Frem1 Fras1 related extracellular matrix 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Frem1provided by RGD
Official Full Name: Fras1 related extracellular matrix 1provided by RGD
Primary source: RGD:1306981
See related: Ensembl:ENSRNOG00000022309 AllianceGenome:RGD:1306981
Gene type: protein coding
RefSeq status: INFERRED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1306981
Summary: Predicted to be involved in craniofacial suture morphogenesis. Predicted to act upstream of or within cell-matrix adhesion. Predicted to be located in basement membrane. Predicted to be active in collagen-containing extracellular matrix. Biomarker of congenital diaphragmatic hernia. Human ortholog(s) of this gene implicated in congenital diaphragmatic hernia. Orthologous to human FREM1 (FRAS1 related extracellular matrix 1). [provided by Alliance of Genome Resources, Apr 2025]
Expression: Biased expression in Kidney (RPKM 165.7), Lung (RPKM 114.5) and 8 other tissues See more
Orthologs: all
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Genomic context

Location:: 5q31

Exon count:: 37

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (102367201..102515464, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (97321266..97469523, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (101018009..101166794, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Decreased expression of FREM1 in the nitrofen-induced congenital diaphragmatic hernia model may disturb the formation of the diaphragmatic mesenchyme, thus contributing to the development of diaphragmatic defects.
Title: Gene Expression of FRAS1-Related Extracellular Matrix 1 Is Decreased in Nitrofen-Induced Congenital Diaphragmatic Hernia.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in cell communication	IEA Inferred from Electronic Annotation more info
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in craniofacial suture morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in craniofacial suture morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in epithelial structure maintenance	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in basement membrane	IEA Inferred from Electronic Annotation more info
located_in basement membrane	ISO Inferred from Sequence Orthology more info
located_in cell periphery	IEA Inferred from Electronic Annotation more info
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: FRAS1-related extracellular matrix protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001411535.1 → NP_001398464.1 FRAS1-related extracellular matrix protein 1 precursor

Status: INFERRED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

A0A0G2KB00, A0ABK0LQE0

Related

ENSRNOP00000075592.3, ENSRNOT00000078862.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

102367201..102515464 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039109508.2 → XP_038965436.1 FRAS1-related extracellular matrix protein 1 isoform X1

Conserved Domains (1) summary

pfam16184
Location:402 → 508

Cadherin_3; Cadherin-like

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001191757.1: Suppressed sequence

Description

NM_001191757.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.