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PACSIN3 protein kinase C and casein kinase substrate in neurons 3 [ Homo sapiens (human) ]

Gene ID: 29763, updated on 9-Jun-2020

Summary

Official Symbol
PACSIN3provided by HGNC
Official Full Name
protein kinase C and casein kinase substrate in neurons 3provided by HGNC
Primary source
HGNC:HGNC:8572
See related
Ensembl:ENSG00000165912 MIM:606513
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SDPIII
Summary
This gene is a member of the protein kinase C and casein kinase substrate in neurons family. The encoded protein is involved in linking the actin cytoskeleton with vesicle formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Expression
Broad expression in heart (RPKM 38.4), adrenal (RPKM 19.1) and 17 other tissues See more
Orthologs

Genomic context

See PACSIN3 in Genome Data Viewer
Location:
11p11.2
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (47177521..47186446, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (47199073..47208010, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene chromosome 11 open reading frame 49 Neighboring gene uncharacterized LOC107984329 Neighboring gene ADP ribosylation factor GTPase activating protein 2 Neighboring gene microRNA 6745 Neighboring gene ribosomal protein S20 pseudogene 26 Neighboring gene damage specific DNA binding protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ17861

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium channel inhibitor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoskeletal protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoskeletal protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
lipid binding IDA
Inferred from Direct Assay
more info
PubMed 
phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endocytosis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of calcium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of endocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane tubulation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane tubulation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of membrane protein ectodomain proteolysis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular exosome HDA PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
protein kinase C and casein kinase substrate in neurons protein 3
Names
SH3 domain-containing protein 6511
syndapin III

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001184974.2NP_001171903.1  protein kinase C and casein kinase substrate in neurons protein 3

    See identical proteins and their annotated locations for NP_001171903.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC090589, AF149825, BC007914
    Consensus CDS
    CCDS31481.1
    UniProtKB/Swiss-Prot
    Q9UKS6
    Conserved Domains (2) summary
    cl12013
    Location:16273
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl17036
    Location:365420
    SH3; Src Homology 3 domain superfamily
  2. NM_001184975.1NP_001171904.1  protein kinase C and casein kinase substrate in neurons protein 3

    See identical proteins and their annotated locations for NP_001171904.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC090589, AK000577, BC007914
    Consensus CDS
    CCDS31481.1
    UniProtKB/Swiss-Prot
    Q9UKS6
    Related
    ENSP00000440945.1, ENST00000539589.5
    Conserved Domains (2) summary
    cl12013
    Location:16273
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl17036
    Location:365420
    SH3; Src Homology 3 domain superfamily
  3. NM_016223.5NP_057307.2  protein kinase C and casein kinase substrate in neurons protein 3

    See identical proteins and their annotated locations for NP_057307.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    BC007914, BC011889, BI601317
    Consensus CDS
    CCDS31481.1
    UniProtKB/Swiss-Prot
    Q9UKS6
    Related
    ENSP00000298838.6, ENST00000298838.11
    Conserved Domains (2) summary
    cl12013
    Location:16273
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl17036
    Location:365420
    SH3; Src Homology 3 domain superfamily

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    47177521..47186446 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_002957143.1 RNA Sequence

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