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ABT1 activator of basal transcription 1 [ Homo sapiens (human) ]

Gene ID: 29777, updated on 7-Jun-2020

Summary

Official Symbol
ABT1provided by HGNC
Official Full Name
activator of basal transcription 1provided by HGNC
Primary source
HGNC:HGNC:17369
See related
Ensembl:ENSG00000146109 MIM:618750
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Esf2; hABT1
Summary
Basal transcription of genes by RNA polymerase II requires the interaction of TATA-binding protein (TBP) with the core region of class II promoters. Studies in mouse suggest that the protein encoded by this gene likely activates basal transcription from class II promoters by interaction with TBP and the class II promoter DNA. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 4.4), lymph node (RPKM 3.9) and 25 other tissues See more
Orthologs

Genomic context

See ABT1 in Genome Data Viewer
Location:
6p22.2
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (26596953..26600739)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (26597171..26600278)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr6.1185 Neighboring gene tRNA-Tyr (anticodon GTA) 6-1 Neighboring gene uncharacterized LOC105374989 Neighboring gene vomeronasal 1 receptor 14 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding HDA PubMed 
RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription coactivator activity TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus TAS
Traceable Author Statement
more info
PubMed 
transcription factor complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
activator of basal transcription 1
Names
TATA-binding protein-binding protein
basal transcriptional activator

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013375.4NP_037507.1  activator of basal transcription 1

    See identical proteins and their annotated locations for NP_037507.1

    Status: REVIEWED

    Source sequence(s)
    AL513548
    Consensus CDS
    CCDS4616.1
    UniProtKB/Swiss-Prot
    Q9ULW3
    UniProtKB/TrEMBL
    A0A024R029
    Related
    ENSP00000274849.1, ENST00000274849.3
    Conserved Domains (1) summary
    cd12263
    Location:46149
    RRM_ABT1_like; RNA recognition motif found in activator of basal transcription 1 (ABT1) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    26596953..26600739
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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