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Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon [ Rattus norvegicus (Norway rat) ]

Gene ID: 29753, updated on 3-Jan-2019

Summary

Official Symbol
Ywhaeprovided by RGD
Official Full Name
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilonprovided by RGD
Primary source
RGD:62000
See related
Ensembl:ENSRNOG00000005290
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
14-3-3e
Summary
epsilon subunit of a 14-3-3 protein; mediates signal transduction via calcium/calmodulin-dependent protein kinase II and protein kinase C [RGD, Feb 2006]
Annotation information
Annotation category: partial on reference assembly
Expression
Biased expression in Brain (RPKM 1110.2), Muscle (RPKM 785.1) and 9 other tissues See more
Orthologs

Genomic context

See Ywhae in Genome Data Viewer
Location:
10q24
Exon count:
6
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (63884338..63921709)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 10 NC_005109.3 (64084793..64121811, complement)

Chromosome 10 - NC_005109.4Genomic Context describing neighboring genes Neighboring gene myosin 1C Neighboring gene CRK proto-oncogene, adaptor protein Neighboring gene double C2 domain beta Neighboring gene uncharacterized LOC102549294 Neighboring gene rabphilin 3A-like (without C2 domains) Neighboring gene uncharacterized LOC102549419

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
calcium channel regulator activity IEA
Inferred from Electronic Annotation
more info
 
calcium channel regulator activity ISO
Inferred from Sequence Orthology
more info
 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
histone deacetylase binding IEA
Inferred from Electronic Annotation
more info
 
histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
 
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
ion channel binding IEA
Inferred from Electronic Annotation
more info
 
ion channel binding ISO
Inferred from Sequence Orthology
more info
 
phosphoprotein binding ISO
Inferred from Sequence Orthology
more info
 
phosphoserine residue binding IEA
Inferred from Electronic Annotation
more info
 
phosphoserine residue binding ISO
Inferred from Sequence Orthology
more info
 
potassium channel regulator activity IEA
Inferred from Electronic Annotation
more info
 
potassium channel regulator activity ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IEA
Inferred from Electronic Annotation
more info
 
protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase C inhibitor activity TAS
Traceable Author Statement
more info
PubMed 
protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
scaffold protein binding IEA
Inferred from Electronic Annotation
more info
 
scaffold protein binding ISO
Inferred from Sequence Orthology
more info
 
ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
MAPK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to heat ISO
Inferred from Sequence Orthology
more info
 
cellular response to heat ISS
Inferred from Sequence or Structural Similarity
more info
 
cerebral cortex development IEA
Inferred from Electronic Annotation
more info
 
cerebral cortex development ISO
Inferred from Sequence Orthology
more info
 
hippocampus development IEA
Inferred from Electronic Annotation
more info
 
hippocampus development ISO
Inferred from Sequence Orthology
more info
 
negative regulation of calcium ion export across plasma membrane IEA
Inferred from Electronic Annotation
more info
 
negative regulation of calcium ion export across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
negative regulation of calcium ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of calcium ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of peptidyl-serine dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of peptidyl-serine dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
neuron migration IEA
Inferred from Electronic Annotation
more info
 
neuron migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein export from nucleus ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein export from nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
 
protein localization to nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
protein targeting IEA
Inferred from Electronic Annotation
more info
 
protein targeting ISO
Inferred from Sequence Orthology
more info
 
regulation of cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 
regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
regulation of membrane repolarization IEA
Inferred from Electronic Annotation
more info
 
regulation of membrane repolarization ISO
Inferred from Sequence Orthology
more info
 
regulation of postsynaptic membrane neurotransmitter receptor levels EXP
Inferred from Experiment
more info
PubMed 
regulation of postsynaptic membrane neurotransmitter receptor levels IDA
Inferred from Direct Assay
more info
PubMed 
regulation of potassium ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
regulation of potassium ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
axon IDA
Inferred from Direct Assay
more info
PubMed 
central region of growth cone IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
glutamatergic synapse EXP
Inferred from Experiment
more info
PubMed 
glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
kinesin complex IDA
Inferred from Direct Assay
more info
PubMed 
melanosome IEA
Inferred from Electronic Annotation
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with plasma membrane ISO
Inferred from Sequence Orthology
more info
 
synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
14-3-3 protein epsilon
Names
14-3-3 epsilon
MSF L
mitochondrial import stimulation factor (MSF) L subunit
mitochondrial import stimulation factor L subunit
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activatioprotein epsilon polypeptide

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031603.1NP_113791.1  14-3-3 protein epsilon

    See identical proteins and their annotated locations for NP_113791.1

    Status: PROVISIONAL

    Source sequence(s)
    U53882
    UniProtKB/Swiss-Prot
    P62260
    Related
    ENSRNOP00000007100.3, ENSRNOT00000007100.5
    Conserved Domains (1) summary
    cd10020
    Location:4233
    14-3-3_epsilon; 14-3-3 epsilon, an isoform of 14-3-3 protein

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005109.4 Reference Rnor_6.0 Primary Assembly

    Range
    63884338..63921709
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000078.1 Alternate Rn_Celera

    Range
    59610373..59647466
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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