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Gsn gelsolin [ Rattus norvegicus (Norway rat) ]

Gene ID: 296654, updated on 10-Oct-2019

Summary

Official Symbol
Gsnprovided by RGD
Official Full Name
gelsolinprovided by RGD
Primary source
RGD:1303089
See related
Ensembl:ENSRNOG00000018991
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
plays a role in phosphoinositide mediated disassembly of actin filaments in Sertoli cell adhesion complexes; may regulate sperm release and turnover of the blood-testis barrier [RGD, Feb 2006]
Expression
Biased expression in Lung (RPKM 4957.5), Heart (RPKM 3919.5) and 5 other tissues See more
Orthologs

Genomic context

See Gsn in Genome Data Viewer
Location:
3p11
Exon count:
20
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (14456106..14508922)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 3 NC_005102.3 (19773655..19826463)

Chromosome 3 - NC_005102.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102548763 Neighboring gene uncharacterized LOC102554040 Neighboring gene 40S ribosomal protein S29 pseudogene Neighboring gene stomatin Neighboring gene glycoprotein, alpha-galactosyltransferase 1-like 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC95032

Gene Ontology Provided by RGD

Function Evidence Code Pubs
actin binding IDA
Inferred from Direct Assay
more info
PubMed 
actin binding ISO
Inferred from Sequence Orthology
more info
PubMed 
actin filament binding IEA
Inferred from Electronic Annotation
more info
 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
calcium ion binding ISO
Inferred from Sequence Orthology
more info
PubMed 
myosin II binding IEA
Inferred from Electronic Annotation
more info
 
myosin II binding ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
actin filament capping ISO
Inferred from Sequence Orthology
more info
PubMed 
actin filament polymerization ISO
Inferred from Sequence Orthology
more info
PubMed 
actin filament polymerization ISS
Inferred from Sequence or Structural Similarity
more info
 
actin filament reorganization IEA
Inferred from Electronic Annotation
more info
 
actin filament reorganization ISO
Inferred from Sequence Orthology
more info
PubMed 
actin filament severing IMP
Inferred from Mutant Phenotype
more info
PubMed 
actin filament severing ISO
Inferred from Sequence Orthology
more info
PubMed 
actin filament severing ISS
Inferred from Sequence or Structural Similarity
more info
 
actin nucleation IEA
Inferred from Electronic Annotation
more info
 
actin polymerization or depolymerization IDA
Inferred from Direct Assay
more info
PubMed 
aging IEP
Inferred from Expression Pattern
more info
PubMed 
amyloid fibril formation IEA
Inferred from Electronic Annotation
more info
 
amyloid fibril formation ISO
Inferred from Sequence Orthology
more info
PubMed 
apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
barbed-end actin filament capping IEA
Inferred from Electronic Annotation
more info
 
cellular response to cadmium ion IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to interferon-gamma IEA
Inferred from Electronic Annotation
more info
 
cellular response to interferon-gamma ISO
Inferred from Sequence Orthology
more info
PubMed 
cilium assembly ISO
Inferred from Sequence Orthology
more info
PubMed 
cilium assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT extracellular matrix disassembly ISO
Inferred from Sequence Orthology
more info
PubMed 
hepatocyte apoptotic process IEA
Inferred from Electronic Annotation
more info
 
hepatocyte apoptotic process ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of viral entry into host cell IEA
Inferred from Electronic Annotation
more info
 
negative regulation of viral entry into host cell ISO
Inferred from Sequence Orthology
more info
PubMed 
oligodendrocyte development IEP
Inferred from Expression Pattern
more info
PubMed 
phagocytosis, engulfment IEA
Inferred from Electronic Annotation
more info
 
phagocytosis, engulfment ISO
Inferred from Sequence Orthology
more info
PubMed 
phosphatidylinositol-mediated signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of actin nucleation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of actin nucleation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of keratinocyte apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of keratinocyte apoptotic process ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of protein processing in phagocytic vesicle IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein processing in phagocytic vesicle ISO
Inferred from Sequence Orthology
more info
PubMed 
protein destabilization IEA
Inferred from Electronic Annotation
more info
 
