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GTF3A general transcription factor IIIA [ Homo sapiens (human) ]

Gene ID: 2971, updated on 22-Aug-2020

Summary

Official Symbol
GTF3Aprovided by HGNC
Official Full Name
general transcription factor IIIAprovided by HGNC
Primary source
HGNC:HGNC:4662
See related
Ensembl:ENSG00000122034 MIM:600860
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AP2; TFIIIA
Summary
The product of this gene is a zinc finger protein with nine Cis[2]-His[2] zinc finger domains. It functions as an RNA polymerase III transcription factor to induce transcription of the 5S rRNA genes. The protein binds to a 50 bp internal promoter in the 5S genes called the internal control region (ICR), and nucleates formation of a stable preinitiation complex. This complex recruits the TFIIIC and TFIIIB transcription factors and RNA polymerase III to form the complete transcription complex. The protein is thought to be translated using a non-AUG translation initiation site in mammals based on sequence analysis, protein homology, and the size of the purified protein. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in fat (RPKM 54.8), heart (RPKM 50.8) and 25 other tissues See more
Orthologs

Genomic context

See GTF3A in Genome Data Viewer
Location:
13q12.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (27424619..27435823)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (27998681..28009846)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370126 Neighboring gene RNY1 pseudogene 1 Neighboring gene mitochondrial translational initiation factor 3 Neighboring gene RNA, U6 small nuclear 63, pseudogene Neighboring gene ligand of numb-protein X 2 Neighboring gene RNA polymerase I and III subunit D

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
5S rRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
DNA binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
rRNA transcription TAS
Traceable Author Statement
more info
PubMed 
ribosomal large subunit biogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription by RNA polymerase III TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002097.3NP_002088.2  transcription factor IIIA

    See identical proteins and their annotated locations for NP_002088.2

    Status: REVIEWED

    Source sequence(s)
    AL137059, AW627732, BP254755, D32257, U20272
    Consensus CDS
    CCDS45019.1
    UniProtKB/Swiss-Prot
    Q92664
    Related
    ENSP00000370532.4, ENST00000381140.9
    Conserved Domains (2) summary
    COG5048
    Location:64187
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:4564
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    27424619..27435823
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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