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Hspb7 heat shock protein family, member 7 (cardiovascular) [ Mus musculus (house mouse) ]

Gene ID: 29818, updated on 26-Sep-2022

Summary

Official Symbol
Hspb7provided by MGI
Official Full Name
heat shock protein family, member 7 (cardiovascular)provided by MGI
Primary source
MGI:MGI:1352494
See related
Ensembl:ENSMUSG00000006221 AllianceGenome:MGI:1352494
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
27kDa; cvHsp; Hsp25-2
Summary
Enables filamin binding activity. Predicted to be involved in response to heat. Located in actin cytoskeleton. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human HSPB7 (heat shock protein family B (small) member 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in heart adult (RPKM 366.5) and stomach adult (RPKM 18.0) See more
Orthologs
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Genomic context

See Hspb7 in Genome Data Viewer
Location:
4; 4 D3
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (141148090..141152621)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (141420779..141425310)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34693 Neighboring gene chloride channel, voltage-sensitive Kb Neighboring gene steroid receptor associated and regulated protein Neighboring gene predicted gene, 42337 Neighboring gene zinc finger and BTB domain containing 17

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Homology

Clone Names

  • MGC107591

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables filamin binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in heart development IEA
Inferred from Electronic Annotation
more info
 
involved_in response to heat ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in actin cytoskeleton IPI
Inferred from Physical Interaction
more info
PubMed 
located_in aggresome ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
heat shock protein beta-7
Names
cardiovascular heat shock protein
heat shock 27kDa protein family, member 7 (cardiovascular)
heat shock protein 25 kDa 2 (cardiovascular)
protein p19/6.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013868.4NP_038896.2  heat shock protein beta-7

    See identical proteins and their annotated locations for NP_038896.2

    Status: PROVISIONAL

    Source sequence(s)
    AL670285
    Consensus CDS
    CCDS18873.1
    UniProtKB/Swiss-Prot
    P35385, Q9QUS2
    Related
    ENSMUSP00000099544.5, ENSMUST00000102486.5
    Conserved Domains (1) summary
    cd06479
    Location:72152
    ACD_HspB7_like; Alpha crystallin domain (ACD) found in mammalian small heat shock protein (sHsp) HspB7, also known as cardiovascular small heat shock protein (cvHsp), and similar proteins. sHsps are molecular chaperones that suppress protein aggregation and protect ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    141148090..141152621
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)