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VPREB3 V-set pre-B cell surrogate light chain 3 [ Homo sapiens (human) ]

Gene ID: 29802, updated on 5-Mar-2024


Official Symbol
VPREB3provided by HGNC
Official Full Name
V-set pre-B cell surrogate light chain 3provided by HGNC
Primary source
See related
Ensembl:ENSG00000128218 IMGT/GENE-DB:VPREB3; MIM:605017; AllianceGenome:HGNC:12710
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
8HS20; N27C7-2
The protein encoded by this gene is the human ortholog of the mouse VpreB3 (8HS20) protein, is thought to be involved in B-cell maturation, and may play a role in assembly of the pre-B cell receptor (pre-BCR). While the role of this protein in B-cell development has not yet been elucidated, studies with the chicken ortholog of this protein have found that when overexpressed, this protein localizes to the endoplasmic reticulum. The mouse ortholog of this protein has been shown to associate with membrane mu heavy chains early in the course of pre-B cell receptor biosynthesis. Expression of this gene has been observed in some lymphomas. [provided by RefSeq, Apr 2015]
Biased expression in lymph node (RPKM 35.6), spleen (RPKM 23.3) and 5 other tissues See more
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Genomic context

See VPREB3 in Genome Data Viewer
22q11.23; 22q11
Exon count:
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (23752743..23754425, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (24199936..24201618, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (24094930..24096612, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124905088 Neighboring gene zinc finger protein 70 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:24087516-24088016 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:24088017-24088517 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:24093057-24093732 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18759 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:24095085-24095758 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:24096535-24097035 Neighboring gene chromosome 22 open reading frame 15 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:24107697-24108496 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:24108497-24109296 Neighboring gene uncharacterized LOC107985577 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 10

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018


GeneRIFs: Gene References Into Functions

What's a GeneRIF?


Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
involved_in immunoglobulin production IBA
Inferred from Biological aspect of Ancestor
more info
Component Evidence Code Pubs
located_in endoplasmic reticulum NAS
Non-traceable Author Statement
more info
located_in extracellular region TAS
Traceable Author Statement
more info
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info

General protein information

Preferred Names
pre-B lymphocyte protein 3
pre-B lymphocyte 3
pre-B lymphocyte gene 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013378.3NP_037510.1  pre-B lymphocyte protein 3 precursor

    See identical proteins and their annotated locations for NP_037510.1

    Status: REVIEWED

    Source sequence(s)
    AF163825, AY359000, BQ899182
    Consensus CDS
    B2R587, Q9UKI3
    ENSP00000248948.3, ENST00000248948.4
    Conserved Domains (1) summary
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly


  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    23752743..23754425 complement
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0


  1. NC_060946.1 Alternate T2T-CHM13v2.0

    24199936..24201618 complement
    GenBank, FASTA, Sequence Viewer (Graphics)