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UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X [ Homo sapiens (human) ]

Gene ID: 29796, updated on 1-Jun-2020

Summary

Official Symbol
UQCR10provided by HGNC
Official Full Name
ubiquinol-cytochrome c reductase, complex III subunit Xprovided by HGNC
Primary source
HGNC:HGNC:30863
See related
Ensembl:ENSG00000184076 MIM:610843
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
QCR9; UCRC; HSPC051; HSPC119; HSPC151; UCCR7.2
Summary
UCRC is a subunit of mitochondrial complex III (ubiquinol-cytochrome c reductase; EC 1.10.2.2), which forms the middle segment of the respiratory chain of the inner mitochondrial membrane (Schagger et al., 1995 [PubMed 8592474]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in heart (RPKM 65.5), colon (RPKM 45.4) and 25 other tissues See more
Orthologs

Genomic context

See UQCR10 in Genome Data Viewer
Location:
22q12.2
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (29767369..29770413)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (30163358..30166402)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene ribulose-5-phosphate-3-epimerase pseudogene 4 Neighboring gene neurofibromin 2 Neighboring gene calcium binding protein 7 Neighboring gene zinc finger matrin-type 5 Neighboring gene activating signal cointegrator 1 complex subunit 2 Neighboring gene Sharpr-MPRA regulatory region 2042 Neighboring gene myotubularin related protein 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ubiquinol-cytochrome-c reductase activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
aerobic respiration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial electron transport, ubiquinol to cytochrome c IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial electron transport, ubiquinol to cytochrome c NAS
Non-traceable Author Statement
more info
PubMed 
mitochondrial electron transport, ubiquinol to cytochrome c TAS
Traceable Author Statement
more info
 
mitochondrial respiratory chain complex III assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrial respiratory chain complex III IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
cytochrome b-c1 complex subunit 9
Names
cytochrome C1, nonheme 7kDa protein
cytochrome c1 non-heme 7 kDa protein
ubiquinol-cytochrome c reductase complex (7.2 kD)
ubiquinol-cytochrome c reductase complex 7.2 kDa protein
ubiquinol-cytochrome c reductase, complex III subunit X, 7.2kDa

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003684.1NP_001003684.1  cytochrome b-c1 complex subunit 9 isoform b

    See identical proteins and their annotated locations for NP_001003684.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant uses an alternate splice site at the 3' end of the first exon compared to variant 1, that causes a frameshift. The resulting isoform (b) is shorter and has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    BU935406, CA311834, CB999839, CD674029
    Consensus CDS
    CCDS46681.1
    UniProtKB/Swiss-Prot
    Q9UDW1
    Related
    ENSP00000384962.3, ENST00000401406.3
    Conserved Domains (1) summary
    pfam05365
    Location:950
    UCR_UQCRX_QCR9; Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like
  2. NM_013387.4NP_037519.2  cytochrome b-c1 complex subunit 9 isoform a

    See identical proteins and their annotated locations for NP_037519.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer and predominant isoform (a).
    Source sequence(s)
    BI754905, CA311834, CB999839
    Consensus CDS
    CCDS46680.1
    UniProtKB/Swiss-Prot
    Q9UDW1
    Related
    ENSP00000332887.6, ENST00000330029.6
    Conserved Domains (1) summary
    pfam05365
    Location:960
    UCR_UQCRX_QCR9; Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    29767369..29770413
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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