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OLA1 Obg like ATPase 1 [ Homo sapiens (human) ]

Gene ID: 29789, updated on 16-May-2020

Summary

Official Symbol
OLA1provided by HGNC
Official Full Name
Obg like ATPase 1provided by HGNC
Primary source
HGNC:HGNC:28833
See related
Ensembl:ENSG00000138430 MIM:611175
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DOC45; GBP45; GTBP9; GTPBP9; PTD004
Summary
This gene encodes a member of the GTPase protein family. The encoded protein interacts with breast cancer-associated gene 1 (BRCA1) and BRCA1-associated RING domain protein (BARD1), and is involved in centrosome regulation. Overexpression of this gene has been observed in multiple types of cancer and may be associated with poor survival. Pseudogenes of this gene have been defined on chromosomes 17 and 22. [provided by RefSeq, Jun 2016]
Expression
Ubiquitous expression in brain (RPKM 15.5), thyroid (RPKM 14.3) and 25 other tissues See more
Orthologs

Genomic context

See OLA1 in Genome Data Viewer
Location:
2q31.1
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (174072447..174248532, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (174937175..175113365, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373746 Neighboring gene ribosomal protein SA pseudogene 24 Neighboring gene VISTA enhancer hs243 Neighboring gene VISTA enhancer hs244 Neighboring gene RNA, 7SL, cytoplasmic 65, pseudogene Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 39 Neighboring gene LRRC2 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag HIV-1 Gag is identified to have a physical interaction with Obg-like ATPase 1 (OLA1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
matrix gag HIV-1 MA interacts with OLA1 PubMed
gag HIV-1 MA is identified to have a physical interaction with Obg-like ATPase 1 (OLA1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp313H1942

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATPase activity IDA
Inferred from Direct Assay
more info
PubMed 
GTP binding IEA
Inferred from Electronic Annotation
more info
 
cadherin binding HDA PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ribosomal large subunit binding IEA
Inferred from Electronic Annotation
more info
 
ribosome binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
ATP metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
platelet degranulation TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
centrosome IDA
Inferred from Direct Assay
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
membrane HDA PubMed 
nucleolus IEA
Inferred from Electronic Annotation
more info
 
platelet alpha granule lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
obg-like ATPase 1
Names
DNA damage-regulated overexpressed in cancer 45 protein
GTP-binding protein 9 (putative)
GTP-binding protein PTD004
homologous yeast-44.2 protein
NP_001011708.1
NP_001315617.1
NP_037473.3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051001.1 RefSeqGene

    Range
    5139..181224
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001011708.3NP_001011708.1  obg-like ATPase 1 isoform 2

    See identical proteins and their annotated locations for NP_001011708.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in its 5' UTR and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AC016737, AK074710
    Consensus CDS
    CCDS42779.1
    UniProtKB/Swiss-Prot
    Q9NTK5
    Related
    ENSP00000340167.5, ENST00000344357.9
    Conserved Domains (1) summary
    cl26749
    Location:1232
    GTP1; Ribosome-binding ATPase YchF, GTP1/OBG family [Translation, ribosomal structure and biogenesis]
  2. NM_001328688.2NP_001315617.1  obg-like ATPase 1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AC016737, AK225112
    Conserved Domains (1) summary
    PTZ00258
    Location:1369
    PTZ00258; GTP-binding protein; Provisional
  3. NM_013341.5NP_037473.3  obg-like ATPase 1 isoform 1

    See identical proteins and their annotated locations for NP_037473.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC016737, BC012842
    Consensus CDS
    CCDS2255.1
    UniProtKB/Swiss-Prot
    Q9NTK5
    Related
    ENSP00000284719.3, ENST00000284719.8
    Conserved Domains (1) summary
    PTZ00258
    Location:1390
    PTZ00258; GTP-binding protein; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    174072447..174248532 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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