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Mapkap1 mitogen-activated protein kinase associated protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 296648, updated on 9-Oct-2018

Summary

Official Symbol
Mapkap1provided by RGD
Official Full Name
mitogen-activated protein kinase associated protein 1provided by RGD
Primary source
RGD:1305363
See related
Ensembl:ENSRNOG00000017583
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Expression
Biased expression in Kidney (RPKM 156.7), Thymus (RPKM 153.6) and 9 other tissues See more
Orthologs

Genomic context

See Mapkap1 in Genome Data Viewer
Location:
3p11
Exon count:
14
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (13484952..13701772)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 3 NC_005102.3 (18808956..19022969)

Chromosome 3 - NC_005102.4Genomic Context describing neighboring genes Neighboring gene PBX homeobox 3 Neighboring gene uncharacterized LOC103691768 Neighboring gene uncharacterized LOC108350353 Neighboring gene 40S ribosomal protein S7-like Neighboring gene GTPase activating protein and VPS9 domains 1 Neighboring gene heat shock protein family A member 5

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
Ras GTPase binding ISO
Inferred from Sequence Orthology
more info
 
molecular_function ND
No biological Data available
more info
 
phosphatidic acid binding ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol-3,4,5-trisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol-3,4-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol-3,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol-4,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol-4,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein kinase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
TORC2 signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
biological_process ND
No biological Data available
more info
 
establishment or maintenance of actin cytoskeleton polarity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of cellular response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
TORC2 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
TORC2 complex ISO
Inferred from Sequence Orthology
more info
 
cellular_component ND
No biological Data available
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
target of rapamycin complex 2 subunit MAPKAP1
Names
SAPK-interacting protein 1
TORC2 subunit MAPKAP1
mitogen-activated protein kinase 2-associated protein 1
stress-activated map kinase-interacting protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001011964.1NP_001011964.1  target of rapamycin complex 2 subunit MAPKAP1

    See identical proteins and their annotated locations for NP_001011964.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079073
    UniProtKB/Swiss-Prot
    Q6AYF1
    Related
    ENSRNOP00000023889.5, ENSRNOT00000023889.6
    Conserved Domains (3) summary
    cd13331
    Location:383490
    PH_Avo1; Avo1 Pleckstrin homology (PH) domain
    pfam05422
    Location:18129
    SIN1; Stress-activated map kinase interacting protein 1 (SIN1)
    pfam16978
    Location:139266
    CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005102.4 Reference Rnor_6.0 Primary Assembly

    Range
    13484952..13701772
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006233949.2XP_006234011.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X1

    See identical proteins and their annotated locations for XP_006234011.1

    UniProtKB/Swiss-Prot
    Q6AYF1
    Conserved Domains (3) summary
    cd13331
    Location:383490
    PH_Avo1; Avo1 Pleckstrin homology (PH) domain
    pfam05422
    Location:18129
    SIN1; Stress-activated map kinase interacting protein 1 (SIN1)
    pfam16978
    Location:139266
    CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
  2. XM_008761721.1XP_008759943.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X3

    See identical proteins and their annotated locations for XP_008759943.1

    Conserved Domains (2) summary
    cd13331
    Location:191298
    PH_Avo1; Avo1 Pleckstrin homology (PH) domain
    pfam16978
    Location:174
    CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
  3. XM_008761722.1XP_008759944.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X3

    See identical proteins and their annotated locations for XP_008759944.1

    Conserved Domains (2) summary
    cd13331
    Location:191298
    PH_Avo1; Avo1 Pleckstrin homology (PH) domain
    pfam16978
    Location:174
    CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
  4. XM_017591652.1XP_017447141.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X1

    UniProtKB/Swiss-Prot
    Q6AYF1
    Conserved Domains (3) summary
    cd13331
    Location:383490
    PH_Avo1; Avo1 Pleckstrin homology (PH) domain
    pfam05422
    Location:18129
    SIN1; Stress-activated map kinase interacting protein 1 (SIN1)
    pfam16978
    Location:139266
    CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
  5. XM_006233950.2XP_006234012.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X1

    See identical proteins and their annotated locations for XP_006234012.1

    UniProtKB/Swiss-Prot
    Q6AYF1
    Conserved Domains (3) summary
    cd13331
    Location:383490
    PH_Avo1; Avo1 Pleckstrin homology (PH) domain
    pfam05422
    Location:18129
    SIN1; Stress-activated map kinase interacting protein 1 (SIN1)
    pfam16978
    Location:139266
    CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
  6. XM_017591654.1XP_017447143.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X3

  7. XM_017591656.1XP_017447145.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X3

  8. XM_017591651.1XP_017447140.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X1

    UniProtKB/Swiss-Prot
    Q6AYF1
    Conserved Domains (3) summary
    cd13331
    Location:383490
    PH_Avo1; Avo1 Pleckstrin homology (PH) domain
    pfam05422
    Location:18129
    SIN1; Stress-activated map kinase interacting protein 1 (SIN1)
    pfam16978
    Location:139266
    CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
  9. XM_008761720.1XP_008759942.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X2

    Conserved Domains (3) summary
    cd13331
    Location:347454
    PH_Avo1; Avo1 Pleckstrin homology (PH) domain
    pfam05422
    Location:18129
    SIN1; Stress-activated map kinase interacting protein 1 (SIN1)
    pfam16978
    Location:139266
    CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
  10. XM_017591653.1XP_017447142.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X3

  11. XM_017591655.1XP_017447144.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X3

  12. XM_017591657.1XP_017447146.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X3

Alternate Rn_Celera

Genomic

  1. AC_000071.1 Alternate Rn_Celera

    Range
    12437407..12639132
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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