Nampt nicotinamide phosphoribosyltransferase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Namptprovided by RGD
Official Full Name: nicotinamide phosphoribosyltransferaseprovided by RGD
Primary source: RGD:631365
See related: Ensembl:ENSRNOG00000009754 AllianceGenome:RGD:631365
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pbef; Pbef1
Summary: Enables several functions, including cytokine activity; identical protein binding activity; and nicotinamide phosphoribosyltransferase activity. Involved in several processes, including cellular response to amyloid-beta; microglial cell activation; and negative regulation of cellular senescence. Predicted to be located in cell junction; cytoplasm; and nuclear speck. Used to study middle cerebral artery infarction and transient cerebral ischemia. Biomarker of kidney failure; metabolic dysfunction-associated steatotic liver disease; periodontitis; and pulmonary hypertension. Human ortholog(s) of this gene implicated in transient cerebral ischemia. Orthologous to human NAMPT (nicotinamide phosphoribosyltransferase). [provided by Alliance of Genome Resources, Apr 2025]
Expression: Biased expression in Muscle (RPKM 673.5), Heart (RPKM 463.7) and 9 other tissues See more
Orthologs: all
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Genomic context

Location:: 6q16

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (55152756..55189547)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (49425316..49462109)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (52122085..52156473)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NAMPT mediates PDGF-induced pulmonary arterial smooth muscle cell proliferation by TLR4/NF-kappaB/PLK4 signaling pathway.
Title: NAMPT mediates PDGF-induced pulmonary arterial smooth muscle cell proliferation by TLR4/NF-κB/PLK4 signaling pathway.
Emodin inhibits NF-kappaB signaling pathway to protect obese asthmatic rats from pathological damage via Visfatin.
Title: Emodin inhibits NF-κB signaling pathway to protect obese asthmatic rats from pathological damage via Visfatin.
Metabolic Enzyme Triosephosphate Isomerase 1 and Nicotinamide Phosphoribosyltransferase, Two Independent Inflammatory Indicators in Rheumatoid Arthritis: Evidences From Collagen-Induced Arthritis and Clinical Samples.
Title: Metabolic Enzyme Triosephosphate Isomerase 1 and Nicotinamide Phosphoribosyltransferase, Two Independent Inflammatory Indicators in Rheumatoid Arthritis: Evidences From Collagen-Induced Arthritis and Clinical Samples.
Nampt promotes fibroblast extracellular matrix degradation in stress urinary incontinence by inhibiting autophagy.
Title: Nampt promotes fibroblast extracellular matrix degradation in stress urinary incontinence by inhibiting autophagy.
Small Extracellular Vesicles Derived from Adipocytes Attenuate Intervertebral Disc Degeneration in Rats by Rejuvenating Senescent Nucleus Pulposus Cells and Endplate Cells by Delivering Exogenous NAMPT.
Title: Small Extracellular Vesicles Derived from Adipocytes Attenuate Intervertebral Disc Degeneration in Rats by Rejuvenating Senescent Nucleus Pulposus Cells and Endplate Cells by Delivering Exogenous NAMPT.
Notoginsenoside R1 activates the NAMPT-NAD(+)-SIRT1 cascade to promote postischemic angiogenesis by modulating Notch signaling.
Title: Notoginsenoside R1 activates the NAMPT-NAD(+)-SIRT1 cascade to promote postischemic angiogenesis by modulating Notch signaling.
Visfatin Increases VEGF-dependent Angiogenesis of Endothelial Progenitor Cells during Osteoarthritis Progression.
Title: Visfatin Increases VEGF-dependent Angiogenesis of Endothelial Progenitor Cells during Osteoarthritis Progression.
de novo NAMPT synthesis in osteoblasts controls cell differentiation through osteoclast recruitment during the activation of bone remodeling.
Title: NAMPT expression in osteoblasts controls osteoclast recruitment in alveolar bone remodeling.
A Strong association was observed among fasting blood glucose, serum visfatin and trace elements levels of high fat diet and type 2 diabetes mellitus
Title: Potential role of peroxisome proliferator activated receptor gamma activation on serum visfatin and trace elements in high fat diet induced type 2 diabetes mellitus.
Our findings suggest that NAMPT inhibition may be a novel therapeutic approach for I/R-induced lung injury. The protective effects involve the suppression of multiple signal pathways.
Title: Targeting of nicotinamide phosphoribosyltransferase enzymatic activity ameliorates lung damage induced by ischemia/reperfusion in rats.

Submit: New GeneRIF Correction See all GeneRIFs (47)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cytokine activity	IDA Inferred from Direct Assay more info	PubMed
enables heterocyclic compound binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables nicotinamide phosphoribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables nicotinamide phosphoribosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables nicotinamide phosphoribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables nicotinamide phosphoribosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables nicotinamide phosphoribosyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables nucleotide binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in NAD+ biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in NAD+ biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within NAD+ biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in NAD+ biosynthetic process via the salvage pathway	ISO Inferred from Sequence Orthology more info
involved_in NADP+ biosynthetic process	ISO Inferred from Sequence Orthology more info
NOT involved_in adipose tissue development	ISO Inferred from Sequence Orthology more info
involved_in cellular response to amyloid-beta	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to ionizing radiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in circadian regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in circadian regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in circadian rhythm	IEP Inferred from Expression Pattern more info	PubMed
involved_in circadian rhythm	ISO Inferred from Sequence Orthology more info
involved_in female pregnancy	IEP Inferred from Expression Pattern more info	PubMed
involved_in inflammatory response	ISO Inferred from Sequence Orthology more info
NOT involved_in insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in microglial cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cellular senescence	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of lung blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to D-galactose	IEP Inferred from Expression Pattern more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: nicotinamide phosphoribosyltransferase

Names: NAmPRTase; pre-B-cell colony enhancing factor 1; pre-B-cell colony-enhancing factor 1 homolog; visfatin

NP_808789.1

EC 2.4.2.12

XP_038967818.1

EC 2.4.2.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_177928.3 → NP_808789.1 nicotinamide phosphoribosyltransferase

See identical proteins and their annotated locations for NP_808789.1

Status: PROVISIONAL

Source sequence(s)

BC085681

UniProtKB/Swiss-Prot

Q2VT47, Q80Z29

UniProtKB/TrEMBL

A0A0G2K0I3, A6HB68

Related

ENSRNOP00000013043.5, ENSRNOT00000013043.8

Conserved Domains (1) summary

cd01569
Location:12 → 428

PBEF_like; pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general, ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

55152756..55189547

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039111890.2 → XP_038967818.1 nicotinamide phosphoribosyltransferase isoform X1

UniProtKB/TrEMBL

A0A0G2K0I3

Related

ENSRNOP00000071458.1, ENSRNOT00000086432.3

Conserved Domains (1) summary

cd01569
Location:28 → 437

PBEF_like; pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general, ...