16299027..16591228 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006495532.5XP_006495595.1  double-stranded RNA-binding protein Staufen homolog 2 isoform X3

    See identical proteins and their annotated locations for XP_006495595.1

    UniProtKB/TrEMBL
    E2QRQ3
    Related
    ENSMUSP00000123827.2, ENSMUST00000162435.8
    Conserved Domains (5) summary
    pfam16482
    Location:433491
    Staufen_C; Staufen C-terminal domain
    cd19882
    Location:66147
    DSRM_STAU2_rpt2; second double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
    cd19884
    Location:174240
    DSRM_STAU2_rpt3; third double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
    cd19886
    Location:272357
    DSRM_STAU2_rpt4; fourth double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
    cl00054
    Location:638
    DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily
  2. XM_006495528.5XP_006495591.1  double-stranded RNA-binding protein Staufen homolog 2 isoform X1

    See identical proteins and their annotated locations for XP_006495591.1

    UniProtKB/Swiss-Prot
    Q8BSY8, Q8CJ66, Q8CJ67, Q8R175, Q91Z19, Q9D5N7
    UniProtKB/TrEMBL
    E2QRQ3
    Conserved Domains (5) summary
    pfam16482
    Location:465523
    Staufen_C; Staufen C-terminal domain
    cd19880
    Location:370
    DSRM_STAU2_rpt1; first double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
    cd19882
    Location:98179
    DSRM_STAU2_rpt2; second double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
    cd19884
    Location:206272
    DSRM_STAU2_rpt3; third double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
    cd19886
    Location:304389
    DSRM_STAU2_rpt4; fourth double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
  3. XM_011238390.3XP_011236692.1  double-stranded RNA-binding protein Staufen homolog 2 isoform X4

    UniProtKB/TrEMBL
    E2QRQ3
    Conserved Domains (5) summary
    pfam16482
    Location:465511
    Staufen_C; Staufen C-terminal domain
    cd19880
    Location:370
    DSRM_STAU2_rpt1; first double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
    cd19882
    Location:98179
    DSRM_STAU2_rpt2; second double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
    cd19884
    Location:206272
    DSRM_STAU2_rpt3; third double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
    cd19886
    Location:304389
    DSRM_STAU2_rpt4; fourth double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
  4. XM_017321109.3XP_017176598.1  double-stranded RNA-binding protein Staufen homolog 2 isoform X5

    UniProtKB/TrEMBL
    E2QRQ3
    Conserved Domains (5) summary
    pfam16482
    Location:433479
    Staufen_C; Staufen C-terminal domain
    cd19882
    Location:66147
    DSRM_STAU2_rpt2; second double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
    cd19884
    Location:174240
    DSRM_STAU2_rpt3; third double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
    cd19886
    Location:272357
    DSRM_STAU2_rpt4; fourth double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
    cl00054
    Location:638
    DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily
  5. XM_017321102.3XP_017176591.1  double-stranded RNA-binding protein Staufen homolog 2 isoform X1

    UniProtKB/Swiss-Prot
    Q8BSY8, Q8CJ66, Q8CJ67, Q8R175, Q91Z19, Q9D5N7
    UniProtKB/TrEMBL
    E2QRQ3
    Conserved Domains (5) summary
    pfam16482
    Location:465523
    Staufen_C; Staufen C-terminal domain
    cd19880
    Location:370
    DSRM_STAU2_rpt1; first double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
    cd19882
    Location:98179
    DSRM_STAU2_rpt2; second double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
    cd19884
    Location:206272
    DSRM_STAU2_rpt3; third double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
    cd19886
    Location:304389
    DSRM_STAU2_rpt4; fourth double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
  6. XM_011238387.2XP_011236689.1  double-stranded RNA-binding protein Staufen homolog 2 isoform X1

