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Chchd3 coiled-coil-helix-coiled-coil-helix domain containing 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 296966, updated on 5-Jan-2022

Summary

Official Symbol
Chchd3provided by RGD
Official Full Name
coiled-coil-helix-coiled-coil-helix domain containing 3provided by RGD
Primary source
RGD:1310325
See related
Ensembl:ENSRNOG00000013211
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable molecular adaptor activity and phosphatase binding activity. Predicted to be involved in cristae formation and mitochondrial fusion. Predicted to be located in mitochondrial inner membrane. Predicted to be part of MICOS complex. Orthologous to human CHCHD3 (coiled-coil-helix-coiled-coil-helix domain containing 3). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in Muscle (RPKM 1526.2), Heart (RPKM 1301.7) and 9 other tissues See more
Orthologs
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Genomic context

See Chchd3 in Genome Data Viewer
Location:
4q22
Exon count:
10
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (61360352..61616850, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (60080536..60358592, complement)

Chromosome 4 - NC_051339.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108350688 Neighboring gene plexin A4 Neighboring gene similar to transcription elongation factor B (SIII), polypeptide 2 Neighboring gene similar to Hmgb1 protein Neighboring gene exocyst complex component 4 Neighboring gene FAD-linked sulfhydryl oxidase ALR-like

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables molecular_function ND
No biological Data available
more info
 
enables phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in cristae formation ISO
Inferred from Sequence Orthology
more info
 
involved_in inner mitochondrial membrane organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in inner mitochondrial membrane organization ISO
Inferred from Sequence Orthology
more info
 
involved_in mitochondrial fusion ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of MICOS complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of MICOS complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in cellular_component ND
No biological Data available
more info
 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
MICOS complex subunit MIC19
Names
coiled-coil-helix-coiled-coil-helix domain-containing protein 3, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106588.1NP_001100058.1  MICOS complex subunit MIC19

    See identical proteins and their annotated locations for NP_001100058.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473959
    UniProtKB/TrEMBL
    D3ZUX5
    Related
    ENSRNOP00000018001.5, ENSRNOT00000018001.5
    Conserved Domains (1) summary
    pfam05300
    Location:15175
    DUF737; Protein of unknown function (DUF737)

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051339.1 Reference mRatBN7.2 Primary Assembly

    Range
    61360352..61616850 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017592526.2XP_017448015.1  MICOS complex subunit MIC19 isoform X2

  2. XM_017592525.2XP_017448014.1  MICOS complex subunit MIC19 isoform X1

    Related
    ENSRNOP00000092148.1, ENSRNOT00000107634.1
  3. XM_039107281.1XP_038963209.1  MICOS complex subunit MIC19 isoform X3

    Conserved Domains (1) summary
    pfam05300
    Location:12103
    DUF737; Protein of unknown function (DUF737)
  4. XM_039107282.1XP_038963210.1  MICOS complex subunit MIC19 isoform X4

    Conserved Domains (1) summary
    pfam05300
    Location:1298
    DUF737; Protein of unknown function (DUF737)
  5. XM_039107283.1XP_038963211.1  MICOS complex subunit MIC19 isoform X5

    Conserved Domains (1) summary
    pfam05300
    Location:1868
    DUF737; Protein of unknown function (DUF737)
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