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Frmd3 FERM domain containing 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 298141, updated on 10-Feb-2026
Official Symbol
Frmd3provided by RGD
Official Full Name
FERM domain containing 3provided by RGD
Primary source
RGD:1304802
See related
Ensembl:ENSRNOG00000006503 AllianceGenome:RGD:1304802
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable cytoskeletal protein binding activity. Predicted to be involved in actomyosin structure organization. Predicted to be located in membrane. Predicted to be active in cytoskeleton. Orthologous to human FRMD3 (FERM domain containing 3). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Brain (RPKM 39.3), Muscle (RPKM 11.4) and 4 other tissues See more
Orthologs
all
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See Frmd3 in Genome Data Viewer
Location:
5q31
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (92810989..93077326)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (87764755..88031091)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (90040495..90282327, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2310002L09 like Neighboring gene dnaJ homolog subfamily B member 1 pseudogene Neighboring gene protein disulfide-isomerase A5 pseudogene Neighboring gene COMM domain-containing protein 2 pseudogene Neighboring gene developmental pluripotency-associated 3, pseudogene 2 Neighboring gene lysine demethylase 4C Neighboring gene protein kinase C iota type-like

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cytoskeletal protein binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actomyosin structure organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
FERM domain-containing protein 3

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001415819.2 → NP_001402748.1  FERM domain-containing protein 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A8I5ZT99, A6J815
    Related
    ENSRNOP00000081802.1, ENSRNOT00000099661.2

  2. NM_001415820.1 → NP_001402749.1  FERM domain-containing protein 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A8I6AMS8, A6J815
    Related
    ENSRNOP00000095070.1, ENSRNOT00000100906.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    92810989..93077326
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039109494.2 → XP_038965422.1  FERM domain-containing protein 3 isoform X1

    UniProtKB/TrEMBL
    A6J815
    Conserved Domains (3) summary
    smart00295
    Location:1 → 143
    B41; Band 4.1 homologues
    pfam08736
    Location:241 → 283
    FA; FERM adjacent (FA)
    cl17171
    Location:124 → 227
    PH-like; Pleckstrin homology-like domain

  2. XM_063287360.1 → XP_063143430.1  FERM domain-containing protein 3 isoform X2

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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