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REPIN1 replication initiator 1 [ Homo sapiens (human) ]

Gene ID: 29803, updated on 5-Apr-2020

Summary

Official Symbol
REPIN1provided by HGNC
Official Full Name
replication initiator 1provided by HGNC
Primary source
HGNC:HGNC:17922
See related
Ensembl:ENSG00000214022
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AP4; RIP60; ZNF464; Zfp464
Expression
Ubiquitous expression in colon (RPKM 20.6), spleen (RPKM 16.1) and 25 other tissues See more
Orthologs

Genomic context

See REPIN1 in Genome Data Viewer
Location:
7q36.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (150368096..150374044)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (150065361..150071133)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986858 Neighboring gene retinoic acid receptor responder 2 Neighboring gene REPIN1 antisense RNA 1 Neighboring gene ZNF775 antisense RNA 1 Neighboring gene zinc finger protein 775 Neighboring gene uncharacterized LOC107986859

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of replication initiator 1 (REPIN1) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding HDA PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
DNA replication IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nuclear origin of replication recognition complex TAS
Traceable Author Statement
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
replication initiator 1
Names
60 kDa origin-specific DNA-binding protein
60 kDa replication initiation region protein
ATT-binding protein
DHFR oribeta-binding protein RIP60
H_DJ0584D14.12
replication initiation region protein (60kD)
zinc finger protein 464 (RIP60)
zinc finger protein AP4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099695.2NP_001093165.1  replication initiator 1 isoform 3

    See identical proteins and their annotated locations for NP_001093165.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate segment, compared to variant 1, that results in the use of an upstream start codon. The predicted protein (isoform 3) has a distinct N-terminus when it is compared to isoform 1. The biological validity of isoform 3 needs to be experimentally verified.
    Source sequence(s)
    AL046625, BC000363, CN386958
    Consensus CDS
    CCDS47745.1
    UniProtKB/Swiss-Prot
    Q9BWE0
    Related
    ENSP00000417291.2, ENST00000489432.6
    Conserved Domains (2) summary
    COG5048
    Location:290597
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:518538
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. NM_001099696.2NP_001093166.1  replication initiator 1 isoform 1

    See identical proteins and their annotated locations for NP_001093166.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AC005586, BC000363, CA449524
    Consensus CDS
    CCDS43677.1
    UniProtKB/Swiss-Prot
    Q9BWE0
    UniProtKB/TrEMBL
    A0A090N8H1
    Related
    ENSP00000407714.1, ENST00000444957.3
    Conserved Domains (2) summary
    COG5048
    Location:233540
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:461481
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. NM_001362745.2NP_001349674.1  replication initiator 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC005586, BC000363, CN386958
    Consensus CDS
    CCDS47745.1
    Conserved Domains (2) summary
    COG5048
    Location:290597
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:518538
    ZF_C2H2; C2H2 Zn finger [structural motif]
  4. NM_001362746.2NP_001349675.1  replication initiator 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC005586, AK292670, BC000363, BX443182, DB158657
    Consensus CDS
    CCDS43677.1
    Conserved Domains (2) summary
    COG5048
    Location:233540
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:461481
    ZF_C2H2; C2H2 Zn finger [structural motif]
  5. NM_001362747.2NP_001349676.1  replication initiator 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    BC000363, CD675150, CX166683
    Consensus CDS
    CCDS43677.1
    Related
    ENSP00000388287.2, ENST00000425389.2
    Conserved Domains (2) summary
    COG5048
    Location:233540
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:461481
    ZF_C2H2; C2H2 Zn finger [structural motif]
  6. NM_013400.3NP_037532.2  replication initiator 1 isoform 1

    See identical proteins and their annotated locations for NP_037532.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AL046625, BC000363, CA449524, CX166683
    Consensus CDS
    CCDS43677.1
    UniProtKB/Swiss-Prot
    Q9BWE0
    UniProtKB/TrEMBL
    A0A090N8H1
    Related
    ENSP00000380451.2, ENST00000397281.6
    Conserved Domains (2) summary
    COG5048
    Location:233540
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:461481
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    150368096..150374044
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006715949.3XP_006716012.1  replication initiator 1 isoform X1

    See identical proteins and their annotated locations for XP_006716012.1

    UniProtKB/Swiss-Prot
    Q9BWE0
    Conserved Domains (2) summary
    COG5048
    Location:290597
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:518538
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. XM_006715952.2XP_006716015.1  replication initiator 1 isoform X3

    See identical proteins and their annotated locations for XP_006716015.1

    UniProtKB/Swiss-Prot
    Q9BWE0
    UniProtKB/TrEMBL
    A0A090N8H1
    Conserved Domains (2) summary
    COG5048
    Location:233540
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:461481
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. XM_017012082.1XP_016867571.1  replication initiator 1 isoform X3

    UniProtKB/Swiss-Prot
    Q9BWE0
    UniProtKB/TrEMBL
    A0A090N8H1
    Conserved Domains (2) summary
    COG5048
    Location:233540
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:461481
    ZF_C2H2; C2H2 Zn finger [structural motif]
  4. XM_006715951.2XP_006716014.1  replication initiator 1 isoform X2

    See identical proteins and their annotated locations for XP_006716014.1

    Conserved Domains (3) summary
    COG5048
    Location:289621
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:517537
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:529554
    zf-H2C2_2; Zinc-finger double domain
  5. XM_006715947.3XP_006716010.1  replication initiator 1 isoform X1

    See identical proteins and their annotated locations for XP_006716010.1

    UniProtKB/Swiss-Prot
    Q9BWE0
    Conserved Domains (2) summary
    COG5048
    Location:290597
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:518538
    ZF_C2H2; C2H2 Zn finger [structural motif]
  6. XM_006715950.3XP_006716013.1  replication initiator 1 isoform X2

    See identical proteins and their annotated locations for XP_006716013.1

    Conserved Domains (3) summary
    COG5048
    Location:289621
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:517537
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:529554
    zf-H2C2_2; Zinc-finger double domain
  7. XM_024446737.1XP_024302505.1  replication initiator 1 isoform X3

    Conserved Domains (2) summary
    COG5048
    Location:233540
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:461481
    ZF_C2H2; C2H2 Zn finger [structural motif]
  8. XM_024446738.1XP_024302506.1  replication initiator 1 isoform X3

    Conserved Domains (2) summary
    COG5048
    Location:233540
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:461481
    ZF_C2H2; C2H2 Zn finger [structural motif]
  9. XM_017012081.2XP_016867570.1  replication initiator 1 isoform X3

    UniProtKB/Swiss-Prot
    Q9BWE0
    UniProtKB/TrEMBL
    A0A090N8H1
    Conserved Domains (2) summary
    COG5048
    Location:233540
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:461481
    ZF_C2H2; C2H2 Zn finger [structural motif]

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_014374.3: Suppressed sequence

    Description
    NM_014374.3: This RefSeq was removed because currently there is insufficient support for the transcript.
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