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UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X [ Homo sapiens (human) ]

Gene ID: 29796, updated on 17-Jun-2024

Summary

Official Symbol
UQCR10provided by HGNC
Official Full Name
ubiquinol-cytochrome c reductase, complex III subunit Xprovided by HGNC
Primary source
HGNC:HGNC:30863
See related
Ensembl:ENSG00000184076 MIM:610843; AllianceGenome:HGNC:30863
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
QCR9; UCRC; HSPC051; HSPC119; HSPC151; UCCR7.2
Summary
UCRC is a subunit of mitochondrial complex III (ubiquinol-cytochrome c reductase; EC 1.10.2.2), which forms the middle segment of the respiratory chain of the inner mitochondrial membrane (Schagger et al., 1995 [PubMed 8592474]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in heart (RPKM 65.5), colon (RPKM 45.4) and 25 other tissues See more
Orthologs
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Genomic context

See UQCR10 in Genome Data Viewer
Location:
22q12.2
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (29767369..29770413)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (30230748..30233792)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (30163358..30166402)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:30101159-30101822 Neighboring gene MPRA-validated peak4478 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:30117301-30118091 Neighboring gene CABP7 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13596 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:30133259-30134112 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:30143413-30144160 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:30144161-30144906 Neighboring gene calcium binding protein 7 Neighboring gene zinc finger matrin-type 5 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:30162231-30162880 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:30162881-30163530 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:30179115-30179288 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:30194678-30195178 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:30195179-30195679 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:30196571-30197566 Neighboring gene activating signal cointegrator 1 complex subunit 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18820 Neighboring gene Sharpr-MPRA regulatory region 3108 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18822 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13597 Neighboring gene Sharpr-MPRA regulatory region 2042 Neighboring gene RNA, U6 small nuclear 331, pseudogene Neighboring gene myotubularin related protein 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
cytochrome b-c1 complex subunit 9
Names
cytochrome C1, nonheme 7kDa protein
cytochrome c1 non-heme 7 kDa protein
ubiquinol-cytochrome c reductase complex (7.2 kD)
ubiquinol-cytochrome c reductase complex 7.2 kDa protein
ubiquinol-cytochrome c reductase, complex III subunit X, 7.2kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003684.2NP_001003684.1  cytochrome b-c1 complex subunit 9 isoform b

    See identical proteins and their annotated locations for NP_001003684.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant uses an alternate splice site at the 3' end of the first exon compared to variant 1, that causes a frameshift. The resulting isoform (b) is shorter and has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    BU935406, CA311834, CB999839, CD674029
    Consensus CDS
    CCDS46681.1
    UniProtKB/Swiss-Prot
    Q9UDW1
    Related
    ENSP00000384962.3, ENST00000401406.3
    Conserved Domains (1) summary
    pfam05365
    Location:1050
    UCR_UQCRX_QCR9; Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like
  2. NM_013387.4NP_037519.2  cytochrome b-c1 complex subunit 9 isoform a

    See identical proteins and their annotated locations for NP_037519.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer and predominant isoform (a).
    Source sequence(s)
    BI754905, CA311834, CB999839
    Consensus CDS
    CCDS46680.1
    UniProtKB/Swiss-Prot
    B5MCM5, Q9T2V6, Q9UDW1
    Related
    ENSP00000332887.6, ENST00000330029.6
    Conserved Domains (1) summary
    pfam05365
    Location:1060
    UCR_UQCRX_QCR9; Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    29767369..29770413
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    30230748..30233792
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)