    See identical proteins and their annotated locations for XP_011236689.1

    UniProtKB/Swiss-Prot
    Q8BSY8, Q8CJ66, Q8CJ67, Q8R175, Q91Z19, Q9D5N7
    UniProtKB/TrEMBL
    E2QRQ3
    Conserved Domains (5) summary
    pfam16482
    Location:465523
    Staufen_C; Staufen C-terminal domain
    cd19880
    Location:370
    DSRM_STAU2_rpt1; first double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
    cd19882
    Location:98179
    DSRM_STAU2_rpt2; second double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
    cd19884
    Location:206272
    DSRM_STAU2_rpt3; third double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
    cd19886
    Location:304389
    DSRM_STAU2_rpt4; fourth double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
  7. XM_036165647.1XP_036021540.1  double-stranded RNA-binding protein Staufen homolog 2 isoform X3

    UniProtKB/TrEMBL
    E2QRQ3
    Conserved Domains (5) summary
    pfam16482
    Location:433491
    Staufen_C; Staufen C-terminal domain
    cd19882
    Location:66147
    DSRM_STAU2_rpt2; second double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
    cd19884
    Location:174240
    DSRM_STAU2_rpt3; third double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
    cd19886
    Location:272357
    DSRM_STAU2_rpt4; fourth double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
    cl00054
    Location:638
    DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily
  8. XM_036165648.1XP_036021541.1  double-stranded RNA-binding protein Staufen homolog 2 isoform X3

    UniProtKB/TrEMBL
    E2QRQ3
    Conserved Domains (5) summary
    pfam16482
    Location:433491
    Staufen_C; Staufen C-terminal domain
    cd19882
    Location:66147
    DSRM_STAU2_rpt2; second double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
    cd19884
    Location:174240
    DSRM_STAU2_rpt3; third double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
    cd19886
    Location:272357
    DSRM_STAU2_rpt4; fourth double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
    cl00054
    Location:638
    DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily
  9. XM_011238389.3XP_011236691.1  double-stranded RNA-binding protein Staufen homolog 2 isoform X3

    See identical proteins and their annotated locations for XP_011236691.1

    UniProtKB/TrEMBL
    E2QRQ3
    Conserved Domains (5) summary
    pfam16482
    Location:433491
    Staufen_C; Staufen C-terminal domain
    cd19882
    Location:66147
    DSRM_STAU2_rpt2; second double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
    cd19884
    Location:174240
    DSRM_STAU2_rpt3; third double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
    cd19886
    Location:272357
    DSRM_STAU2_rpt4; fourth double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
    cl00054
    Location:638
    DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily
  10. XM_030254814.2XP_030110674.1  double-stranded RNA-binding protein Staufen homolog 2 isoform X1

    UniProtKB/Swiss-Prot
    Q8BSY8, Q8CJ66, Q8CJ67, Q8R175, Q91Z19, Q9D5N7
    UniProtKB/TrEMBL
    E2QRQ3
    Conserved Domains (5) summary
    pfam16482
    Location:465523
    Staufen_C; Staufen C-terminal domain
    cd19880
    Location:370
    DSRM_STAU2_rpt1; first double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
    cd19882
    Location:98179
    DSRM_STAU2_rpt2; second double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
    cd19884
    Location:206272
    DSRM_STAU2_rpt3; third double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
    cd19886
    Location:304389
    DSRM_STAU2_rpt4; fourth double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
  11. XM_011238388.3XP_011236690.1  double-stranded RNA-binding protein Staufen homolog 2 isoform X2

    UniProtKB/TrEMBL
    E2QRQ3
    Conserved Domains (5) summary
    pfam16482
    Location:465512
    Staufen_C; Staufen C-terminal domain
    cd19880
    Location:370
    DSRM_STAU2_rpt1; first double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
    cd19882
    Location:98179
    DSRM_STAU2_rpt2; second double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
    cd19884
    Location:206272
    DSRM_STAU2_rpt3; third double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins
    cd19886
    Location:304389
    DSRM_STAU2_rpt4; fourth double-stranded RNA binding motif of double-stranded RNA-binding protein Staufen homolog 2 (Staufen 2) and similar proteins