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Chchd3 coiled-coil-helix-coiled-coil-helix domain containing 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 296966, updated on 17-Aug-2024

Summary

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Official Symbol
Chchd3provided by RGD
Official Full Name
coiled-coil-helix-coiled-coil-helix domain containing 3provided by RGD
Primary source
RGD:1310325
See related
EnsemblRapid:ENSRNOG00000013211 AllianceGenome:RGD:1310325
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable molecular adaptor activity and phosphatase binding activity. Predicted to be involved in cristae formation and mitochondrial fusion. Predicted to be located in mitochondrial inner membrane. Predicted to be part of MICOS complex. Orthologous to human CHCHD3 (coiled-coil-helix-coiled-coil-helix domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 1526.2), Heart (RPKM 1301.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Chchd3 in Genome Data Viewer
Location:
4q22
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (62327574..62584085, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (61360352..61616850, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (60080536..60358592, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486671 Neighboring gene elongin B, pseduogene 10 Neighboring gene high-mobility group box 1, pseudogene 5 Neighboring gene exocyst complex component 4 Neighboring gene FAD-linked sulfhydryl oxidase ALR-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cloning and functional analysis of FLJ20420: a novel transcription factor for the BAG-1 promoter. Liu H, et al. PLoS One, 2012. PMID 22567091, Free PMC Article
  2. Mitofilin complexes: conserved organizers of mitochondrial membrane architecture. Zerbes RM, et al. Biol Chem, 2012 Nov. PMID 23109542
  3. Detailed analysis of the human mitochondrial contact site complex indicate a hierarchy of subunits. Ott C, et al. PLoS One, 2015. PMID 25781180, Free PMC Article
  4. ChChd3, an inner mitochondrial membrane protein, is essential for maintaining crista integrity and mitochondrial function. Darshi M, et al. J Biol Chem, 2011 Jan 28. PMID 21081504, Free PMC Article
  5. QIL1 is a novel mitochondrial protein required for MICOS complex stability and cristae morphology. Guarani V, et al. Elife, 2015 May 21. PMID 25997101, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphatase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in cristae formation ISO
Inferred from Sequence Orthology
more info
  
involved_in inner mitochondrial membrane organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in inner mitochondrial membrane organization ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial fusion ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of MICOS complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of MICOS complex ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
MICOS complex subunit MIC19
Names
coiled-coil-helix-coiled-coil-helix domain-containing protein 3, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106588.1 → NP_001100058.1  MICOS complex subunit MIC19

    See identical proteins and their annotated locations for NP_001100058.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473959
    UniProtKB/TrEMBL
    A6IEK5, D3ZUX5
    Related
    ENSRNOP00000018001.6, ENSRNOT00000018001.6
    Conserved Domains (1) summary
    pfam05300
    Location:15 → 175
    DUF737; Protein of unknown function (DUF737)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    62327574..62584085 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017592526.3 → XP_017448015.1  MICOS complex subunit MIC19 isoform X2

    UniProtKB/TrEMBL
    D3ZUX5

  2. XM_017592525.3 → XP_017448014.1  MICOS complex subunit MIC19 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AD55, D3ZUX5
    Related
    ENSRNOP00000092148.1, ENSRNOT00000107634.2

  3. XM_039107283.2 → XP_038963211.1  MICOS complex subunit MIC19 isoform X3

    Conserved Domains (1) summary
    pfam05300
    Location:18 → 68
    DUF737; Protein of unknown function (DUF737)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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