Format

Send to:

Choose Destination

Prkar2a protein kinase cAMP-dependent type II regulatory subunit alpha [ Rattus norvegicus (Norway rat) ]

Gene ID: 29699, updated on 10-Oct-2019

Summary

Official Symbol
Prkar2aprovided by RGD
Official Full Name
protein kinase cAMP-dependent type II regulatory subunit alphaprovided by RGD
Primary source
RGD:3393
See related
Ensembl:ENSRNOG00000020284
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
regulatory subunit for cAMP dependent protein kinase [RGD, Feb 2006]
Expression
Biased expression in Muscle (RPKM 500.4), Kidney (RPKM 256.3) and 9 other tissues See more
Orthologs

Genomic context

See Prkar2a in Genome Data Viewer
Location:
8q32
Exon count:
13
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (117486085..117548768)
106 current Rn_Celera (GCF_000002265.2) 8 AC_000076.1 (108691132..108750351)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 8 NC_005107.3 (116830841..116893276)

Chromosome 8 - NC_005107.4Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 member 20 Neighboring gene similar to ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G Neighboring gene inositol hexakisphosphate kinase 2 Neighboring gene NCK interacting protein with SH3 domain

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
3',5'-cyclic-GMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
beta-2 adrenergic receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
cAMP binding IDA
Inferred from Direct Assay
more info
PubMed 
cAMP binding IEA
Inferred from Electronic Annotation
more info
 
cAMP-dependent protein kinase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
cAMP-dependent protein kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
PubMed 
cAMP-dependent protein kinase regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
cAMP-dependent protein kinase regulator activity ISO
Inferred from Sequence Orthology
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IDA
Inferred from Direct Assay
more info
PubMed 
protein domain specific binding IEA
Inferred from Electronic Annotation
more info
 
protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding ISO
Inferred from Sequence Orthology
more info
PubMed 
protein kinase A catalytic subunit binding IC
Inferred by Curator
more info
PubMed 
protein kinase A catalytic subunit binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase A catalytic subunit binding ISO
Inferred from Sequence Orthology
more info
PubMed 
protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
small molecule binding IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
T-tubule IDA
Inferred from Direct Assay
more info
PubMed 
axoneme IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with axoneme ISO
Inferred from Sequence Orthology
more info
PubMed 
cAMP-dependent protein kinase complex IDA
Inferred from Direct Assay
more info
PubMed 
cAMP-dependent protein kinase complex IEA
Inferred from Electronic Annotation
more info
 
cAMP-dependent protein kinase complex ISO
Inferred from Sequence Orthology
more info
PubMed 
centrosome IEA
Inferred from Electronic Annotation
more info
 
centrosome ISO
Inferred from Sequence Orthology
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
germinal vesicle ISO
Inferred from Sequence Orthology
more info
PubMed 
glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
PubMed 
nucleotide-activated protein kinase complex IEA
Inferred from Electronic Annotation
more info
 
nucleotide-activated protein kinase complex ISO
Inferred from Sequence Orthology
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
plasma membrane raft IEA
Inferred from Electronic Annotation
more info
 
plasma membrane raft ISO
Inferred from Sequence Orthology
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex ISO
Inferred from Sequence Orthology
more info
PubMed 
synapse ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
cAMP-dependent protein kinase type II-alpha regulatory subunit
Names
protein kinase cAMP-dependent type 2 regulatory subunit alpha
protein kinase, cAMP dependent regulatory, type II alpha
protein kinase, cAMP-dependent, regulatory subunit type II alpha
protein kinase, cAMP-dependent, regulatory, type 2, alpha
NP_062137.1
XP_006243775.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019264.2NP_062137.1  cAMP-dependent protein kinase type II-alpha regulatory subunit

    See identical proteins and their annotated locations for NP_062137.1

    Status: PROVISIONAL

    Source sequence(s)
    AF533978
    UniProtKB/Swiss-Prot
    P12368
    Related
    ENSRNOP00000027552.2, ENSRNOT00000027552.3
    Conserved Domains (3) summary
    cd12103
    Location:444
    DD_RIIalpha_PKA; Dimerization/Docking domain of the Type II alpha Regulatory subunit of cAMP-dependent protein kinase
    COG0664
    Location:252368
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:258379
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005107.4 Reference Rnor_6.0 Primary Assembly

    Range
    117486085..117548768
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006243713.3XP_006243775.1  cAMP-dependent protein kinase type II-alpha regulatory subunit isoform X1

    Conserved Domains (2) summary
    COG0664
    Location:199315
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:205326
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

Alternate Rn_Celera

Genomic

  1. AC_000076.1 Alternate Rn_Celera

    Range
    108691132..108750351
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center