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Aass aminoadipate-semialdehyde synthase [ Rattus norvegicus (Norway rat) ]

Gene ID: 296925, updated on 21-Jul-2018

Summary

Official Symbol
Aassprovided by RGD
Official Full Name
aminoadipate-semialdehyde synthaseprovided by RGD
Primary source
RGD:1310811
See related
Ensembl:ENSRNOG00000039494
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Annotation information
Annotation category: partial on reference assembly
Expression
Biased expression in Kidney (RPKM 1136.0) and Liver (RPKM 851.7) See more
Orthologs

Genomic context

See Aass in Genome Data Viewer
Location:
4q22
Exon count:
25
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (50152005..50208935, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 4 NC_005103.3 (49938569..49993864, complement)

Chromosome 4 - NC_005103.4Genomic Context describing neighboring genes Neighboring gene hypothetical LOC100359863 Neighboring gene protein tyrosine phosphatase, receptor type Z1 Neighboring gene similar to 40S ribosomal protein S3 Neighboring gene 60S ribosomal protein L27 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from BioSystems

General gene information

Homology

  • Homologs of the Aass gene: The Aass gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
  • Orthologs from Annotation Pipeline: 244 organisms have orthologs with human gene Aass

Gene Ontology Provided by RGD

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity IEA
Inferred from Electronic Annotation
more info
 
saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity ISO
Inferred from Sequence Orthology
more info
 
saccharopine dehydrogenase (NADP+, L-lysine-forming) activity IEA
Inferred from Electronic Annotation
more info
 
saccharopine dehydrogenase (NADP+, L-lysine-forming) activity ISO
Inferred from Sequence Orthology
more info
 
saccharopine dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
L-lysine catabolic process IEA
Inferred from Electronic Annotation
more info
 
L-lysine catabolic process ISO
Inferred from Sequence Orthology
more info
 
L-lysine catabolic process to acetyl-CoA via saccharopine IEA
Inferred from Electronic Annotation
more info
 
biological_process ND
No biological Data available
more info
 
lysine biosynthetic process via aminoadipic acid IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
alpha-aminoadipic semialdehyde synthase, mitochondrial
Names
LKR/SDH
NP_001094433.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100963.1NP_001094433.1  alpha-aminoadipic semialdehyde synthase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001094433.1

    Status: PROVISIONAL

    Source sequence(s)
    BC128771
    UniProtKB/Swiss-Prot
    A2VCW9
    Related
    ENSRNOP00000057271.4, ENSRNOT00000060530.4
    Conserved Domains (4) summary
    PLN02819
    Location:25916
    PLN02819; lysine-ketoglutarate reductase/saccharopine dehydrogenase
    cd12189
    Location:25466
    LKR_SDH_like; bifunctional lysine ketoglutarate reductase /saccharopine dehydrogenase enzyme
    pfam03435
    Location:483598
    Sacchrp_dh_NADP; Saccharopine dehydrogenase NADP binding domain
    pfam16653
    Location:602915
    Sacchrp_dh_C; Saccharopine dehydrogenase C-terminal domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005103.4 Reference Rnor_6.0 Primary Assembly

    Range
    50152005..50208935 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000072.1 Alternate Rn_Celera

    Range
    46798734..46861408 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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