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CYP2S1 cytochrome P450 family 2 subfamily S member 1 [ Homo sapiens (human) ]

Gene ID: 29785, updated on 6-Sep-2017
Official Symbol
CYP2S1provided by HGNC
Official Full Name
cytochrome P450 family 2 subfamily S member 1provided by HGNC
Primary source
HGNC:HGNC:15654
See related
Ensembl:ENSG00000167600 MIM:611529; Vega:OTTHUMG00000182721
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CYPIIS1
Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens; however, the specific function of the human protein has not been determined. [provided by RefSeq, Jul 2008]
Orthologs
Location:
19q13.2
Exon count:
9
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 19 NC_000019.10 (41193207..41207539)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (41699115..41713444)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene cytochrome P450 family 2 subfamily T member 3, pseudogene Neighboring gene ribosomal protein L36 pseudogene 16 Neighboring gene AXL receptor tyrosine kinase Neighboring gene transfer RNA-Lys (TTT) 10-1 Neighboring gene heterogeneous nuclear ribonucleoprotein U like 1 Neighboring gene RNA, 7SL, cytoplasmic 34, pseudogene

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
arachidonic acid epoxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
aromatase activity IEA
Inferred from Electronic Annotation
more info
 
heme binding IEA
Inferred from Electronic Annotation
more info
 
iron ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
retinoic acid 4-hydroxylase activity TAS
Traceable Author Statement
more info
 
steroid hydroxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
epoxygenase P450 pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
organelle membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
cytochrome P450 2S1
Names
cytochrome P450, family 2, subfamily S, polypeptide 1
cytochrome P540, subfamily IIS, polypeptide 1
NP_085125.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007933.3 RefSeqGene

    Range
    4998..19330
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_030622.7NP_085125.1  cytochrome P450 2S1 precursor

    See identical proteins and their annotated locations for NP_085125.1

    Status: REVIEWED

    Source sequence(s)
    AY358603, BC033691, BP284240
    Consensus CDS
    CCDS12573.1
    UniProtKB/Swiss-Prot
    Q96SQ9
    Related
    ENSP00000308032.3, OTTHUMP00000269969, ENST00000310054.8, OTTHUMT00000463287
    Conserved Domains (1) summary
    pfam00067
    Location:49492
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p7 Primary Assembly

    Range
    41193207..41207539
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_935812.2 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018930.2 Alternate CHM1_1.1

    Range
    41698868..41713172
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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