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Gabra1 gamma-aminobutyric acid type A receptor alpha1 subunit [ Rattus norvegicus (Norway rat) ]

Gene ID: 29705, updated on 12-Aug-2018
Official Symbol
Gabra1provided by RGD
Official Full Name
gamma-aminobutyric acid type A receptor alpha1 subunitprovided by RGD
Primary source
RGD:61855
See related
Ensembl:ENSRNOG00000003512
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
subunit of GABAA receptors, which bind benzodiazepines and act as inhibitory ion channels in the brain [RGD, Feb 2006]
Expression
Restricted expression toward (RPKM 742.3) See more
Orthologs
See Gabra1 in Genome Data Viewer
Location:
10q21
Exon count:
14
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (27310718..27371802, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 10 NC_005109.3 (27154354..27209873, complement)

Chromosome 10 - NC_005109.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103690411 Neighboring gene uncharacterized LOC102548672 Neighboring gene gamma-aminobutyric acid type A receptor gamma 2 subunit Neighboring gene uncharacterized LOC108352216 Neighboring gene uncharacterized LOC102547488

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
contributes_to GABA receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
CONTRIBUTES_TO GABA-A receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GABA-A receptor activity TAS
Traceable Author Statement
more info
PubMed 
GABA-gated chloride ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GABA-gated chloride ion channel activity IEA
Inferred from Electronic Annotation
more info
 
GABA-gated chloride ion channel activity ISO
Inferred from Sequence Orthology
more info
 
CONTRIBUTES_TO benzodiazepine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
benzodiazepine receptor activity TAS
Traceable Author Statement
more info
PubMed 
chloride channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
drug binding IDA
Inferred from Direct Assay
more info
PubMed 
CONTRIBUTES_TO extracellular ligand-gated ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inhibitory extracellular ligand-gated ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inhibitory extracellular ligand-gated ion channel activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential IEA
Inferred from Electronic Annotation
more info
 
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cellular response to histamine IDA
Inferred from Direct Assay
more info
PubMed 
chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
chloride transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chloride transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
chloride transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
chloride transport TAS
Traceable Author Statement
more info
PubMed 
gamma-aminobutyric acid signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
gamma-aminobutyric acid signaling pathway TAS
Traceable Author Statement
more info
PubMed 
ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
nervous system process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of postsynaptic membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of postsynaptic membrane potential IEA
Inferred from Electronic Annotation
more info
 
regulation of postsynaptic membrane potential ISO
Inferred from Sequence Orthology
more info
 
signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
synaptic transmission, GABAergic IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
synaptic transmission, GABAergic IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
GABA receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
GABA-A receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GABA-A receptor complex ISO
Inferred from Sequence Orthology
more info
 
GABA-ergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
cell junction IEA
Inferred from Electronic Annotation
more info
 
chloride channel complex IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
dendrite membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of postsynaptic specialization membrane IDA
Inferred from Direct Assay
more info
PubMed 
neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
postsynapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Preferred Names
gamma-aminobutyric acid receptor subunit alpha-1
Names
GABA(A) receptor subunit alpha-1
gamma-aminobutyric acid A receptor, alpha 1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_183326.2NP_899155.1  gamma-aminobutyric acid receptor subunit alpha-1 precursor

    See identical proteins and their annotated locations for NP_899155.1

    Status: PROVISIONAL

    Source sequence(s)
    BC100061
    UniProtKB/Swiss-Prot
    P62813
    Related
    ENSRNOP00000004725.5, ENSRNOT00000004725.7
    Conserved Domains (1) summary
    cl27321
    Location:7441
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005109.4 Reference Rnor_6.0 Primary Assembly

    Range
    27310718..27371802 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017597178.1XP_017452667.1  gamma-aminobutyric acid receptor subunit alpha-1 isoform X1

  2. XM_017597179.1XP_017452668.1  gamma-aminobutyric acid receptor subunit alpha-1 isoform X2

    UniProtKB/Swiss-Prot
    P62813
    Conserved Domains (1) summary
    cl27321
    Location:7441
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
  3. XM_006246124.3XP_006246186.1  gamma-aminobutyric acid receptor subunit alpha-1 isoform X2

    See identical proteins and their annotated locations for XP_006246186.1

    UniProtKB/Swiss-Prot
    P62813
    Conserved Domains (1) summary
    cl27321
    Location:7441
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
  4. XM_006246123.3XP_006246185.1  gamma-aminobutyric acid receptor subunit alpha-1 isoform X2

    See identical proteins and their annotated locations for XP_006246185.1

    UniProtKB/Swiss-Prot
    P62813
    Conserved Domains (1) summary
    cl27321
    Location:7441
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain

Alternate Rn_Celera

Genomic

  1. AC_000078.1 Alternate Rn_Celera

    Range
    26109305..26164180 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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