Mup4l1 major urinary protein 4 like 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mup4l1provided by RGD
Official Full Name: major urinary protein 4 like 1provided by RGD
Primary source: RGD:1566134
See related: Ensembl:ENSRNOG00000083187 AllianceGenome:RGD:1566134
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mup; Mup4l2; RGD1566134
Summary: Predicted to enable insulin receptor activity and pheromone binding activity. Predicted to be involved in several processes, including locomotor rhythm; negative regulation of insulin secretion involved in cellular response to glucose stimulus; and regulation of primary metabolic process. Located in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]
Expression: Restricted expression toward (RPKM 19928.7) See more
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Genomic context

Location:: 5q24

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (80223093..80226566, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (75221340..75224797, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (77430657..77433866, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Methyl isobutyl ketone exerts nephrotoxic effects through a protein droplet alpha2u nephropathy-mediated mode of action.
Title: Methyl isobutyl ketone exposure-related increases in specific measures of α2u-globulin (α2u) nephropathy in male rats along with in vitro evidence of reversible protein binding.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables insulin receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables pheromone binding	ISS Inferred from Sequence or Structural Similarity more info
enables small molecule binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in aerobic respiration	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to lipid	ISS Inferred from Sequence or Structural Similarity more info
involved_in energy reserve metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in glucose homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in heat generation	ISS Inferred from Sequence or Structural Similarity more info
involved_in insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in locomotor rhythm	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrion organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of gluconeogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of lipid biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of lipid storage	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of glucose metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of lipid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: major urinary protein

Names: allergen Rat n I; allergen n I; alpha(2)-euglobulin; alpha-2u globulin PGCL1; alpha-2u globulin PGCL2; alpha-2u-globulin; alpha-2u-globulin (L type); major urinary protein 4 like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003409.2 → NP_001003409.2 major urinary protein precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

P02761, Q54AE7

UniProtKB/TrEMBL

A6KUS2, Q9JJI4

Related

ENSRNOP00000067914.3, ENSRNOT00000076791.4
NM_203512.3 → NP_988843.3 major urinary protein precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

P02761, Q54AE7

UniProtKB/TrEMBL

A6KUS2, Q9JJI4

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

80223093..80226566 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039109479.2 → XP_038965407.1 major urinary protein isoform X1

UniProtKB/Swiss-Prot

P02761, Q54AE7

UniProtKB/TrEMBL

A6KUS2, Q9JJI4

Conserved Domains (1) summary

cd19428
Location:24 → 181

lipocalin_MUP-like; major urinary proteins (MUPs) and similar proteins
XM_039109481.2 → XP_038965409.1 major urinary protein isoform X1

UniProtKB/Swiss-Prot

P02761, Q54AE7

UniProtKB/TrEMBL

A6KUS2, Q9JJI4

Conserved Domains (1) summary

cd19428
Location:24 → 181

lipocalin_MUP-like; major urinary proteins (MUPs) and similar proteins
XM_039109483.2 → XP_038965411.1 major urinary protein isoform X2

Conserved Domains (1) summary

cl10502
Location:15 → 119

lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family