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Snx10 sorting nexin 10 [ Rattus norvegicus (Norway rat) ]

Gene ID: 297096, updated on 5-Jan-2022

Summary

Official Symbol
Snx10provided by RGD
Official Full Name
sorting nexin 10provided by RGD
Primary source
RGD:1305782
See related
Ensembl:ENSRNOG00000011944
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable 1-phosphatidylinositol binding activity and ATPase binding activity. Predicted to be involved in several processes, including endosome organization; osteoclast differentiation; and protein localization to organelle. Predicted to act upstream of or within several processes, including bone mineralization involved in bone maturation; bone resorption; and cellular response to leukemia inhibitory factor. Predicted to be located in several cellular components, including apical cytoplasm; endoplasmic reticulum; and secretory granule. Predicted to be extrinsic component of endosome membrane. Predicted to colocalize with centrosome. Human ortholog(s) of this gene implicated in autosomal recessive osteopetrosis 8. Orthologous to human SNX10 (sorting nexin 10). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in Brain (RPKM 263.1), Lung (RPKM 101.8) and 9 other tissues See more
Orthologs
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Genomic context

See Snx10 in Genome Data Viewer
Location:
4q24
Exon count:
11
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (80612648..80677005)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (81311490..81375248)

Chromosome 4 - NC_051339.1Genomic Context describing neighboring genes Neighboring gene chromobox 3 Neighboring gene similar to Translocase of outer mitochondrial membrane 20 homolog Neighboring gene MICOS complex subunit MIC13-like Neighboring gene uncharacterized LOC120102272 Neighboring gene uncharacterized LOC120102273 Neighboring gene uncharacterized LOC120102274

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Homology

Clone Names

  • MGC109202

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 1-phosphatidylinositol binding ISO
Inferred from Sequence Orthology
more info
 
enables ATPase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within bone mineralization involved in bone maturation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within bone remodeling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within bone resorption ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to leukemia inhibitory factor ISO
Inferred from Sequence Orthology
more info
 
involved_in cilium assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in endosome organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within gastric acid secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to centrosome ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to cilium ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within ruffle assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within tooth eruption ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in apical cytoplasm ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in extrinsic component of endosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in secretory granule ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013085.1NP_001013103.1  sorting nexin-10

    See identical proteins and their annotated locations for NP_001013103.1

    Status: PROVISIONAL

    Source sequence(s)
    BC091290
    UniProtKB/TrEMBL
    Q5BJX4
    Conserved Domains (1) summary
    cd06898
    Location:12109
    PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051339.1 Reference mRatBN7.2 Primary Assembly

    Range
    80612648..80677005
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039107307.1XP_038963235.1  sorting nexin-10 isoform X1

    Related
    ENSRNOP00000016265.5, ENSRNOT00000016265.6
    Conserved Domains (1) summary
    cd06898
    Location:12109
    PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10
  2. XM_006236486.4XP_006236548.1  sorting nexin-10 isoform X1

    See identical proteins and their annotated locations for XP_006236548.1

    UniProtKB/TrEMBL
    Q5BJX4
    Conserved Domains (1) summary
    cd06898
    Location:12109
    PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10
  3. XM_006236490.2XP_006236552.1  sorting nexin-10 isoform X1

    See identical proteins and their annotated locations for XP_006236552.1

    UniProtKB/TrEMBL
    Q5BJX4
    Conserved Domains (1) summary
    cd06898
    Location:12109
    PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10
  4. XM_006236489.4XP_006236551.1  sorting nexin-10 isoform X1

    See identical proteins and their annotated locations for XP_006236551.1

    UniProtKB/TrEMBL
    Q5BJX4
    Conserved Domains (1) summary
    cd06898
    Location:12109
    PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10
  5. XM_006236488.4XP_006236550.1  sorting nexin-10 isoform X1

    See identical proteins and their annotated locations for XP_006236550.1

    UniProtKB/TrEMBL
    Q5BJX4
    Conserved Domains (1) summary
    cd06898
    Location:12109
    PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10
  6. XM_039107308.1XP_038963236.1  sorting nexin-10 isoform X2

    Conserved Domains (1) summary
    cl02563
    Location:169
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
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