Akr1b10 aldo-keto reductase family 1 member B10 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Akr1b10provided by RGD
Full Name: aldo-keto reductase family 1 member B10provided by RGD
Primary source: RGD:1308277
See related: Ensembl:ENSRNOG00000009734 AllianceGenome:RGD:1308277
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables NADP binding activity; alcohol dehydrogenase (NADP+) activity; and retinal binding activity. Involved in polyol metabolic process; retinal metabolic process; and retinol metabolic process. Predicted to be located in extracellular region and lysosome. Predicted to be active in cytosol and mitochondrion. Orthologous to several human genes including AKR1B10 (aldo-keto reductase family 1 member B10). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Biased expression in Adrenal (RPKM 1546.2), Kidney (RPKM 276.7) and 3 other tissues See more
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Genomic context

Location:: 4q22

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (64005632..64027860)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (63038459..63060336)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (61813265..61830371)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results demonstrate that Akr7a3 mRNA and protein levels are consistently co-expressed along with Akr1b10, in both experimental rat liver carcinogenesis and some human hepatocellular carcinoma samples.
Title: Aldo-Keto Reductases as Early Biomarkers of Hepatocellular Carcinoma: A Comparison Between Animal Models and Human HCC.
Properties and tissue distribution of a novel carbonyl reductase (NADPH) encoding in a rat gene are reported.
Title: Properties and tissue distribution of a novel aldo-keto reductase encoding in a rat gene (Akr1b10).

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables aldose reductase (NADPH) activity	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: aldo-keto reductase family 1 member B10

Names: aldo-keto reductase family 1, member B10 (aldose reductase); aldose reductase-related protein 1-like

NP_001013102.1

EC 1.1.1.2

XP_038963219.1

EC 1.1.1.2

XP_038963220.1

EC 1.1.1.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013084.2 → NP_001013102.1 aldo-keto reductase family 1 member B10

See identical proteins and their annotated locations for NP_001013102.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/TrEMBL

A6IEL9, M0R8B8, Q6AY99

Conserved Domains (1) summary

cd19107
Location:10 → 316

AKR_AKR1B1-19; AKR1B family of aldo-keto reductase (AKR)
NM_001440130.1 → NP_001427059.1 aldo-keto reductase family 1 member B10

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/TrEMBL

A6IEL9, M0R8B8, Q6AY99

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

64005632..64027860

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039107291.2 → XP_038963219.1 aldo-keto reductase family 1 member B10 isoform X1

Related

ENSRNOP00000065713.1, ENSRNOT00000074951.4

Conserved Domains (1) summary

cd19107
Location:10 → 316

AKR_AKR1B1-19; AKR1B family of aldo-keto reductase (AKR)
XM_039107292.2 → XP_038963220.1 aldo-keto reductase family 1 member B10 isoform X2

UniProtKB/TrEMBL

A6IEM0

Conserved Domains (1) summary

cl00470
Location:1 → 172

AKR_SF; Aldo-keto reductase (AKR) superfamily