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ZDHHC8 zinc finger DHHC-type palmitoyltransferase 8 [ Homo sapiens (human) ]

Gene ID: 29801, updated on 11-Jun-2021

Summary

Official Symbol
ZDHHC8provided by HGNC
Official Full Name
zinc finger DHHC-type palmitoyltransferase 8provided by HGNC
Primary source
HGNC:HGNC:18474
See related
Ensembl:ENSG00000099904 MIM:608784
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DHHC8; ZNF378; ZDHHCL1
Summary
This gene encodes a four transmembrane protein that is a member of the zinc finger DHHC domain-containing protein family. The encoded protein may function as a palmitoyltransferase. Defects in this gene may be associated with a susceptibility to schizophrenia. Alternate splicing of this gene results in multiple transcript variants. A pseudogene of this gene is found on chromosome 22.[provided by RefSeq, May 2010]
Expression
Ubiquitous expression in fat (RPKM 6.8), spleen (RPKM 6.7) and 25 other tissues See more
Orthologs
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Genomic context

See ZDHHC8 in Genome Data Viewer
Location:
22q11.21
Exon count:
11
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (20131804..20148007)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (20119327..20135530)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene tRNA methyltransferase 2 homolog A Neighboring gene microRNA 6816 Neighboring gene RAN binding protein 1 Neighboring gene small nucleolar RNA, H/ACA box 77B Neighboring gene coiled-coil domain containing 188 Neighboring gene Sharpr-MPRA regulatory region 11686

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables palmitoyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein-cysteine S-palmitoyltransferase activity IC
Inferred by Curator
more info
PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
palmitoyltransferase ZDHHC8
Names
membrane-associated DHHC8 zinc finger protein
zinc finger DHHC-type containing 8
zinc finger protein 378
zinc finger, DHHC domain like containing 1
NP_001171953.1
NP_037505.1
XP_006724302.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021420.1 RefSeqGene

    Range
    4964..21167
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001185024.2NP_001171953.1  palmitoyltransferase ZDHHC8 isoform 1

    See identical proteins and their annotated locations for NP_001171953.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC006547, AK131238, AY894890
    Consensus CDS
    CCDS54502.1
    UniProtKB/Swiss-Prot
    Q9ULC8
    Related
    ENSP00000384716.3, ENST00000405930.3
    Conserved Domains (2) summary
    PHA03247
    Location:333771
    PHA03247; large tegument protein UL36; Provisional
    pfam01529
    Location:99224
    DHHC; DHHC palmitoyltransferase
  2. NM_013373.4NP_037505.1  palmitoyltransferase ZDHHC8 isoform 2

    See identical proteins and their annotated locations for NP_037505.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC006547, AY894890, BC053544
    Consensus CDS
    CCDS13776.1
    UniProtKB/Swiss-Prot
    Q9ULC8
    Related
    ENSP00000334490.7, ENST00000334554.12
    Conserved Domains (2) summary
    PHA03247
    Location:333754
    PHA03247; large tegument protein UL36; Provisional
    pfam01529
    Location:99224
    DHHC; DHHC palmitoyltransferase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    20131804..20148007
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006724239.2XP_006724302.1  palmitoyltransferase ZDHHC8 isoform X1

    See identical proteins and their annotated locations for XP_006724302.1

    UniProtKB/Swiss-Prot
    Q9ULC8
    Conserved Domains (2) summary
    PHA03247
    Location:333771
    PHA03247; large tegument protein UL36; Provisional
    pfam01529
    Location:99224
    DHHC; DHHC palmitoyltransferase
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