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Cacfd1 calcium channel flower domain containing 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 296599, updated on 30-Jul-2025
Official Symbol
Cacfd1provided by RGD
Official Full Name
calcium channel flower domain containing 1provided by RGD
Primary source
RGD:1311501
See related
Ensembl:ENSRNOG00000005840 AllianceGenome:RGD:1311501
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Fwe; Fwe2; RGD1311501
Summary
Predicted to be involved in vesicle-mediated transport. Predicted to be located in Golgi apparatus; plasma membrane; and synaptic vesicle. Orthologous to human CACFD1 (calcium channel flower domain containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Kidney (RPKM 103.8), Muscle (RPKM 99.9) and 9 other tissues See more
Orthologs
human mouse all
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See Cacfd1 in Genome Data Viewer
Location:
3p12
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (30733958..30750237)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (10335881..10352437)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (5555807..5571205)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene serine/threonine kinase-like domain containing 1 Neighboring gene REX4 homolog, 3'-5' exonuclease Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif, 13 Neighboring gene uncharacterized LOC102548484 Neighboring gene solute carrier family 2 member 6 Neighboring gene myomaker, myoblast fusion factor Neighboring gene ADAMTS-like 2

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. A Ca2+ channel differentially regulates Clathrin-mediated and activity-dependent bulk endocytosis. Yao CK, et al. PLoS Biol, 2017 Apr. PMID 28414717, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The role of Fwe protein isoform 2 in endocytosis in hippocampal neurons
    Title: A Ca2+ channel differentially regulates Clathrin-mediated and activity-dependent bulk endocytosis.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  
located_in synaptic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in vesicle IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
calcium channel flower homolog
Names
calcium channel flower domain-containing protein 1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106561.1 → NP_001100031.1  calcium channel flower homolog

    See identical proteins and their annotated locations for NP_001100031.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474001
    UniProtKB/Swiss-Prot
    D4A9I3
    UniProtKB/TrEMBL
    A6JTJ9
    Related
    ENSRNOP00000109944.1, ENSRNOT00000155871.1
    Conserved Domains (1) summary
    smart01077
    Location:34 → 142
    Cg6151-P; Uncharacterized conserved protein CG6151-P

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    30733958..30750237
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006233756.5 → XP_006233818.1  calcium channel flower homolog isoform X1

    See identical proteins and their annotated locations for XP_006233818.1

    UniProtKB/Swiss-Prot
    D4A9I3
    UniProtKB/TrEMBL
    A6JTJ9
    Conserved Domains (1) summary
    smart01077
    Location:34 → 142
    Cg6151-P; Uncharacterized conserved protein CG6151-P

  2. XM_008761633.4 → XP_008759855.1  calcium channel flower homolog isoform X3

    Conserved Domains (1) summary
    cl10918
    Location:34 → 100
    Cg6151-P; Uncharacterized conserved protein CG6151-P

  3. XM_039104726.2 → XP_038960654.1  calcium channel flower homolog isoform X2

    UniProtKB/TrEMBL
    A0A8L2Q414
    Conserved Domains (1) summary
    cl10918
    Location:34 → 106
    Cg6151-P; Uncharacterized conserved protein CG6151-P
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D4A9I3.1 GenPept UniProtKB/Swiss-Prot:D4A9I3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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