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YPEL1 yippee like 1 [ Homo sapiens (human) ]

Gene ID: 29799, updated on 19-Dec-2019

Summary

Official Symbol
YPEL1provided by HGNC
Official Full Name
yippee like 1provided by HGNC
Primary source
HGNC:HGNC:12845
See related
Ensembl:ENSG00000100027 MIM:608082
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FKSG3
Summary
This gene is located in the region associated with DiGeorge syndrome on chromosome 22. The encoded protein localizes to the centrosome and nucleolus and may play a role in the regulation of cell division. [provided by RefSeq, Feb 2015]
Expression
Broad expression in testis (RPKM 12.9), brain (RPKM 4.5) and 25 other tissues See more
Orthologs

Genomic context

See YPEL1 in Genome Data Viewer
Location:
22q11.21-q11.22
Exon count:
5
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (21697536..21735794, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (22051825..22090071, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985532 Neighboring gene microRNA 130b Neighboring gene peptidylprolyl isomerase like 2 Neighboring gene RNA, 7SL, cytoplasmic 280, pseudogene Neighboring gene mitogen-activated protein kinase 1 Neighboring gene RNA, 5S ribosomal pseudogene 493 Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent 1F Neighboring gene PPM1F antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC64992

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein yippee-like 1
Names
DiGeorge syndrome-related protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013313.5NP_037445.1  protein yippee-like 1

    See identical proteins and their annotated locations for NP_037445.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the protein.
    Source sequence(s)
    AB098734, AW006162, AW161786, BC015229
    Consensus CDS
    CCDS13794.1
    UniProtKB/Swiss-Prot
    O60688
    Related
    ENSP00000342832.3, ENST00000339468.8
    Conserved Domains (1) summary
    cl13152
    Location:21110
    RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

RNA

  1. NR_130910.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses two alternate splice sites in internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AB098734, AW161786, BC015229, BC048303

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    21697536..21735794 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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