Clec4a2 C-type lectin domain family 4, member A2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Clec4a2provided by RGD
Official Full Name: C-type lectin domain family 4, member A2provided by RGD
Primary source: RGD:1359163
See related: Ensembl:ENSRNOG00000030012 AllianceGenome:RGD:1359163
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Dcir2
Summary: Predicted to enable carbohydrate binding activity and pattern recognition receptor activity. Predicted to be involved in antifungal innate immune response. Predicted to be active in external side of plasma membrane. Orthologous to human CLEC4A (C-type lectin domain family 4 member A). [provided by Alliance of Genome Resources, Apr 2025]
Expression: Biased expression in Spleen (RPKM 19.2), Lung (RPKM 12.1) and 7 other tissues See more
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Genomic context

Location:: 4q42

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (157934342..157993595)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (156262438..156321695)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (155793059..155867731, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables carbohydrate binding	IBA Inferred from Biological aspect of Ancestor more info
enables pattern recognition receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in antifungal innate immune response	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: C-type lectin domain family 4, member A2

Names: dendritic cell inhibitory receptor 2; immunoreceptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001005880.1 → NP_001005880.1 C-type lectin domain family 4, member A2

See identical proteins and their annotated locations for NP_001005880.1

Status: PROVISIONAL

Source sequence(s)

AY397670

UniProtKB/TrEMBL

Q2TUM0, Q5YIS1

Related

ENSRNOP00000048802.2, ENSRNOT00000051525.5

Conserved Domains (1) summary

cd03590
Location:107 → 229

CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)