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Psma6 proteasome 20S subunit alpha 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29673, updated on 2-May-2024

Summary

Official Symbol
Psma6provided by RGD
Official Full Name
proteasome 20S subunit alpha 6provided by RGD
Primary source
RGD:61849
See related
Ensembl:ENSRNOG00000007114 AllianceGenome:RGD:61849
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable NF-kappaB binding activity and RNA binding activity. Predicted to be involved in positive regulation of NF-kappaB transcription factor activity and proteasomal protein catabolic process. Located in sarcomere. Human ortholog(s) of this gene implicated in myocardial infarction. Orthologous to human PSMA6 (proteasome 20S subunit alpha 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 1339.4), Muscle (RPKM 864.3) and 9 other tissues See more
Orthologs
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Genomic context

See Psma6 in Genome Data Viewer
Location:
6q23
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (78500676..78531693)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (72765534..72796554)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (76174460..76205429)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479210 Neighboring gene family with sequence similarity 177, member A1 Neighboring gene protein phosphatase 2, regulatory subunit B'', gamma Neighboring gene protein only RNase P catalytic subunit Neighboring gene NFKB inhibitor alpha Neighboring gene aldolase 1 A retrogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Clone Names

  • MGC72876

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables NF-kappaB binding IEA
Inferred from Electronic Annotation
more info
 
enables NF-kappaB binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in P-body IEA
Inferred from Electronic Annotation
more info
 
located_in P-body ISO
Inferred from Sequence Orthology
more info
 
located_in P-body ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in myofibril IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear matrix IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear matrix ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear matrix ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of proteasome complex ISO
Inferred from Sequence Orthology
more info
 
part_of proteasome core complex ISO
Inferred from Sequence Orthology
more info
 
part_of proteasome core complex ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of proteasome core complex, alpha-subunit complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of proteasome core complex, alpha-subunit complex IEA
Inferred from Electronic Annotation
more info
 
part_of proteasome core complex, alpha-subunit complex ISO
Inferred from Sequence Orthology
more info
 
part_of proteasome core complex, alpha-subunit complex ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in ribosome IEA
Inferred from Electronic Annotation
more info
 
located_in ribosome ISO
Inferred from Sequence Orthology
more info
 
located_in ribosome ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in sarcomere IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
proteasome subunit alpha type-6
Names
macropain iota chain
multicatalytic endopeptidase complex iota chain
proteasome (prosome, macropain) subunit, alpha type 6
proteasome alpha 6 subunit
proteasome iota chain
proteasome subunit alpha 6
NP_058979.1
XP_006240160.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017283.3NP_058979.1  proteasome subunit alpha type-6

    See identical proteins and their annotated locations for NP_058979.1

    Status: PROVISIONAL

    Source sequence(s)
    BC062232
    UniProtKB/Swiss-Prot
    P60901
    UniProtKB/TrEMBL
    A0A8I6GE69, A6HBM1
    Related
    ENSRNOP00000009666.3, ENSRNOT00000009666.7
    Conserved Domains (1) summary
    cd03754
    Location:8220
    proteasome_alpha_type_6; The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    78500676..78531693
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006240098.5XP_006240160.1  proteasome subunit alpha type-6 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K0D7, A0A8I6GE69
    Related
    ENSRNOP00000071403.1
    Conserved Domains (1) summary
    cd03754
    Location:8201
    proteasome_alpha_type_6; proteasome_alpha_type_6. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on ...