protein destabilization ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of establishment of T cell polarity IEA
Inferred from Electronic Annotation
more info
 
regulation of establishment of T cell polarity ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of plasma membrane raft polarization IEA
Inferred from Electronic Annotation
more info
 
regulation of plasma membrane raft polarization ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of podosome assembly IEA
Inferred from Electronic Annotation
more info
 
regulation of podosome assembly ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of receptor clustering IEA
Inferred from Electronic Annotation
more info
 
regulation of receptor clustering ISO
Inferred from Sequence Orthology
more info
PubMed 
renal protein absorption IEA
Inferred from Electronic Annotation
more info
 
renal protein absorption ISO
Inferred from Sequence Orthology
more info
PubMed 
response to ethanol IEP
Inferred from Expression Pattern
more info
PubMed 
response to folic acid IEP
Inferred from Expression Pattern
more info
PubMed 
sequestering of actin monomers IEA
Inferred from Electronic Annotation
more info
 
sequestering of actin monomers ISO
Inferred from Sequence Orthology
more info
PubMed 
striated muscle atrophy IEA
Inferred from Electronic Annotation
more info
 
striated muscle atrophy ISO
Inferred from Sequence Orthology
more info
PubMed 
tissue regeneration IEP
Inferred from Expression Pattern
more info
PubMed 
vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
PubMed 
wound healing IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
actin cap IEA
Inferred from Electronic Annotation
more info
 
actin cap ISO
Inferred from Sequence Orthology
more info
PubMed 
actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
cell IEA
Inferred from Electronic Annotation
more info
 
cortical actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
PubMed 
colocalizes_with cortical actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
PubMed 
cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular region ISO
Inferred from Sequence Orthology
more info
PubMed 
extracellular region ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
PubMed 
focal adhesion IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with focal adhesion ISO
Inferred from Sequence Orthology
more info
PubMed 
lamellipodium IEA
Inferred from Electronic Annotation
more info
 
lamellipodium ISO
Inferred from Sequence Orthology
more info
PubMed 
myelin sheath IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
phagocytic vesicle IEA
Inferred from Electronic Annotation
more info
 
phagocytic vesicle ISO
Inferred from Sequence Orthology
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
podosome IEA
Inferred from Electronic Annotation
more info
 
podosome ISO
Inferred from Sequence Orthology
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
ruffle IDA
Inferred from Direct Assay
more info
PubMed 
sarcoplasm IEA
Inferred from Electronic Annotation
more info
 
sarcoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
gelsolin
Names
ADF
actin-depolymerizing factor
brevin

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004080.1NP_001004080.1  gelsolin precursor

    See identical proteins and their annotated locations for NP_001004080.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079472
    UniProtKB/Swiss-Prot
    Q68FP1
    Related
    ENSRNOP00000025857.5, ENSRNOT00000025857.5
    Conserved Domains (6) summary
    cd11288
    Location:559647
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:184273
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:57169
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:664762
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:296393
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:437537
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005102.4 Reference Rnor_6.0 Primary Assembly

    Range
    14456106..14508922
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017591662.1XP_017447151.1  gelsolin isoform X1

    Conserved Domains (6) summary
    cd11288
    Location:521609
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:146235
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:19131
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:626724
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:258355
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:399499
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  2. XM_006234040.2XP_006234102.1  gelsolin isoform X2

    UniProtKB/Swiss-Prot
    Q68FP1
    Related
    ENSRNOP00000075631.1, ENSRNOT00000078939.1
    Conserved Domains (6) summary
    cd11288
    Location:510598
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:135224
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:8120
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:615713
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:247344
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:388488
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

Alternate Rn_Celera

Genomic

  1. AC_000071.1 Alternate Rn_Celera

    Range
    13325045..13351501
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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