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ZDHHC1 zinc finger DHHC-type containing 1 [ Homo sapiens (human) ]

Gene ID: 29800, updated on 11-Jun-2021

Summary

Official Symbol
ZDHHC1provided by HGNC
Official Full Name
zinc finger DHHC-type containing 1provided by HGNC
Primary source
HGNC:HGNC:17916
See related
Ensembl:ENSG00000159714
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DHHC-1; ZNF377; C16orf1; HSU90653
Expression
Ubiquitous expression in ovary (RPKM 6.2), testis (RPKM 6.1) and 24 other tissues See more
Orthologs
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Genomic context

See ZDHHC1 in Genome Data Viewer
Location:
16q22.1
Exon count:
12
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (67394152..67416494, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (67428055..67450380, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 36 Neighboring gene RNA, U1 small nuclear 123, pseudogene Neighboring gene tubulin polymerization promoting protein family member 3 Neighboring gene hydroxysteroid 11-beta dehydrogenase 2 Neighboring gene ATPase H+ transporting V0 subunit d1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding NAS
Non-traceable Author Statement
more info
PubMed 
enables palmitoyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-cysteine S-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in antiviral innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-L-cysteine S-palmitoylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of defense response to virus by host IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein palmitoylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular exosome HDA PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
palmitoyltransferase ZDHHC1
Names
DHHC domain-containing cysteine-rich protein 1
probable palmitoyltransferase ZDHHC1
zinc finger DHHC domain-containing protein 1
zinc finger protein 377
zinc finger, DHHC domain containing 1
NP_001310556.1
NP_037436.1
XP_006721248.1
XP_011521362.1
XP_024306013.1
XP_024306014.1
XP_024306015.1
XP_024306016.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001323627.2NP_001310556.1  palmitoyltransferase ZDHHC1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC009061, BM724650, BX111231, HY054038, U90653
    UniProtKB/Swiss-Prot
    Q8WTX9
    Related
    ENSP00000459264.2, ENST00000565726.3
    Conserved Domains (1) summary
    pfam01529
    Location:129284
    zf-DHHC; DHHC palmitoyltransferase
  2. NM_013304.3NP_037436.1  palmitoyltransferase ZDHHC1 isoform 1

    See identical proteins and their annotated locations for NP_037436.1

    Status: VALIDATED

    Source sequence(s)
    AC009061, BC021908, CA432496, U90653
    Consensus CDS
    CCDS10836.1
    UniProtKB/Swiss-Prot
    Q8WTX9
    Related
    ENSP00000340299.2, ENST00000348579.6
    Conserved Domains (1) summary
    pfam01529
    Location:129284
    zf-DHHC; DHHC palmitoyltransferase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    67394152..67416494 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450247.1XP_024306015.1  palmitoyltransferase ZDHHC1 isoform X4

    Conserved Domains (1) summary
    pfam01529
    Location:129284
    zf-DHHC; DHHC palmitoyltransferase
  2. XM_024450248.1XP_024306016.1  palmitoyltransferase ZDHHC1 isoform X6

    Conserved Domains (1) summary
    pfam01529
    Location:129284
    zf-DHHC; DHHC palmitoyltransferase
  3. XM_024450246.1XP_024306014.1  palmitoyltransferase ZDHHC1 isoform X3

    Conserved Domains (2) summary
    pfam01529
    Location:129284
    zf-DHHC; DHHC palmitoyltransferase
    pfam03546
    Location:323469
    Treacle; Treacher Collins syndrome protein Treacle
  4. XM_006721185.2XP_006721248.1  palmitoyltransferase ZDHHC1 isoform X2

    Conserved Domains (1) summary
    pfam01529
    Location:129284
    zf-DHHC; DHHC palmitoyltransferase
  5. XM_024450245.1XP_024306013.1  palmitoyltransferase ZDHHC1 isoform X1

    Conserved Domains (1) summary
    pfam01529
    Location:129284
    zf-DHHC; DHHC palmitoyltransferase
  6. XM_011523060.1XP_011521362.1  palmitoyltransferase ZDHHC1 isoform X5

    Conserved Domains (1) summary
    pfam01529
    Location:44199
    zf-DHHC; DHHC palmitoyltransferase
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