Gabrd gamma-aminobutyric acid type A receptor subunit delta [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gabrdprovided by RGD
Official Full Name: gamma-aminobutyric acid type A receptor subunit deltaprovided by RGD
Primary source: RGD:61901
See related: Ensembl:ENSRNOG00000016385 AllianceGenome:RGD:61901
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: GABAA-RD
Summary: Enables GABA-A receptor activity. Involved in chemical synaptic transmission. Is active in GABA-ergic synapse and glutamatergic synapse. Is integral component of postsynaptic membrane. Human ortholog(s) of this gene implicated in idiopathic generalized epilepsy 10. Orthologous to human GABRD (gamma-aminobutyric acid type A receptor subunit delta). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 236.9) See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
108	current	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (165958508..165970407, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (172797478..172809374, complement)

Chromosome 5 - NC_051340.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Dual Role of the GABAA Receptor in Peripheral Inflammation and Neuroinflammation: A Study in Hyperammonemic Rats.
Title: The Dual Role of the GABA(A) Receptor in Peripheral Inflammation and Neuroinflammation: A Study in Hyperammonemic Rats.
Ameliorative effect of curcumin on altered expression of CACNA1A and GABRD in the pathogenesis of FeCl3-induced epilepsy.
Title: Ameliorative effect of curcumin on altered expression of CACNA1A and GABRD in the pathogenesis of FeCl(3)-induced epilepsy.
the subunit arrangement of alpha4beta2delta GABAA receptors is not strongly predefined but is mostly satisfying the 2:2:1 subunit stoichiometry for alpha4, beta2, and delta subunits and that several subunit arrangements result in receptors with similar functional properties tuned to physiological conditions.
Title: Toward Understanding Functional Properties and Subunit Arrangement of α4β2δ γ-Aminobutyric Acid, Type A (GABAA) Receptors.
Data suggest that GABA(A) receptor subunits (alpha-1 and beta-3) are able to form homologous receptors with either delta (extrasynaptic) or gamma-2 subunits (synaptic); allosteric modulation appears similar in the presence of agonist etomidate.
Title: Etomidate produces similar allosteric modulation in α1β3δ and α1β3γ2L GABA(A) receptors.
pregnancy may provoke perturbations in gamma oscillatory activity through direct effects on the GABAergic system, and underscore the importance of delta-GABA(A)Rs homeostatic plasticity in maintaining constant network output despite large hormonal changes.
Title: Altered gamma oscillations during pregnancy through loss of δ subunit-containing GABA(A) receptors on parvalbumin interneurons.
Expression of alpha4betadelta GABA receptors increases on the dendrites of CA1 pyramidal cells at the onset of puberty in the hippocampus, part of the limbic circuitry which governs emotion.
Title: The influence of stress at puberty on mood and learning: role of the α4βδ GABAA receptor.
Adolescent female rats exhibiting activity-based anorexia express elevated levels of GABAA receptor delta subunit at the plasma membrane of hippocampal CA1 spines
Title: Adolescent female rats exhibiting activity-based anorexia express elevated levels of GABA(A) receptor α4 and δ subunits at the plasma membrane of hippocampal CA1 spines.
CCI caused a 194% and 127% increase of delta protein in the hippocampi of the controlled cortical impact group compared to control and post-traumatic epilepsy groups, respectively.
Title: Alterations of GABA(A) and glutamate receptor subunits and heat shock protein in rat hippocampus following traumatic brain injury and in posttraumatic epilepsy.
Data show that Cbln1 and Cbln2, but not Cbln4, specifically bind to neurexin 1alpha and -beta and induce synaptogenesis in cerebellar, hippocampal and cortical neurons in vitro.
Title: Non-neuronal, slow GABA signalling in the ventrobasal thalamus targets δ-subunit-containing GABA(A) receptors.
demonstrated the expression of delta-subunit containing GABA(A) receptors capable of mediating a tonic inhibitory Cl(-) current
Title: Extrasynaptic GABA(A) receptors and tonic inhibition in rat auditory thalamus.

Submit: New GeneRIF Correction See all GeneRIFs (22)

General gene information

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Markers

PMC23157P1 (e-PCR)
- UniSTS:272193

BF390464 (e-PCR)
- UniSTS:249477

RH139554 (e-PCR)
- UniSTS:221639

NoName (e-PCR)
- UniSTS:491235

RH143455 (e-PCR)
- UniSTS:232702

Homology

Orthologs from Annotation Pipeline: 512 organisms have orthologs with human gene Gabrd
Orthologs

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GABA-A receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables GABA-A receptor activity	IEA Inferred from Electronic Annotation more info
contributes_to chloride channel activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables chloride channel activity	IEA Inferred from Electronic Annotation more info
enables extracellular ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables neurotransmitter receptor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in chloride transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in chloride transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in nervous system process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in regulation of membrane potential	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in regulation of postsynaptic membrane potential	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Component	Evidence Code	Pubs
part_of GABA-A receptor complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
located_in axon	ISO Inferred from Sequence Orthology more info
part_of chloride channel complex	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

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Preferred Names: gamma-aminobutyric acid receptor subunit delta

Names: GABA(A) receptor subunit delta; GABA-A receptor delta-subunit; GABAA receptor delta subunit; gamma-aminobutyric acid (GABA) A receptor, delta; gamma-aminobutyric acid (GABA-A) receptor, subunit delta; gamma-aminobutyric acid A receptor, delta; gamma-aminobutyric acid type A receptor delta subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017289.2 → NP_058985.1 gamma-aminobutyric acid receptor subunit delta precursor

See identical proteins and their annotated locations for NP_058985.1

Status: PROVISIONAL

Source sequence(s)

JACYVU010000162

UniProtKB/Swiss-Prot

P18506

Related

ENSRNOP00000022246.2, ENSRNOT00000022246.5

Conserved Domains (2) summary

cl28912
Location:63 → 246

LGIC_ECD; extracellular domain (ECD) of Cys-loop neurotransmitter-gated ion channels (also known as ligand-gated ion channel (LGIC))

cl38911
Location:249 → 337

LGIC_TM; transmembrane domain of Cys-loop neurotransmitter-gated ion channels