Format

Send to:

Choose Destination

Akr1b10 aldo-keto reductase family 1 member B10 [ Rattus norvegicus (Norway rat) ]

Gene ID: 296972, updated on 25-Jan-2022

Summary

Symbol
Akr1b10provided by RGD
Full Name
aldo-keto reductase family 1 member B10provided by RGD
Primary source
RGD:1308277
See related
Ensembl:ENSRNOG00000009734 AllianceGenome:RGD:1308277
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables NADP binding activity; alcohol dehydrogenase (NADP+) activity; and retinal binding activity. Involved in polyol metabolic process; retinal metabolic process; and retinol metabolic process. Located in cytosol. Orthologous to human AKR1B10 (aldo-keto reductase family 1 member B10). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in Adrenal (RPKM 1546.2), Kidney (RPKM 276.7) and 3 other tissues See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Akr1b10 in Genome Data Viewer
Location:
4q22
Exon count:
12
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (63038459..63060336)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (61813265..61830371)

Chromosome 4 - NC_051339.1Genomic Context describing neighboring genes Neighboring gene aldo-keto reductase family 1 member B Neighboring gene aldo-keto reductase family 1, member B8 Neighboring gene myosin light polypeptide 6-like Neighboring gene aldo-keto reductase family 1, member B7 Neighboring gene bisphosphoglycerate mutase

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Pathways from PubChem

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables D-threo-aldose 1-dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 
enables NADP+ binding IDA
Inferred from Direct Assay
more info
PubMed 
enables NADP-retinol dehydrogenase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables NADP-retinol dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
enables NADPH binding IDA
Inferred from Direct Assay
more info
PubMed 
enables alcohol dehydrogenase (NADP+) activity ISO
Inferred from Sequence Orthology
more info
 
enables alditol:NADP+ 1-oxidoreductase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables geranylgeranyl reductase activity ISO
Inferred from Sequence Orthology
more info
 
enables indanol dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
enables retinal binding IDA
Inferred from Direct Assay
more info
PubMed 
enables retinal dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cellular detoxification of aldehyde ISO
Inferred from Sequence Orthology
more info
 
involved_in daunorubicin metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in doxorubicin metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in farnesol catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in polyol metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in retinal metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in retinoid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in retinol metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
aldo-keto reductase family 1 member B10
Names
aldo-keto reductase family 1, member B10 (aldose reductase)
aldose reductase-related protein 1-like
NP_001013102.1
XP_038963219.1
XP_038963220.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013084.1NP_001013102.1  aldo-keto reductase family 1 member B10

    See identical proteins and their annotated locations for NP_001013102.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079133
    UniProtKB/TrEMBL
    Q6AY99
    Related
    ENSRNOP00000079554.1, ENSRNOT00000114062.1
    Conserved Domains (1) summary
    cd19107
    Location:10316
    AKR_AKR1B1-19; AKR1B family of aldo-keto reductase (AKR)

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051339.1 Reference mRatBN7.2 Primary Assembly

    Range
    63038459..63060336
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039107291.1XP_038963219.1  aldo-keto reductase family 1 member B10 isoform X1

    Related
    ENSRNOP00000065713.1, ENSRNOT00000074951.3
    Conserved Domains (1) summary
    cd19107
    Location:10316
    AKR_AKR1B1-19; AKR1B family of aldo-keto reductase (AKR)
  2. XM_039107292.1XP_038963220.1  aldo-keto reductase family 1 member B10 isoform X2

    Conserved Domains (1) summary
    cl00470
    Location:1172
    AKR_SF; Aldo-keto reductase (AKR) superfamily

RNA

  1. XR_001837481.2 RNA Sequence

Support Center