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GTF3C1 general transcription factor IIIC subunit 1 [ Homo sapiens (human) ]

Gene ID: 2975, updated on 7-Jun-2020

Summary

Official Symbol
GTF3C1provided by HGNC
Official Full Name
general transcription factor IIIC subunit 1provided by HGNC
Primary source
HGNC:HGNC:4664
See related
Ensembl:ENSG00000077235 MIM:603246
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TFIIIC; TFIIIC220; TFIIICalpha
Expression
Ubiquitous expression in thyroid (RPKM 19.5), prostate (RPKM 18.6) and 25 other tissues See more
Orthologs

Genomic context

See GTF3C1 in Genome Data Viewer
Location:
16p12.1
Exon count:
37
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (27460613..27549922, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (27471934..27561251, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene interleukin 4 receptor Neighboring gene interleukin 21 receptor Neighboring gene IL21R antisense RNA 1 Neighboring gene katanin interacting protein Neighboring gene uncharacterized LOC107984874 Neighboring gene uncharacterized LOC100128079

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the transcription by RNA polymerase III of co-transfected or endogenous cellular Alu-repeated sequences by activating transcription factor TFIIIC PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp686A111

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to DNA binding IC
Inferred by Curator
more info
PubMed 
RNA polymerase III type 1 promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase III type 2 promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
membrane HDA PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
 
transcription factor TFIIIC complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription factor TFIIIC complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
general transcription factor 3C polypeptide 1
Names
TF3C-alpha
TFIIIC 220 kDa subunit
TFIIIC box B-binding subunit
general transcription factor IIIC, polypeptide 1 (alpha subunit)
general transcription factor IIIC, polypeptide 1, alpha 220kDa
transcription factor IIIC 220 kDa subunit
transcription factor IIIC subunit alpha

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286242.2NP_001273171.1  general transcription factor 3C polypeptide 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC002303, AC025275, BC044857, BC137229
    Consensus CDS
    CCDS66988.1
    UniProtKB/Swiss-Prot
    Q12789
    Related
    ENSP00000455417.1, ENST00000561623.5
    Conserved Domains (1) summary
    pfam04182
    Location:174250
    B-block_TFIIIC; B-block binding subunit of TFIIIC
  2. NM_001520.4NP_001511.2  general transcription factor 3C polypeptide 1 isoform 1

    See identical proteins and their annotated locations for NP_001511.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC044857, BC137229, BP283960, CA414192
    Consensus CDS
    CCDS32414.1
    UniProtKB/Swiss-Prot
    Q12789
    Related
    ENSP00000348510.4, ENST00000356183.9
    Conserved Domains (2) summary
    pfam04182
    Location:174250
    B-block_TFIIIC; B-block binding subunit of TFIIIC
    cl22974
    Location:18811975
    HpaP; Type III secretion protein (HpaP)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    27460613..27549922 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017023188.2XP_016878677.1  general transcription factor 3C polypeptide 1 isoform X1

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