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Irf5 interferon regulatory factor 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 296953, updated on 8-Apr-2026
Official Symbol
Irf5provided by RGD
Official Full Name
interferon regulatory factor 5provided by RGD
Primary source
RGD:1310447
See related
Ensembl:ENSRNOG00000007437 AllianceGenome:RGD:1310447
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; identical protein binding activity; and protein serine/threonine kinase binding activity. Predicted to be involved in several processes, including cellular response to muramyl dipeptide; positive regulation of macromolecule biosynthetic process; and response to virus. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Biomarker of obstructive jaundice and ureteral obstruction. Human ortholog(s) of this gene implicated in herpes simplex; inflammatory bowel disease 14; multiple sclerosis; rheumatoid arthritis; and systemic lupus erythematosus. Orthologous to human IRF5 (interferon regulatory factor 5). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Spleen (RPKM 111.6), Thymus (RPKM 32.7) and 9 other tissues See more
Orthologs
all
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Try the new Transcripts and proteins table
See Irf5 in Genome Data Viewer
Location:
4q22
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (59092914..59104596)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (58127577..58140665)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (56804477..56816271)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene involucrin-like Neighboring gene kielin cysteine rich BMP regulator Neighboring gene transportin 3 Neighboring gene uncharacterized LOC134486568 Neighboring gene uncharacterized LOC102552812

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Depression Exacerbates Dextran Sulfate Sodium-Induced Colitis via IRF5-Mediated Macrophage Polarization. Liang C, et al. Dig Dis Sci, 2023 Apr. PMID 36088512
  2. Differences in IP‑10, TLR4 and IRF5/3 between SVR and non‑SVR HCV‑1 patients treated with PEG‑IFN and ribavirin. Zhang M, et al. Mol Med Rep, 2017 Apr. PMID 28259968
  3. An oligodeoxynucleotide with AAAG repeats significantly attenuates burn-induced systemic inflammatory responses via inhibiting interferon regulatory factor 5 pathway. Xiao Y, et al. Mol Med, 2017 Sep. PMID 28620671, Free PMC Article
  4. Interferon regulatory factor 5 is a potential target of autoimmune response triggered by Epstein-barr virus and Mycobacterium avium subsp. paratuberculosis in rheumatoid arthritis: investigating a mechanism of molecular mimicry. Bo M, et al. Clin Exp Rheumatol, 2018 May-Jun. PMID 29352853
  5. Sedum sarmentosum Bunge extract alleviates inflammation and kidney injury via inhibition of M1-macrophage polarization. Lu H, et al. Phytomedicine, 2019 Sep. PMID 31177020

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mechanism of IRF5-regulated CXCL13/CXCR5 Signaling Axis in CCI-induced Neuropathic Pain in Rats.
    Title: Mechanism of IRF5-regulated CXCL13/CXCR5 Signaling Axis in CCI-induced Neuropathic Pain in Rats.
  2. Depression Exacerbates Dextran Sulfate Sodium-Induced Colitis via IRF5-Mediated Macrophage Polarization.
    Title: Depression Exacerbates Dextran Sulfate Sodium-Induced Colitis via IRF5-Mediated Macrophage Polarization.
  3. BoDV-1 infection induces neuroinflammation by activating the TLR4/MyD88/IRF5 signaling pathway, leading to learning and memory impairment in rats.
    Title: BoDV-1 infection induces neuroinflammation by activating the TLR4/MyD88/IRF5 signaling pathway, leading to learning and memory impairment in rats.
  4. Bone marrow mesenchymal stem cell-derived exosomal microRNA-125a promotes M2 macrophage polarization in spinal cord injury by downregulating IRF5.
    Title: Bone marrow mesenchymal stem cell-derived exosomal microRNA-125a promotes M2 macrophage polarization in spinal cord injury by downregulating IRF5.
  5. MicroRNA-22-3p alleviates spinal cord ischemia/reperfusion injury by modulating M2 macrophage polarization via IRF5.
    Title: MicroRNA-22-3p alleviates spinal cord ischemia/reperfusion injury by modulating M2 macrophage polarization via IRF5.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in immune system process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
interferon regulatory factor 5

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106586.2 → NP_001100056.1  interferon regulatory factor 5 isoform 2

    See identical proteins and their annotated locations for NP_001100056.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A0A8I5YBA0, A6IEE2
    Related
    ENSRNOP00000069195.3, ENSRNOT00000085483.3
    Conserved Domains (2) summary
    pfam00605
    Location:16 → 121
    IRF; Interferon regulatory factor transcription factor
    pfam10401
    Location:247 → 430
    IRF-3; Interferon-regulatory factor 3

  2. NM_001439921.1 → NP_001426850.1  interferon regulatory factor 5 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A0A8I5YBA0

  3. NM_001439922.1 → NP_001426851.1  interferon regulatory factor 5 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A0A8I5YBA0

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    59092914..59104596
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008762765.4 → XP_008760987.1  interferon regulatory factor 5 isoform X4

    See identical proteins and their annotated locations for XP_008760987.1

    UniProtKB/TrEMBL
    A0A8I5YBA0
    Conserved Domains (2) summary
    pfam00605
    Location:16 → 121
    IRF; Interferon regulatory factor transcription factor
    pfam10401
    Location:251 → 434
    IRF-3; Interferon-regulatory factor 3

  2. XM_063285738.1 → XP_063141808.1  interferon regulatory factor 5 isoform X3

    UniProtKB/TrEMBL
    A0A8I5YBA0
    Related
    ENSRNOP00000109028.1, ENSRNOT00000135232.1

  3. XM_039107277.2 → XP_038963205.1  interferon regulatory factor 5 isoform X1

    UniProtKB/TrEMBL
    A0A8I5YBA0
    Conserved Domains (2) summary
    pfam00605
    Location:43 → 148
    IRF; Interferon regulatory factor transcription factor
    pfam10401
    Location:278 → 461
    IRF-3; Interferon-regulatory factor 3

  4. XM_006236184.5 → XP_006236246.1  interferon regulatory factor 5 isoform X4

    Related
    ENSRNOP00000100832.1, ENSRNOT00000168534.1
    Conserved Domains (2) summary
    pfam00605
    Location:16 → 121
    IRF; Interferon regulatory factor transcription factor
    pfam10401
    Location:251 → 434
    IRF-3; Interferon-regulatory factor 3

  5. XM_006236185.5 → XP_006236247.1  interferon regulatory factor 5 isoform X4

    See identical proteins and their annotated locations for XP_006236247.1

    UniProtKB/TrEMBL
    A0A8I5YBA0
    Conserved Domains (2) summary
    pfam00605
    Location:16 → 121
    IRF; Interferon regulatory factor transcription factor
    pfam10401
    Location:251 → 434
    IRF-3; Interferon-regulatory factor 3

  6. XM_039107278.2 → XP_038963206.1  interferon regulatory factor 5 isoform X2

    UniProtKB/TrEMBL
    A0A8I5YBA0, D3ZPU1
    Related
    ENSRNOP00000010001.6, ENSRNOT00000010001.8
    Conserved Domains (2) summary
    pfam00605
    Location:25 → 130
    IRF; Interferon regulatory factor transcription factor
    pfam10401
    Location:260 → 443
    IRF-3; Interferon-regulatory factor 3
Nucleotide Protein Strain
Heading Accession and Version

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